Laboratory Evaluation of Intraocular Silicone Oil Removed After 23 Years in Situ

Liu, Yingna; Canbolat, Özgü; Bever, Greg; Stewart, Jay M.

doi:10.1097/iae.0000000000003123

Cited by 3 publications

(1 citation statement)

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“…Products of cell metabolism, such us cholesterol and fatty acids, have been detected in silicone oil after intraocular permanence. 13 , 14 A previous series verified the chemical stability of a high viscosity SO tamponed after prolonged intraocular permanence. 15 …”

Section: Discussionmentioning

confidence: 80%

Contamination Profile of Different Formulations of Silicone Oil Tamponade Before and After Intraocular Permanence for Rhegmatogenous Retinal Detachment

Bellucci,

Riboni,

Ricciotti

et al. 2024

Trans. Vis. Sci. Tech.

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Purpose The purpose of this study was to search for contaminants in silicone oil tamponades removed from eyes treated for retinal detachment, and to correlate chemical results with some clinical/functional parameters of the considered eyes. Methods We examined a sequential cohort of eyes grouped according to the tamponade received: (1) Siluron2000 (S2), (2) RS-OIL ECS5000 (S5), and (3) Densiron Xtra (DX). Samples were collected at the beginning of the scheduled removal and analyzed by untargeted headspace gas-chromatography mass spectrometry (HS-GC-MS). Visual acuity and optic coherence tomography assessments were obtained before and after the tamponade removal. Results Forty-one samples were analyzed: 22 belonging to the DX group, 13 to the S2 group, and 6 to the S5 group. For each group, a mixture of uninjected commercial preparation was analyzed as the reference. Different siloxanes and fluorinated compounds including perfluorodecalin (PFCL) were the most prevalent chemicals, found in 55% to 100% of the intraocular samples of the 3 groups. Some siloxanes were present also in the control matrices, whereas PFCL was only in the extracted tamponades. In the DX group, the concentration of hexamethylcyclotrisiloxane showed an inverse correlation trend with the duration of its permanence inside the eye ( P = 0.054). Different alkanes, propanol, and acetaldehyde were identified only in the control matrices. Conclusions Several contaminants including siloxanes were identified in the intraocular samples and in the control matrices. A time-related ocular uptake of some of these is conceivable. PFCL was also highly present but only in intraocular samples. Translational Relevance After intraocular permanence silicone oils (SOs) have various unlabeled contaminants with some relevant differences with the commercial formulation chemical profile.

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Section: Discussionmentioning

confidence: 80%