Laboratory Biomarkers in the Management of Patients With COVID-19

Weidmann, Maxwell D.; Ofori, Kenneth; Alex, J.

doi:10.1093/ajcp/aqaa205

Cited by 18 publications

(24 citation statements)

References 56 publications

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“…CRP levels >10 mg/l may aid in assessing the prognosis of patients with severe COVID-19 infection (29). In SARS-CoV-2 infection, the state of coagulopathy is presumed to be precipitated by the complex interaction between inflammatory and pro-thrombotic factors (30). Coronavirus causes endothelial inflammation and injury, resulting in disseminated intravascular coagulation.…”

Section: Discussionmentioning

confidence: 99%

Role of inflammatory and liver function markers in assessing the prognosis of patients with COVID‑19

Moorthy

Koshy

et al. 2021

World Acad Sci J

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused Coronavirus disease 2019 in early December, 2019. The disease begins as a respiratory disease with varied outcomes, from complete recovery to long-standing complications, such as respiratory distress, heart ailments and stroke. The present study was undertaken to identify the derangements in liver function and inflammatory status which may be used to diagnose the severity and thus assess the prognosis of patients with COVID-19 infection. The present study was conducted at a tertiary care teaching hospital. The study population included 456 patients with COVID-19, confirmed by the reverse transcription-PCR of nasopharyngeal swabs for SARS-CoV-2. Data were collected from patient files. The study was approved by the institutional ethics committee. Data are expressed based on the normality of distribution. Variables were compared and correlation analyses were performed. Receiver operating characteristics and the Youden index were applied to obtain cut-off values. The results revealed an increase in C-reactive protein (CRP), ferritin, D-dimer, lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and total bilirubin levels. In addition, there was evidence of leukocytosis, neutrophilia, lymphopenia and an increased neutrophil-to-lymphocyte ratio (NLR). The NLR exhibited an area under the curve of 0.77, with a cut-off value of 2.23 mg/l. Collectively, the findings of the present study demonstrate that the CRP, LDH, neutrophil and eosinophil counts along with the total leucocyte counts and absolute lymphocyte counts, NLR, erythrocyte sedimentation rate, D-dimer, ferritin and AST levels serve to predict the severity and prognosis of patients with COVID-19. AST appears to be a more sensitive marker than alanine aminotransferase. However, the De Ritis ratio, although not as sensitive as AST, may provide insight towards morbidity.

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Section: Discussionmentioning

confidence: 99%

Role of inflammatory and liver function markers in assessing the prognosis of patients with COVID‑19

Moorthy

Koshy

et al. 2021

World Acad Sci J

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“…It is recently recommended that severe disease in COVID-19 should apply only to those requiring ICU care. 6 This is one of the largest cohort studies so far on COVID-19 ICU patients. In our cohort, the mortality rate was 50% and we did not find any association between age and clinical outcome.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of Peripheral Blood T-lymphocytes Have Predictive Values for the Clinical Outcome of COVID-19 Patients in Intensive Care Unit

Zhang

Ziemba

et al. 2022

Clin Med�Insights�Pathol

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Background: Coronavirus disease 2019 (COVID-19) patients with severe disease had a high mortality rate. It’s imperative to identify risk factors associated with disease progression and prognosis. Immune responses played an important role in the host’s defense against the virus. We studied the dynamics of peripheral blood lymphocytes (PBLs) in relation to the clinical outcome in COVID-19 patients in intensive care unit (ICU). Design: This cohort included 342 COVID-19 patients who were admitted to ICU between February 1 and May 30, 2020, with 178 having follow-up PBL analysis. The patients were divided into a group that survived and an expired group. PBL analysis was performed by flow cytometry. Results: At time of initial flow analysis, there were no statistically significant differences in lymphocyte, T-cell and subsets, B-cell or natural killer (NK) cell counts between the 2 groups. However, during the ICU course, the surviving group demonstrated a full recovery of CD3+ T-cells, CD4+ T-cells, and CD8+ T-cells, with no significant change in B-cells, and a slight upward trend in NK-cells. In contrast, the expired group showed no recovery in T-cells (and subsets) and no significant changes in B-cells and NK-cells. We identified the earliest time points and cut-off values for T-cell subsets that predict clinical outcomes. Conclusion: The results of this study suggest that evaluation of PBL in COVID-19 patients could be valuable in the study of the immune responses to the disease and the prognostication of outcome.

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“…Despite most patients with COVID-19 overcome the disease experiencing only mild to moderate symptoms, severe patients may develop pneumonia, acute respiratory distress syndrome (ARDS) and in general a multi-pathologic and complex clinical picture. The most known pathologic features include cytokine release syndrome or "cytokine storm", lung, cardiovascular and kidney dysfunction, increased thrombotic risk, and down-regulation of adaptive cellular immunity (29). Altered levels of multiple circulating proteins have been observed particularly in severe patients, including the inflammatory IL-6 and CRP being elevated in severe and hospitalized patients (30).…”

Section: Discussionmentioning

confidence: 99%

Precise blood proteome profiling in an undiagnosed population with COVID-19

Fredolini

Dodig‐Crnković

Bendes

et al. 2021

Preprint

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Self-sampled blood provided valuable information about the COVID-19 seroprevalence in the general population. To enable an even deeper understanding of pathophysiological processes following SARS-CoV-2 infections, 276 circulating proteins were quantified by proximity extension assays in dried blood spots (DBS). Samples from undiagnosed individuals collected during the first wave of the pandemic were selected based on their serological immune response and matched on self-reported symptoms. We stratified these as seropositive (IgM+IgG+; N = 41) or seronegative (IgM-IgG-; N = 37), and to represent the acute (IgM+IgG-; N = 26) and convalescent phases (IgM-IgG+; N = 40). This revealed proteins from a variety of clinical processes including inflammation and immune response (MBL2, MMP3, IL2RA, FCGR2A, CCL5), haemostasis (GP1BA, VWF), stress response (ANG), virus entry (SDC4) or nerve regeneration (CHL1). The presented approach complements clinical surveys and enables a deep molecular and population-wide analysis of COVID-19 from blood specimens collected outside a hospital setting.

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Laboratory Biomarkers in the Management of Patients With COVID-19

Cited by 18 publications

References 56 publications

Role of inflammatory and liver function markers in assessing the prognosis of patients with COVID‑19

Role of inflammatory and liver function markers in assessing the prognosis of patients with COVID‑19

Dynamics of Peripheral Blood T-lymphocytes Have Predictive Values for the Clinical Outcome of COVID-19 Patients in Intensive Care Unit

Precise blood proteome profiling in an undiagnosed population with COVID-19

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