Laboratory Markers of Platelet Production and Turnover

Бодрова, В. В.; Shustova, O. N.; Хаспекова, С. Г.; Мазуров, А. В.

doi:10.1134/s0006297923140031

Cited by 2 publications

(1 citation statement)

References 101 publications

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“…Individuals in the top quartile of FIB exhibited an odds ratio of 6.0 (95% CI 3.5–10.4) in comparison to ones in the lowest group after age adjustment. Similarly, in a prospective investigation [ 24 ], FIB levels were assessed 6 months prior to study entry, and differences in FIB levels were observed between survivors and those who died. Moreover, another study explored the association of FIB with cardiac adverse events following AMI, reporting significantly higher FIB levels in individuals with a prior history of AMI or peripheral artery disease in comparison to those without prevalent CVD [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Fibrinogen to HDL-Cholesterol ratio as a predictor of mortality risk in patients with acute myocardial infarction

Jia,

Wu,

et al. 2024

Lipids Health Dis

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Background Acute myocardial infarction (AMI) is characterized by inflammation, oxidative stress, and atherosclerosis, contributing to increased mortality risk. High-density lipoprotein (HDL) takes a crucial part in mitigating atherosclerosis and inflammation through its diverse functionalities. Conversely, fibrinogen is implicated in the development of atherosclerotic plaques. However, the mortality risk predictive capacity of fibrinogen to HDL-cholesterol ratio (FHR) in AMI patients remains unexplored. This research aimed to evaluate the effectiveness of FHR for mortality risk prediction in relation to AMI. Methods A retrospective study involving 13,221 AMI patients from the Cardiorenal ImprovemeNt II cohort (NCT05050877) was conducted. Baseline FHR levels were used to categorize patients into quartiles. The assessment of survival disparities among various groups was conducted by employing Kaplan‒Meier diagram. Cox regression was performed for investigating the correlation between FHR and adverse clinical outcomes, while the Fine-Gray model was applied to evaluate the subdistribution hazard ratios for cardiovascular death. Results Over a median follow-up of 4.66 years, 2309 patients experienced all-cause death, with 1007 deaths attributed to cardiovascular disease (CVD). The hazard ratio (HR) and its 95% confidence interval (CI) for cardiac and all-cause death among individuals in the top quartile of FHR were 2.70 (1.99–3.65) and 1.48 (1.26–1.75), respectively, in comparison to ones in the first quartile, after covariate adjustment. Restricted cubic spline analysis revealed that FHR was linearly correlated with all-cause mortality, irrespective of whether models were adjusted or unadjusted (all P for nonlinearity > 0.05). Conclusion AMI patients with increased baseline FHR values had higher all-cause and cardiovascular mortality, regardless of established CVD risk factors. FHR holds promise as a valuable tool for evaluating mortality risk in AMI patients. Trial registration The Cardiorenal ImprovemeNt II registry NCT05050877.

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Section: Discussionmentioning

confidence: 99%