The study investigated the earthquake potential in Niger Delta region of Nigeria. A series of resonant column and bender element test was performed on compacted clay soil samples across the investigated Niger Delta States, which showed the influence of confinement on frequency, shear modulus, shear velocity and damping ratio. The confinement in clay was high. The frequency response increases with pressure increase. Also, the resonance column test at various confinements revealed changes in shear modulus, accelerometer output and damping ratio. Thus, there was high variation in the test parameters as confinement pressure was increased. Similarly, the bender element tests also showed that pressure has effect on shear wave-velocity, shear modulus and damping ratio confinement. Although, unlike Resonance Column tests, the shear modulus and shear wave-velocity generally increased as confinement pressure was increased, while for damping ratio it decreases as confinement pressure was increased. The variations in resonance column/binder element test parameters showed that the Niger Delta region, as an oil and gas area, is susceptible to earthquake. Therefore, continuous monitoring of oil exploration activities must be put in place.