Laboratory assessment of the molluscicidal and cercariacidal activities of Balanites aegyptiaca

Molla, Eshetu; Giday, Mirutse; Erko, Berhanu

doi:10.1016/s2221-1691(13)60132-x

Cited by 25 publications

(15 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The extracted material was then concentrated to dryness under reduced pressure using Rota vapor at 45°C. The crude extract obtained was then refrigerated at -20 ºC until bioassay [ 14 , 22 ].…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Laboratory assessment of molluscicidal and cercariacidal effects of Glinus lotoides fruits

et al. 2014

Self Cite

View full text Add to dashboard Cite

BackgroundThe negative impact of synthetic molluscicides on the environment and their high cost necessitated search for an alternative approach of using plant extracts for the control of schistosomiasis. The objective of this study was, therefore, to evaluate aqueous and ethyl acetate crude extracts of Glinus lotoides fruits for their cercariacidal activity and molluscicidal effect against schistosome snail intermediate hosts.MethodsAssessment of the molluscicidal activity against Biomphalaria pfeifferi was made by immersion method in accordance with WHO guideline. The results of mortality were statistically analyzed using probit analysis. The attenuating effect of the plant on Schistosoma mansoni cercariae was determined using establishment of adult worms as a parasitological parameter post exposure.ResultsThe 24 and 48 hour-LC50 values for the aqueous extract of G. lotoides fruits were 47.1 and 44.1 mg/L, respectively, whereas that of ethyl acetate were 66.1 and 59.6 mg/L, respectively. The 24 and 48 hour LC90 values for the aqueous extract of G. lotoides fruits were 56.96 and 51.0 mg/L, respectively, while that of ethyl acetate were 77.2 and 70.0 mg/L, respectively. The in vitro cercariacidal activity was determined after 2 hrs of exposure to the aqueous plant extract. It was found out that the LC50 and LC90 values were 18.7 and 41.7 mg/L, respectively. Besides, infectivity of Schistosoma mansoni cercariae to mice was determined by exposing mice to cercariae pre-treated with the sub-lethal concentrations (3.7, 11.6 and 18.7 mg/L) of the aqueous extract. A significant reduction in worm burden in mice was obtained at 11.6 mg/L (p < 0.05). Moreover, the reduction in number of worms recovered was highly significant at 18.7 mg/L (p < 0.001).ConclusionsThe results showed that G. lotoides has molluscicidal activity against B. pfeifferi snails and cercariacidal activity against S. mansoni. Yet, further comprehensive evaluation is recommended for the possible use of G. lotoides against B. pfeifferi and the schistosome parasite.

show abstract

Section: Methodsmentioning

confidence: 99%

“…The most potent plant that has been known to have molluscicidal activity against snail intermediate hosts of schistosome is Phytolacca dodecandra [ 12 ]. Alternanthera sesselis [ 13 ], Balanites aegyptiaca [ 14 ] and Jatropha curcas [ 15 ] also lie among plants with molluscicidal activities.…”

Section: Introductionmentioning

confidence: 99%

Laboratory assessment of molluscicidal and cercariacidal effects of Glinus lotoides fruits

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…Though drug obtained from plant have limited chances of side but sometime improper dose can cause adverse effect of humans. Therefore toxicological study of various phytochemicals is must, Mariam et al (2013) studied the toxicological effect of B. aegyptiaca, and Jaundice, anthelmintic, rheumatism, CNS depressant, fungicidal, larvicidal, molluscicidal, insecticidal properties, it also used to remove intestinal parasites Neuwinger, 1996;Mohamed et al, 1999, Koko et al, 2000Koko et al, 2005;Chapagain et al, 2009;Patil et al, 2010;Abdulmalik et al, 2011;Shalaby et al, 2012 Stem/Root Bark Yellow fever, jaundice, antiangiogenic, antitumor, antioxidant, antimalarial, anti trypanocidal activity, cytotoxicity, mental diseases, diarrhea, epilepsy, treatment of Syphilis round worm infection, haemorrhoid, fish poison, antivinom against viper venom and syphilis Bukar et al, 2004;Katewa et al, 2004;Wurochekke & Nok, 2004;Koch et al, 2005;Gad et al, 2006;Ojo et al, 2006;Wufem et al, 2007;Ahmad Hassan et al, 2016 Fruit Skin diseases, sleeping sickness, oral hypoglycemia, cytotoxicity, antitumor effects, antioxidant, antifertility, insecticidal activity, anticonvulsant effect, cure mouth ulcer, boils and burns, whooping cough, effective antischistosomal remedy, act as an antidote to arrow poison Rao et al, 1997;Wiesman & Chapagain, 2003;Katewa et al, 2004;Koch et al, 2005;Koko et al, 2005;Gad et al, 2006;Ojo et al, 2006;Gnoula et al, 2008;Thirupathi et al, 2009;Al-Ghannam et al, 2013;Molla et al, 2013;Wabale, 2017 Seed Antitumor, anti-cancer antibacterial, antioxidant, antimalarial activity, effective antischistosomal remedy and cure cough, colic pain Wiesman & Chapagain, 2003;Bukar et al, 2004;Koko e...…”

Section: Toxicology Of Phytochemicalsmentioning

confidence: 99%

PHYTOCHEMISTRY AND PHARMACEUTICAL EVALUATION OF Balanites aegyptiaca: AN OVERVIEW

Thobaiti¹,

Zeid²

2018

JEBAS

View full text Add to dashboard Cite

Balanites aegyptiaca, is one of the awfully potent neglected wild plant species found mainly in both African and South Asian deserts. It is a historical and elegant folkloric medicinal plant due to its curative nature towards diverse fatal diseases, it is conventionally utilized in management of a variety of ailments such as jaundice, intestinal worm infection, wound healings, malaria, syphilis, epilepsy, dysentery, stomach aches, constipation, diarrhea, haemorrhoid and asthma. Biochemical analysis of plant extract revealed the presence of carbohydrates, lipids, proteins, alkaloids, flavonoids, saponins and organic acids. Due to the presence of these active ingredients, it is served as antioxidant, antihelminthic, antimicrobial (mainly the fixed oil) immunostimulant, anticarcinogenic, antidiabetic, contraceptive antifeedant, antiviral and molluscicidal activities. In conclusion, this review explored the presence of various secondary metabolites from various plant parts of Balanites aegyptiaca.

show abstract

“…According to the circadian rhythm, each snail species are then collected and placed individually into 24 or 48 well plates or in a test tube (1 ml of distilled or dechlorinated tap water/well or per tube). Each test tube or well plate can be exposed to artificial light for 30 min [39], 1 h [17], or 2 h [40–43]. The cercarial suspension is then collected, cleaned and concentrated by allowing to stand on ice for 30 to 60 min.…”

Section: Requirement For In Vitro Drug Screening Using Ntsmentioning

confidence: 99%

Mechanically produced schistosomula as a higher-throughput tools for phenotypic pre-screening in drug sensitivity assays: current research and future trends

Tekwu¹,

Anyan²,

Boamah³

et al. 2016

Biomark Res

View full text Add to dashboard Cite

It is crucial to develop new antischistosomal drugs since there is no vaccine and the whole world is relying on only a single drug for the treatment of schistosomiasis. One of the obstacles to the development of drugs is the absence of the high throughput objective screening methods to assess drug compounds efficacy. Thus for identification of new drug compounds candidates, fast and accurate in vitro assays are unavoidable and more research efforts in the field of drug discovery can target schistosomula. This review presents a substantial overview of the present state of in vitro drug sensitivity assays developed so far for the determination of anti-schistosomula activity of drug compounds, natural products and derivatives using newly transformed schistosomula (NTS). It highlights some of the challenges involved in in vitro compound screening using NTS and the way forward.

show abstract

Laboratory assessment of the molluscicidal and cercariacidal activities of Balanites aegyptiaca

Cited by 25 publications

References 8 publications

Laboratory assessment of molluscicidal and cercariacidal effects of Glinus lotoides fruits

Laboratory assessment of molluscicidal and cercariacidal effects of Glinus lotoides fruits

PHYTOCHEMISTRY AND PHARMACEUTICAL EVALUATION OF Balanites aegyptiaca: AN OVERVIEW

Mechanically produced schistosomula as a higher-throughput tools for phenotypic pre-screening in drug sensitivity assays: current research and future trends

Contact Info

Product

Resources

About