Laboratory investigations including liver in polymyalgia rheumatica/giant cell arteritis

Kyle, V

doi:10.1016/s0950-3579(05)80066-4

Cited by 27 publications

(15 citation statements)

References 70 publications

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“…Slight elevations of transaminases or cholestatic parameters occur in about one third of patients with giant cell arteritis (2), but impairment of liver synthesis is uncommon and a progression to chronic liver disease has not been reported so far (3). As in the present case, treatment with steroids usually results in the normalization of hepatic enzymes (3).…”

Section: Digestive Diseases and Sciences Vol 51 No 1 (January 2006)mentioning

confidence: 61%

Hepatic Involvement in a Patient with Giant Cell Arteritis

et al. 2006

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Section: Digestive Diseases and Sciences Vol 51 No 1 (January 2006)mentioning

confidence: 61%

Hepatic Involvement in a Patient with Giant Cell Arteritis

et al. 2006

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“…Characteristic laboratory findings in addition to elevated erythrocyte sedimentation rate include normochromic normocytic anemia or hypochromic anemia. Liver function abnormalities are present in one‐third to one‐half of patients, particularly raised alkaline phosphates of liver origin 25 . Increased level of IgG and complement have been reported, as have increased levels of circulating immune complexes.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Internuclear Ophthalmoplegia: An Initial Presenting Sign of Giant Cell Arteritis

Ahmad

Zaman

1999

J American Geriatrics Society

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A 63-year-old man presented six days after the sudden onset of horizontal double vision. His left eye became divergent two days later. On initial examination he had bilateral internuclear ophthalmoplegia with weakness of adduction and abducting nystagmus. Convergence was weak but there were no other neuro-ophthalmic signs. Constitutional signs included confusion and unsteadiness on his feet. A provisional diagnosis of arteritis was made. His ESR was 92 mmlh and a superficial temporal artery biopsy confirmed the diagnosis of giant cell arteritis. After two weeks or oral prednisolone his eye movements returned to normal. There have been no further relapses. This would appear to be a unique presentation of giant cell arteritis. The causes of internuclear ophthalmoplegia are discussed along with a review of the ocular and neuro-ophthalmic signs of giant cell arteritis.

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“…4 The asymptomatic elevation in the alkaline phosphatase level in this patient indicated hepatic involvement, which has been observed in up to one third of cases of temporal arteritis. 5 In most patients with temporal arteritis or polymyalgia rheumatica, liverbiopsy specimens are normal or show minor, nonspecific changes; however, arteritis of the portal tract and septal vessels with cholangitis in adjacent bile ducts 6,7 and granulomatous hepatitis 8 have been reported. Liver involvement does not appear to affect the prognosis for patients with giant-cell arteritis, 9 and with the prompt initiation of glucocorticoid therapy, liver-enzyme levels tend to normalize quickly, as occurred in this case.…”

Section: Om Men Ta R Ymentioning

confidence: 99%