Laboratory surveillance of invasive Haemophilus influenzae disease in Argentina, 2011–2019

Efron, Adriana; Nápoli, Daniela; Neyro, Silvina; Juárez, María Del Valle; Moscoloni, Maria Alicia; Eluchans, Nahuel Sánchez; Regueira, Mabel; Lavayén, Silvina; Faccone, Diego; Santos, Mauricio

doi:10.1016/j.ram.2022.08.002

Cited by 5 publications

(3 citation statements)

References 41 publications

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“…al. confirmed that abroad, before the introduction of routine Hib vaccination, serotype B was responsible for nearly 4 out of 5 cases of invasive infections in children under 5 years of age and the occurrence of bacterial meningitis in this age group [53]. In Poland, on the other hand, despite the introduction of mandatory vaccination, the incidence of diseases caused by Hib is increasing every year.…”

Section: Hibmentioning

confidence: 80%

The Increasing Occurrence of Infectious Diseases in Childhood: Is It Linked with Declining Vaccination Rates Across Society?

Sztybór,

Kułak,

Palacz

et al. 2024

J Educ Health Sport

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Introduction. Childhood infectious diseases have been a significant medical problem, with a global increase in recent years. Modern diagnostic methods and new vaccinations are available. Poland is part of the WHO-coordinated global measles and rubella elimination program. Controversy surrounds mandatory and recommended vaccinations in Poland. There has been a concerning increase in the abandonment of vaccinating children, leading to a resurgence of infectious diseases. In 2024, the WHO reported a significant increase in measles cases in the European region, including in Poland. It's crucial to remind people of these diseases and warn them about the complications they bring. Aim of study. The aim of this study is to investigate the increasing occurrence of infectious diseases in childhood and examine the correlation with declining vaccination rates across society. Materials and methods. An unsystematic review of scientific literature was conducted, employing specific keywords such as „measles,” „pertussis,” „rubella,” „infectious diseases,” „vaccination,” and „hib.” The review was executed on the PubMed database, analyzing a total of 59 sources published until the conclusion of 2024. Conclusions. To control and eliminate infectious diseases, it is vital to maintain and improve vaccination rates. Policymakers and healthcare providers should prioritize immunization programs and address barriers to vaccine access. Further research is crucial to develop comprehensive strategies for increasing vaccination coverage and understanding vaccine-preventable diseases in modern public health challenges.

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Section: Hibmentioning

confidence: 80%

The Increasing Occurrence of Infectious Diseases in Childhood: Is It Linked with Declining Vaccination Rates Across Society?

Sztybór,

Kułak,

Palacz

et al. 2024

J Educ Health Sport

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“…Emergence of Hib-ID was mainly attributed to inadequate compliance with Hib vaccination schedule. 22 Data from France suggests that a simplified vaccination schedule with a hexavalent vaccine at age 2, 4 and 11 months is responsible for an emergence of Hib VF cases and correlates with lower antibody titers. 28 The number of cases analyzed is small and a difference in anti PRP titers was significant only in those 2 years old, which may reflect the shorter interval from the booster at 18 months in those with the 3 + 1 scheme.…”

Section: Discussionmentioning

confidence: 99%

“…Emergence of Hib-ID was mainly attributed to inadequate compliance with Hib vaccination schedule. 22…”

Section: Discussionmentioning

confidence: 99%

Haemophilus influenzae Type b Vaccine Failure in Portugal: A Nationwide Multicenter Pediatric Survey

Marques

Cunha

Bajanca-Lavado

2023

Pediatric Infectious Disease Journal

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Background: Despite the high effectiveness of the Haemophilus influenzae type b (Hib) vaccine in preventing invasive disease (ID) in children, Hib vaccine failures (VFs) cases may still occur. This study aimed to characterize the Hib-VF cases in Portugal in a 12-year period and trying to identify the possible associated risk factors. Methods: Prospective descriptive nationwide surveillance study. Bacteriologic and molecular studies were performed at the same Reference Laboratory. Clinical data were collected by the referring pediatrician. Results: Hib was identified in 41 children with ID and 26 (63%) were considered VF. Nineteen (73%) cases occurred in children less than 5 years old; 12 (46%) occurred before the Hib vaccine booster dose at 18 months of age. Comparing the first and the last 6-year periods of the study, the incidence rate of Hib, VF and total H. influenzae (Hi) ID significantly raised (P < 0.05). VF cases corresponded, respectively, to 13.5% (7/52) and 22% (19/88) of total Hi-ID cases (P = 0.232). Two children died due to epiglottitis and 1 acquired sensorineural hearing loss. Only 1 child had an inborn error of immunity. The immunologic workup performed in 9 children revealed no significant abnormalities. All 25 Hib-VF strains analyzed belonged to the same clonal complex 6. Conclusions: In Portugal, more than 95% of children are vaccinated against Hib, but severe Hib-ID cases still occur. No predisposing factors were clearly identified to justify the increased number of VF in recent years. Along with continued Hi-ID surveillance, Hib colonization and serologic studies should be implemented.

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Trends in serotype distribution and antimicrobial susceptibility pattern of invasive Haemophilus influenzae isolates from Brazil, 2009–2021

Zanella,

Bokermann,

Galhardo

et al. 2024

Int Microbiol

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Laboratory surveillance of invasive Haemophilus influenzae disease in Argentina, 2011–2019

Cited by 5 publications

References 41 publications

The Increasing Occurrence of Infectious Diseases in Childhood: Is It Linked with Declining Vaccination Rates Across Society?

The Increasing Occurrence of Infectious Diseases in Childhood: Is It Linked with Declining Vaccination Rates Across Society?

Haemophilus influenzae Type b Vaccine Failure in Portugal: A Nationwide Multicenter Pediatric Survey

Trends in serotype distribution and antimicrobial susceptibility pattern of invasive Haemophilus influenzae isolates from Brazil, 2009–2021

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