1982
DOI: 10.1093/clinids/4.2.351
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Laboratory Surveillance of Synergy Between and Resistance to Trimethoprim and Sulfonamides

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Cited by 19 publications
(6 citation statements)
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“…The data support the emergence of resistance and selection of resistant strains from a wide variety of genera. Selection of TMP-SMZ-resistant organisms may also select for populations resistant to other antibiotics, since factors specifying resistance to TMP-SMZ have been shown to be carried by plasmids which may also encode resistance to other antibiotics (4,20). Selection of MR staphylococci after the administration of a single antibiotic was also reported previously (12).…”
Section: Media For Recovery Of Mro In Rectal and Stool Culturessupporting
confidence: 56%
See 1 more Smart Citation
“…The data support the emergence of resistance and selection of resistant strains from a wide variety of genera. Selection of TMP-SMZ-resistant organisms may also select for populations resistant to other antibiotics, since factors specifying resistance to TMP-SMZ have been shown to be carried by plasmids which may also encode resistance to other antibiotics (4,20). Selection of MR staphylococci after the administration of a single antibiotic was also reported previously (12).…”
Section: Media For Recovery Of Mro In Rectal and Stool Culturessupporting
confidence: 56%
“…Within 4 years after the 1968 introduction of TMP-SMZ in Great Britain, resistance to TMP-SMZ in various clinical isolates was noted (2). Emergence of TMP-SMZ resistance in a wide variety of bacterial species has been demonstrated in the United States over the past decade (16,20). Resistance " Organisms included E. coli (13 isolates), Klebsiella pneumoniae (9 isolates), Enterobacter cloacae (12 isolates), Citrobacterfreundii (16 isolates), A. calcoaceticus var.…”
Section: Discussionmentioning
confidence: 99%
“…Changes in the frequency of TMP-resistant, sulfonamide-susceptible pathogens should reflect the selection pressure caused by TMP alone (63,84). One year after the introduction of TMP monotherapy in the United Kingdom in 1979, the occurrence of TMP-resistant, sulfonamide-susceptible enterobacterial strains was documented (84).…”
Section: Attempts To Suppress Development Andmentioning
confidence: 99%
“…Since 1968, TMP has been used in combination with SULs because the combination of TMPSULs was supposed to be synergistic in vitro (18). However, clinical experience suggests that TMP-SUL combinations have no clear synergism in vivo (2,16,112). In the 1970s, TMP alone came into use, first for the prophylaxis of urinary tract infections and later for the treatment of acute urinary tract infections as well (81).…”
Section: Introductionmentioning
confidence: 99%