Laboratory methods and quality assurance in the Cardiovascular Health Study

Cushman, Mary; Cornell, Elaine; Howard, Paula; Bovill, Edwin G.; Tracy, Russell P.

doi:10.1093/clinchem/41.2.264

Cited by 412 publications

(204 citation statements)

References 8 publications

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“…Baseline serum albumin was measured by a Kodak Ektachem 700 analyser with reagents (Eastman Kodak, Rochester, NY, USA). 11 Hypoalbuminaemia was defined as serum albumin ≤3.5 g/dL. 12 Data on socio-demographic, clinical, sub-clinical, and laboratory variables were collected at baseline and have been previously described in detail.…”

Section: Hypoalbuminaemia and Other Baseline Measurementsmentioning

confidence: 99%

Hypoalbuminaemia and incident heart failure in older adults

Filippatos

Desai

Ahmed

et al. 2011

European J of Heart Fail

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AimsTo test the hypothesis that baseline hypoalbuminaemia is associated with incident heart failure (HF) in communitydwelling older adults. Methods and resultsOf the 5795 community-dwelling adults aged ≥65 years in the Cardiovascular Health Study, 5450 were free of centrally adjudicated prevalent HF at baseline, and also had data on baseline serum albumin. Of these, 599 (11%) had hypoalbuminaemia, defined as baseline serum albumin levels ≤3.5 mg/dL. Propensity scores for hypoalbuminaemia were calculated for each patient and used to assemble a matched cohort of 582 pairs of participants with and without hypoalbuminaemia, who were well balanced on 58 baseline characteristics. Using Cox regression models, we estimated the association of hypoalbuminaemia with centrally adjudicated incident HF during 9.6 years of median follow-up. Matched participants had a mean (+SD) age of 74 (+6) years, 62% were women, and 16% were African Americans. Incident HF occurred in 25 and 20% of matched participants with and without hypoalbuminaemia, respectively [hazard ratio when hypoalbuminaemia was compared with normoalbuminaemia, 1.40; 95% confidence interval, 1.05 -1.85; P ¼ 0.020]. Pre-match unadjusted, multivariable-adjusted, and propensity-adjusted hazard ratios (95% confidence intervals) for incident HF associated with hypoalbuminaemia were 1.33 (1.12-1.58; P ¼ 0.001), 1.33 (1.11-1.60; P ¼ 0.002), and 1.25 (1.04-1.50; P ¼ 0.016), respectively. The combined endpoint of incident HF or all-cause mortality occurred in 59 and 50% of matched participants with and without hypoalbuminaemia, respectively (hazard ratio, 1.33; 95% confidence interval, 1.11 -1.61; P ¼ 0.002). ConclusionsAmong community-dwelling older adults without HF, baseline hypoalbuminaemia was associated with increased risk of incident HF during 10 years of follow-up.--

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Section: Hypoalbuminaemia and Other Baseline Measurementsmentioning

confidence: 99%

Hypoalbuminaemia and incident heart failure in older adults

Filippatos

Desai

Ahmed

et al. 2011

European J of Heart Fail

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“…The F5 (Factor V Leiden; A1691G, R506Q) (de Ronde & Bertina, 1994) and the F2 (prothrombin) G20210A polymorphisms (Poort et al, 1996) were also assessed. Factor VIII coagulant activity (FVIII:C) was measured as previously reported (Cushman et al, 1995;Folsom et al, 1997). Plasma protein C level was only available in the ARIC sample and was measured as reported (Folsom et al, 2002c).…”

Section: Measurementsmentioning

confidence: 99%

Lack of association of soluble endothelial protein C receptor and PROCR 6936A/G polymorphism with the risk of venous thromboembolism in a prospective study

et al. 2009

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Summary Prior case–control studies reported that levels of the soluble form of the endothelial protein C receptor (sEPCR) were strongly controlled by the PROCR 6963A/G polymorphism and higher levels were a risk factor for venous thromboembolism (VTE). We sought to prospectively examine the association of sEPCR and the 6963A/G polymorphism with the incidence of VTE. The Longitudinal Investigation of Thromboembolism Etiology (LITE) pooled data from the Cardiovascular Health Study (CHS) and the Atherosclerosis Risk in Communities (ARIC) Study on men and women aged ≥45 years. A nested case–control study of 458 incident VTE and 1038 controls was performed. sEPCR levels were distributed trimodally according to 6963A/G polymorphism. Adjusting for age, sex and race, there was no overall association between sEPCR level and VTE: odds ratio (OR) [95% confidence interval] for highest versus lowest quartile = 1·17[0·86–1·59]. However, higher sEPCR was associated with VTE in non‐whites (OR = 1·84[1·05–3·22]) and women (OR = 1·51[1·01–2·26]). The 6963A/G polymorphism was not associated with VTE risk (OR = 0·93[0·70–1·25]). In conclusion, sEPCR levels and the PROCR 6963A/G polymorphism were not associated overall with increased risk of VTE.

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“…Details of blood collection, laboratory methods, and the fibrinogen assay have been reported. 13 C-reactive protein was measured in a high sensitivity assay developed at the University of Vermont. 14 All assays were conducted using blood collected at baseline.…”

Section: Study Population and Designmentioning

confidence: 99%