Laboratory Diagnosis of Thyroid and Adrenal Disease

Lathan, Patty

doi:10.1016/j.cvsm.2022.08.005

Cited by 6 publications

(2 citation statements)

References 93 publications

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“…Serum TSH measurement is the most important test for diagnosing hypothyroidism, since increased serum levels are confirmatory, regardless of T3 and T4 values. 10 When measuring thyroid hormones, the measurement of free T4 is more reliable in maintaining its concentrations even if there are variations in the release and metabolism of total T3 and T4 or in the concentration of plasma proteins. 2,10,11 In the dog under study, TSH values by chemiluminescence were elevated and serum levels of free T4 by dialysis were below normal values for the canine species.…”

Section: Discussionmentioning

confidence: 99%

A case report of association between canine iatrogenic hyperadrenocorticism and hypothyroidism

Ruggero Errante

2024

JDVAR

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The canine hypothyroidism corresponds to a hormonal disorder, mainly caused by destruction of the thyroid gland, followed by idiopathic thyroid degeneration or idiopathic follicular atrophy, leading to a low production of the hormones thyroxine (T4) and triiodothyronine (T3). The canine iatrogenic hyperadrenocorticism consists of a disorder caused by the prolonged use of corticosteroids for therapeutic purposes, in most cases in allergic processes, such as canine atopy. In this case report, a twelve-year-old female Schnauzer was presented to the clinical facility with signs of apathy, polyphagia and non-pruritic bilateral symmetric alopecia that extended to the tip of the tail but sparing the head and limbs. Other clinical manifestations included polyuria, polydipsia, and bilateral keratoconjunctivitis sicca. The animal was submitted to the blood count, T4, T3, TSH dosage, dexamethasone suppression test, biochemical tests, and imaging tests. Exam results demonstrate the presence of hyperadrenocorticism and hypothyroidism. Since the use of corticosteroids in canine allergic diseases can lead to the development of hyperadrenocorticism, and hypothyroidism corresponds to the most common endocrinopathy in dogs, it is essential that the clinical veterinarian is able to identify these diseases early.

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Section: Discussionmentioning

confidence: 99%

A case report of association between canine iatrogenic hyperadrenocorticism and hypothyroidism

Ruggero Errante

2024

JDVAR

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“…Hypothyroidism is similarly diagnosed by a combination of clinical signs, serum chemistry, TT4, fT4 and TSH tests. While none of the enrolled dogs showed any of these clinical signs or laboratory abnormalities, it is possible that some of the dogs might have had an underlying endocrinopathy that interfered with response to MN 31 …”

Section: Discussionmentioning

confidence: 99%

Optimal microneedle length for hair regrowth in hair cycle arrest (alopecia X) in six dogs

Kang,

Kim,

Kang

et al. 2023

Veterinary Dermatology

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BackgroundHair cycle arrest (HCA) is a chronic alopecic disorder in dogs. Clinical responses vary and are often insufficient. Microneedling (MN) has been used as a successful treatment for HCA in dogs; ideal protocols have not yet been established.ObjectivesThe objective of the study was to compare the efficacy and safety of three needle lengths for MN in dogs with HCA.AnimalsSix unrelated client‐owned dogs, including five Pomeranians and one mixed‐breed dog, diagnosed with HCA.Materials and MethodsIndividual alopecic sites were divided into three sections. For each section, different lengths of needles (1, 2 and 3 mm) were used. Efficacy and safety were evaluated at 1, 3 and 6 months. Treated sections were monitored for 20 months.ResultsThree months after treatment with 3 mm needles, all sections showed hair regrowth. There was no hair regrowth in two of six sections treated with 2 mm needles, and four of six sections did not show a response to treatment with 1 mm needles. Two dogs developed transient pruritus. Five of six dogs had recurrent hair loss between 5 and 16 months of follow‐up.Conclusion and Clinical RelevanceMicroneedling using longer needles stimulated better hair regrowth in dogs with HCA. Alopecia relapsed in most dogs and minor pruritus occurred in some dogs.

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Changes in biomarkers of the redox status in whole blood and red blood cell lysates in canine hypothyroidism

González-Arostegui,

Muñoz-Prieto,

García-López

et al. 2024

Vet Res Commun

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Hypothyroidism is the most commonly diagnosed endocrine disease in dogs. The objective of this study was to evaluate the changes in the redox status in canine hypothyroidism using whole blood (WB) and red blood cell (RBCs) lysates. For this purpose, a panel of five antioxidants and five oxidants biomarkers was measured in WB and RBCs lysates of 30 dogs with hypothyroidism, 26 dogs with non-thyroidal illnesses and 15 healthy dogs. The antioxidants measured were cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of plasma (FRAP), Trolox equivalent antioxidant capacity (TEAC), thiol and paraoxonase type-1 (PON-1). Oxidants measured include the total oxidant status (TOS), peroxide-activity (POX-Act), reactive oxygen-derived metabolites (d-ROMs), advanced oxidation protein products (AOPP) and thiobarbituric acid reactive substances (TBARS). WB showed a significant decrease of the antioxidants CUPRAC, TEAC and thiol, and also an increase in TBARS and a decrease in AOPP in dogs with hypothyroidism compared to healthy dogs. Meanwhile, RBCs lysates showed a significant increase in FRAP and PON-1 in dogs with hypothyroidism. The changes in the redox biomarkers in this study show that WB in canine hypothyroidism had a higher number of changes in biomarkers of the redox status than RBCs lysates, making it a promising sample type for the evaluation of the redox status in this disease. In addition, WB is easier and simpler to process than RBCs lysates and unlike serum, it does not have any hemolysis interference.

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Laboratory Diagnosis of Thyroid and Adrenal Disease

Cited by 6 publications

References 93 publications

A case report of association between canine iatrogenic hyperadrenocorticism and hypothyroidism

A case report of association between canine iatrogenic hyperadrenocorticism and hypothyroidism

Optimal microneedle length for hair regrowth in hair cycle arrest (alopecia X) in six dogs

Changes in biomarkers of the redox status in whole blood and red blood cell lysates in canine hypothyroidism

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