Laboratory assessment of sudden sensorineural hearing loss: A case‐control study

Fasano, Tommaso; Pertinhez, Thelma A.; Tribi, Lorenzo; Lasagni, Donatella; Pilia, Annalisa; Vecchia, Luigi La; Baricchi, Roberto; Bianchin, Giovanni

doi:10.1002/lary.26514

Cited by 59 publications

(65 citation statements)

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“…Cardiovascular and metabolic diseases such as hypertension, diabetes mellitus (DM) and hyperlipidemia, will reduce the elasticity of blood vessels and induce the formation of atherosclerosis, thus causing microangiopathy. Several studies have confirmed these findings, suggesting that these comorbidities are clinically associated with ISSNHL 10,11 .…”

mentioning

confidence: 70%

“…In addition, another study reported that in comparison with healthy controls, higher levels of blood glucose, glycated hemoglobin (HbA1C), lipoprotein (a), and factor VIII were found among ISSNHL patients. The moderate-severe ISSNHL (PTA > 40 dB HL) patients showed higher significant values of blood glucose, glycated hemoglobin (HbA1C), uric acid, factor VIII, and homocysteine than mild ISSNHL (PTA ≤ 40 dB HL) patients 10 . All these laboratory parameters reflect the patients' metabolic and thrombophilic states and are considered to be the possible factors involved in a vascular etiology of ISSNHL.…”

Section: Discussionmentioning

confidence: 91%

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Analysis of Clinical and Laboratory Findings of Idiopathic Sudden Sensorineural Hearing Loss

Xie

Dai

Liu

et al. 2020

Sci Rep

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Idiopathic sudden sensorineural hearing loss (ISSNHL) is an emergency disease requiring immediate diagnosis and treatment. the incidence of iSSnHL in the Western countries' population was estimated to 5-20 per 100,000 inhabitants. The etiology of ISSNHL remains unknown. Its pathogenesis is most often suggested to be due to a disturbed microcirculation and infection. previous studies have reported that comorbidities, including hypertension, diabetes mellitus (DM), and hyperfibrinogenemia are risk factors of ISSNHL. This study aimed at investigating the clinical characteristics, laboratory parameters and comorbidities of patients with iSSnHL. our study suggests that the annual incidence of iSSnHL in China mainland is 19 per 100 000. The clinical characteristics and prevalence of comorbidities of ISSNHL patients are different according to age distribution and hearing results. Moreover, the patients with vertigo, hypertension, DM and high TG suffered more often from severe hearing loss compared with the counterparts. this indicates that the cardiovascular and metabolic diseases (hypertension and hyperlipidemia) appeared to be closely associated with the occurrence and severity of iSSnHL.

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mentioning

confidence: 70%

Section: Discussionmentioning

confidence: 91%

Analysis of Clinical and Laboratory Findings of Idiopathic Sudden Sensorineural Hearing Loss

Xie

Dai

Liu

et al. 2020

Sci Rep

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“…[1][2][3] In SSNHL development, vascular, infectious, autoimmune, traumatic, metabolic, hematologic, and neurological mechanisms have been suggested and is still being discussed. [3][4][5][6] Advanced ages, vertigo at the onset, degree of hearing loss, audiometric configuration, duration between onset, and treatment are known to be important for the prognosis. [2][3][4] On the other hand, the prevalence of hearing loss is reported to be high in males, Caucasians, smokers, and patients with older age, low educational level, diabetes mellitus (DM), and hypertension (HT).…”

Section: Introductionmentioning

confidence: 99%

The Prognostic Value of Circulating Inflammatory Cell Counts in Sudden Sensorineural Hearing Loss and the Effect of Cardiovascular Risk Factors

et al. 2020

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Objectives: Recent studies suggest that elevated neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are poor prognostic factors in sudden sensorineural hearing loss (SSNHL). We aimed to investigate the accuracy of this hypothesis by taking into account the effect of cardiovascular risk (CVR) factors. Methods: Medical records of 122 patients with SSNHL were reviewed retrospectively and grouped into 2 as; patients without CVR (group 1; n = 68) and patients having CVR (group 2; n = 54). Moreover, 60 control cases who did not have SSNHL were also included and grouped into 2 as; group 3 (n = 30) with CVR and group 4 (n = 30) healthy controls without having SSNHL or CVRs. Neutrophil (N), lymphocyte (L), platelet (Plt), NLR, and PLR between the groups and their relationship with the severity of hearing loss, recovery rates, and audiogram configurations were analyzed. Results: The highest N and NLR values were in group 1 and were significantly higher than the values of group 4 ( P < .05, P < .01). There was no significant relationship between the groups in terms of L, Plt, or PLR values. The highest NLR and PLR values were determined in SSNHL patients with mild hearing loss, complete recovery, and up-sloping audiogram configuration ( P > .05). Conclusions: Elevated levels of N and NLR may be considered as strong laboratory findings showing an inflammatory response in the diagnosis of SSNHL, but the presence of CVR factors does not seem to increase the inflammatory response in SSNHL as expected. In patients with SSNHL, NLR and PLR elevation may indicate better prognosis.

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“…2,3 Unfortunately, Fasano et al 1 did not report the treatment regimen in their case series and its temporal relationship with the laboratory assessment, but it is rational to assume that most of patients underwent steroid therapy. Blood samples were collected from the SSHL patients within 20 days from the onset of symptoms, 1 and that could hypothetically be before, during, or shortly after the steroid treatment. This is an important matter, as corticosteroids are known to elevate blood glucose levels, and more interestingly, may stimulate factor VIII secretion.…”

Section: Letter To the Editormentioning

confidence: 99%

In reference to Laboratory assessment of sudden sensorineural hearing loss: A case‐control study

Lovato

Filippis

2017

The Laryngoscope

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Laboratory assessment of sudden sensorineural hearing loss: A case‐control study

Abstract: 3b Laryngoscope, 127:2375-2381, 2017.

Cited by 59 publications

References 53 publications

Analysis of Clinical and Laboratory Findings of Idiopathic Sudden Sensorineural Hearing Loss

Analysis of Clinical and Laboratory Findings of Idiopathic Sudden Sensorineural Hearing Loss

The Prognostic Value of Circulating Inflammatory Cell Counts in Sudden Sensorineural Hearing Loss and the Effect of Cardiovascular Risk Factors

In reference to Laboratory assessment of sudden sensorineural hearing loss: A case‐control study

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