Laboratory Tests of Hemostasis

I, Spector; Corn, Milton

doi:10.1001/archinte.1967.00290240099006

Cited by 33 publications

(8 citation statements)

References 6 publications

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“…9 Similar observation was also made by Donaldson et al in 1969. 7 In cirrhosis, Bleeders shows 100% elevation of PT by spector and corn et al 10 Rastogi P et al 11 show 87.5% elevation, D.S. Singh et al 8 shows 100% elevation and in-present study 100% elevation of PT is seen in bleeder.…”

Section: Discussionmentioning

confidence: 49%

“…Singh et al 8 shows 100% elevation and in-present study 100% elevation of PT is seen in bleeder. In Non-bleeders, Spector and corn et al 10 show elevation of PT in 22 cases (55%) out of 40 studied cases. Rastogi P shows 18% elevation and in present study 50% cases show elevation of PT.…”

Section: Discussionmentioning

confidence: 84%

“…This shows thrombocytopenia is shown by all workers mostly in similar ways. Low results are seen by Spector and Corn et al 10 and Roa PC et al 13 It may be due to variation in population of patients and number of cases studied. Harker LA and Finch CA stated that thrombocytopenia is seen mainly due to increased pool of platelets in spleen in cirrhosis with portal hypertension.…”

Section: Discussionmentioning

confidence: 90%

“…It is especially sensitive for factors XII, IX, XI, XIII, and platelet factor 3 adequacies. In cirrhosis, in bleeders Spector and corn et al 10 shows elevation in APTT with Kaolin in 9 cases (64.3%) cases. Rastogi P et al 11 shows elevation in 14 cases (77.7%) cases, D.S.…”

Section: Discussionmentioning

confidence: 94%

“…11 In viral hepatitis 40% cases show elevation in APTT with Ellegic acid by present study, similar observation were made by Clark R et al (1973 B). 12 In cirrhosis Bleeders according to Spector and Corn et al 10 thrombocytopenia was seen in 60% cases with range of 1.98 ± 0.24 lac/cumm, Roa PC et al 13 shows 70% cases with range of 1.72 ± 0.3, singh et al 8 show 100% cases with range 1.5 ± 0.5, Stein SF et al 14 show in range of 1.99 ± 0.46 lac/cumm. Rastogi P et al 11 show 100% cases with range of 1.83 ± 0.62 lac/cumm.…”

Section: Discussionmentioning

confidence: 97%

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Comparative study of coagulation profile in liver disease in tertiary care hospital

Patel¹,

Mangar²,

Patel³

2020

IJPO

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Introduction:The liver is the corner stone of the coagulation system and patients with liver disease are at a substantially increase risk of both thrombosis and haemorrhage. Liver acts as a reticulo endothelial system and regulates coagulation and fibrinolysis by removing these coagulation factors from the circulation. Coagulation disorders in liver disease are usually measured by the prolongation of global screening tests such as the prothrombin time and the activated partial thromboplastin time. Ingeneral, PT determines vitamin K dependent extrinsic factors VII, X, II, V and fibrinogen. The aPTT measures the activities of intrinsic and common pathways of coagulation cascade most sensitive to factor VIII, IX, XI, XII and those of the contact system. Aims and Objectives: To study the alteration in coagulation profile in various liver diseases, to evaluate the risk of bleeding in patients with liver disease and to study the association of coagulation abnormality with the extent of liver disease. Material and Methods:The study included 100 patients with liver diseases attending Medicine and Paediatric department clinics in a teaching tertiary care hospital. These patients were divided into three groups: (1) 40 cases of cirrhosis, (2) 40 cases of viral hepatitis and (3) 20 cases of obstructive jaundice. All these patients were screened for different coagulation tests like Prothrombin time (PT), Activated Partial Thromboplastin Time (APTT), Fibrinogen and Platelet count. Conclusion: Various abnormalities of coagulation tests vary greatly with different liver disorders, duration of the disorders, and their severity. There are more chances of bleeding when coagulation parameters are altered in cases of cirrhosis but more studies are required in this field to evaluate the thrombotic events seen in patients with liver diseases.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 97%

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