Laboratory Investigation of Human Rhinovirus Infection in Cheonan, Korea

Abstract

Annually, millions of children die from respiratory virus infections. Human rhinovirus (HRV) is a causative agent of severe respiratory infections in young, elderly, and asthmatic patients with weak immunity. In this study, 9,010 respiratory virus specimens were collected from January 2012 to December 2018 at Dankook University Hospital, Cheonan and examined by real-time reverse transcription polymerase chain reaction. Twelve respiratory viruses were detected. The mean detection rate was 21.3% (N=1,920/9,010), and the mean age of HRV-positive patients was 6.5 years (median age: 1.6 years, range: 0.0∼96.0). The detection rate was the highest in July (32.4%) and the lowest in February (8.3%). When the detection rate was analyzed by age group, the detection rate was the second highest in patients aged 10∼19 years. The co-infection rate of HRV was 35.3%, and the most common combination was with Adenovirus. Respiratory virus infections are known to occur in children and elderly people with weak immunity. However, in this study, the detection rate was second highest in patients aged 10∼19 years. Indeed, the detection rate in this age group was more than 15%, except in January and February. These results suggested that steady-state studies on the infection patterns of HRV are required.

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“…These results may be due to the fact that HRV infections are more severe in winter and more hospitalizations occur during this season. Although all age groups were included, children aged between 2-<5 years showed a higher rate of HRV infection (21%), which was reported in previous studies (13). Our results, in line with previous reports, indicated that the detection rates gradually decrease with patient age (13,14).…”

“…Although all age groups were included, children aged between 2-<5 years showed a higher rate of HRV infection (21%), which was reported in previous studies (13). Our results, in line with previous reports, indicated that the detection rates gradually decrease with patient age (13,14). As seen in the results, there was no correlation between the disease status (inpatient and outpatient), and the HRV frequency.…”