Laboratory Findings in Patients with Probable Dengue Diagnosis from an Endemic Area in Colombia in 2018

Cardenas, Jenny C.; Giraldo-Parra, Sandra Y; González, Marı́a Ujué; Gutierrez-Silva, Lady Y.; Jaimes-Villamizar, Lucy; Roa-Parra, Alba L; Carvajal, Daisy J; Valdivia, Hugo O.; Sánchez, Juan F.; Colpitts, Tonya M.; Londoño-Rentería, Berlin

doi:10.3390/v13071401

Cited by 6 publications

(3 citation statements)

References 44 publications

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“…(2019) 11 shows rise in haemoglobin compared to control group which have statistically significant association with dengue positive cases. While other two studied done by Mukker P et al (2018) 12 and Jenny C. Cardenas et al (2021) 13 does not show statistically significant association with dengue cases.…”

Section: Laboratory Parametersmentioning

confidence: 79%

Utility of Red Cell and Platelet Indices Evaluation of Severity of Dengue Infection

Patel¹,

Ranapurwala²,

Patel³

2022

Ann of Pathol and Lab Med

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Context: Dengue is the most common mosquito-borne viral illness in humans and transmitted by aedes aegypti. Infection may be asymptomatic or present with a mild febrile illness to a life-threatening shock syndrome and diagnosed by virological tests, serological tests, and complete blood count. Aim: The present study was undertaken to evaluate the role of red cell and platelet indices to assess disease activity and severity of dengue infection. Material and Methods: The present study was conducted at a tertiary level teaching hospital in Central Gujarat, India from November 2019 to August 2021.100 dengue positive cases and 100 controls (dengue negative case) were consecutively sampled. Epidemiological, clinical data and complete blood count were collected from online and offline registers of the Central Diagnostic Laboratory. Chi square test, independent sample T – test and Karl pearson coefficient of correlation were used for statistical analysis. Results: Dengue cases have frequently presented with fever 32.65% or fever with chills / rigor 66.33%, headache 37.76%, body ache 44.90% and bleeding manifestations like petechiae 5.10% and bleeding from gum, nose and rectum 5.15%. while, 18% cases have ascites and 07% cases were found to have pleural effusion in dengue positive cases. Haemoconcentration, fall in total WBC count, platelet count and plateletcrit have significant statistical association with severity of dengue infection. Platelet count was directly proportional to plateletcrit in dengue positive cases. Conclusion: Significant statistical association was presented between degree of leukopenia, thrombocytopenia, haemoconcentration and fall in plateletcrit with severity of dengue infection whereas plateletcrit has positive correlation with platelet count in dengue infection.

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Section: Laboratory Parametersmentioning

confidence: 79%

Utility of Red Cell and Platelet Indices Evaluation of Severity of Dengue Infection

Patel¹,

Ranapurwala²,

Patel³

2022

Ann of Pathol and Lab Med

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“…Gametocyte carriage was performed by qRT-PCR on the Pvs25 and Pvs230 genes of P. vivax parasites following the methods described elsewhere 43,44 . DENV diagnosis was performed using the Rapid Diagnostic Test, Cassette Dengue AG (Xerion) and confirmed by qRT-PCR 66 . We also tested 48 human samples collected from healthy volunteers living in Kansas to measure antibody levels against the peptides in non-endemic areas.…”

Section: Human Sample Collection and Diagnosismentioning

confidence: 99%

Mosquito Salivary Antigens and their Relationship to Dengue and P. <em>vivax </em>Malaria

Howell,

Olajiga,

Cardenas

et al. 2023

Preprint

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In tropical areas, simultaneous transmission of several vector-borne diseases is common due to ecological factors that are shared by arthropod vectors. Malaria and dengue virus, transmitted by Anopheles and Aedes mosquitoes, respectively, are among the top vector-borne diseases that cause significant morbidity and mortality in endemic areas. Notably, tropical areas often have suitable conditions for the co-existence of these mosquito species, highlighting the importance of identifying markers that accurately indicate the risk of acquiring each specific disease entity. Aedes are daytime-biting mosquitoes, while Anopheles preferentially bite during the night. These biting patterns raises the possibility of concurrent exposure to bites from both species. This pattern is important since mosquito saliva, deposited in the skin during blood feeding, induces immune responses that modulate pathogen establishment and infection. Previous studies have focused on characterizing such effects on the vector-pathogen interface for an individual pathogen and its mosquito vector. In this study, we evaluated associations between immune responses to salivary proteins from non-dengue and non-malaria vector mosquito species with clinical characteristics of malaria and dengue, respectively. Surprisingly, antibody responses against Anopheles antigens in dengue patients correlated with red blood cell count and hematocrit, while antibody responses against Aedes proteins were associated with platelet count in malaria patients. Our data indicate that concurrent exposure to multiple disease-carrying mosquito vectors and their salivary proteins with differing immunomodulatory properties could influence the transmission, pathogenesis, and clinical presentation of malaria, dengue fever, and other vector-borne illnesses.

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“…Transmission of Plasmodium and DENV often co-occur in tropical areas, mainly because of the overlap in the ecological niches preferred by the main vectors of these infections [35,36]. We, therefore, leveraged our ongoing malaria and dengue surveillance study in Norte de Santander, Colombia, to evaluate exposure to Anopheles and Aedes mosquito saliva and compare these data with blood parameters at diagnosis [37]. In this area, all DENV serotypes have circulated over the years.…”

Section: Introductionmentioning

confidence: 99%

Mosquito Salivary Antigens and Their Relationship to Dengue and P. vivax Malaria

Howell,

Olajiga,

Cardenas

et al. 2024

Pathogens

Self Cite

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In tropical areas, the simultaneous transmission of multiple vector-borne diseases is common due to ecological factors shared by arthropod vectors. Malaria and dengue virus, transmitted by Anopheles and Aedes mosquitoes, respectively, are among the top vector-borne diseases that cause significant morbidity and mortality in endemic areas. Notably, tropical areas often have suitable conditions for the co-existence of these mosquito species, highlighting the importance of identifying markers that accurately indicate the risk of acquiring each specific disease entity. Aedes are daytime-biting mosquitoes, while Anopheles preferentially bite during the night. These biting patterns raise the possibility of concurrent exposure to bites from both species. This is important because mosquito saliva, deposited in the skin during blood feeding, induces immune responses that modulate pathogen establishment and infection. Previous studies have focused on characterizing such effects on the vector–pathogen interface for an individual pathogen and its mosquito vector. In this study, we evaluated associations between immune responses to salivary proteins from non-dengue and non-malaria vector mosquito species with clinical characteristics of malaria and dengue, respectively. Surprisingly, antibody responses against Anopheles antigens in dengue patients correlated with red blood cell count and hematocrit, while antibody responses against Aedes proteins were associated with platelet count in malaria patients. Our data indicate that concurrent exposure to multiple disease-carrying mosquito vectors and their salivary proteins with differing immunomodulatory properties could influence the transmission, pathogenesis, and clinical presentation of malaria, dengue fever, and other vector-borne illnesses.

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Laboratory Findings in Patients with Probable Dengue Diagnosis from an Endemic Area in Colombia in 2018

Cited by 6 publications

References 44 publications

Utility of Red Cell and Platelet Indices Evaluation of Severity of Dengue Infection

Utility of Red Cell and Platelet Indices Evaluation of Severity of Dengue Infection

Mosquito Salivary Antigens and their Relationship to Dengue and P. <em>vivax </em>Malaria

Mosquito Salivary Antigens and Their Relationship to Dengue and P. vivax Malaria

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