Labour analgesia; Molecular pathway and the role of nanocarriers: a systematic review

Kafshdooz, Leila; Kahroba, Houman; Kafshdooz, Taiebeh; Sheervalilou, Roghayeh; Pourfathi, Hojjat

doi:10.1080/21691401.2019.1573736

Cited by 10 publications

(7 citation statements)

References 69 publications

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“…Based on our findings, niosomal DFX showed a safer profile in normal human cells compared to cancerous cells (higher IC50). This is promising because, nowadays, nanotechnology-based strategies are focused on limiting the adverse drug side effects of drugs on healthy cells/tissues. , Meanwhile, in cancerous cells, niosomal DFX exhibited a much desirable cytotoxic activity than free DFX, indicated by lower IC50 in both cell lines. Among the cancerous cells, MCF7 cells were more sensitive to encapsulated DFX (IC50 = 3.018 and 5.041 μg/mL for MCF7 and Hela cells, respectively).…”

Section: Discussionmentioning

confidence: 99%

Preparation of pH-Responsive Vesicular Deferasirox: Evidence from In Silico, In Vitro, and In Vivo Evaluations

et al. 2021

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pH-sensitive nanocarriers can effectively deliver anticancer drugs to tumors and reduce the adverse effects of conventional chemotherapy. In this light, we prepared a novel pH-responsive deferasirox (DFX)-loaded vesicle and comprehensively performed in silico, in vitro, and in vivo studies to examine the properties of the newly synthesized formulation. Physiochemical assessment of the developed formulations showed that they have an average size (107 ± 2 nm), negative zeta potential (−29.1 ± 1.5 mV), high encapsulation efficiency (84.2 ± 2.6%), and a pH-responsive release. Using the molecular dynamics simulation, the structural and dynamic properties of ergosterol-containing niosomes (ST60/Ergo) in the presence of DFX molecules were analyzed and showed a good interaction between DFX and vesicle components. Cytotoxic assessment showed that niosomal DFX exhibited a greater cytotoxic effect than free DFX in both human cancer cells (MCF-breast cancer and Hela cervical cancer) and induced evident morphological features of apoptotic cell death. No marked difference between the ability of free and niosomal DFX was found in activating caspase-3 in Hela cells. Eight weeks of intraperitoneal administrations of free DFX at three doses caused a significant increase in serum biochemical parameters and liver lipid peroxidation. Treatment with 5 mg/kg dose of niosomal DFX caused a significant increase in serum creatinine (P < 0.05); however, other parameters remained unchanged. On the other hand, administration of niosomal DFX at the highest dose (10 mg/kg) significantly increased serum creatinine (P < 0.05), BUN, and serum liver enzymes compared to the control rats (P < 0.001). Based on the results, the application of pH-responsive DFX-loaded niosomes, as a novel drug delivery platform, may yield promising results in cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Preparation of pH-Responsive Vesicular Deferasirox: Evidence from In Silico, In Vitro, and In Vivo Evaluations

et al. 2021

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“…Smart syringe controls needle position and insertion using force sensor, linear actuator (load cell) and CPU as shown in Figure 2 and equations ( 1)-(3). [9][10][11] At this time, when the needle of the smart syringe passes through the skin, the force sensor (pressure sensor, F ps ) senses the pressure (friction of force, F fr ) because of the high resistance to the density (m) of the epidermis, and then transmits the data to the CPU. The CPU transmits a control command signal (current) to the actuator.…”

Section: Design Methods and Operation Processmentioning

confidence: 99%

Smart syringe using actuator and force sensor for epidural anesthesia injection

et al. 2021

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The anesthesia process in the epidural space is quite difficult as it requires a high level of skill. Therefore, a medical accident occurs, and intensive training is required. In order to reduce these medical accidents, medical technology is being developed, which provides safe and accurate treatment services. This paper proposes a smart syringe design for safe and accurate anesthesia in the epidural space. The smart syringe is designed to measure the electrical sensing waveform by using a sensor instead of the sense of the hand during anesthesia and show the position of the needle through external monitoring. To design a smart syringe, a force sensor, actuator, and CPU were used, and a 3D printer was used to produce the outer shape. An animal test was conducted to evaluate the performance test of the smart syringe, and satisfactory results were obtained by measuring the needle insertion process of the smart syringe and the position of the needle through the animal experiment.

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“…Nanotechnology has multiple applications with a scientific impact; however, the underlying pathways in interaction of NMs with biological systems at a molecular level still remain to be elucidated. These controversies raise concerns for utilizing nanoscale particles in targeted cancer therapies (Warheit 2010;Setyawati et al 2013b;Sheervalilou et al 2020;Changizi et al 2020;Sheervalilou et al 2021b;Shakeri-Zadeh et al 2020;Sheervalilou et al 2021a;Shirvalilou et al 2021;Kafshdooz et al 2019).…”

Section: Nanotechnologymentioning

confidence: 99%

An Updated Review on Implications of Autophagy and Apoptosis in Tumorigenesis: Possible Alterations in Autophagy through Engineered Nanomaterials and Their Importance in Cancer Therapy

et al. 2021

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Most commonly recognized as a catabolic pathway, autophagy is a perplexing mechanism through which a living cell can free itself of excess cytoplasmic components, i.e., organelles, by means of certain membranous vesicles or lysosomes filled with degrading enzymes. Upon exposure to external insult or internal stimuli, the cell might opt to activate such pathway through which it can gain control over the maintenance of intracellular components, and thus, sustain homeostasis by intercepting the formation of unnecessary structures or elimination of the already present dysfunctional or inutile organelles. Despite such appropriateness, autophagy, might also be considered a frailty for the cell, as it has been said to have a rather complicated role in tumorigenesis. A merit in the early stages of tumor formation, autophagy appears to be salutary due to its tumor-suppressing effects. In fact, several investigations on tumorigenesis have reported diminished levels of autophagic activity in tumor cells, which might result in transition to malignancy. On the contrary, autophagy has been suggested to be a seemingly favorable mechanism to progressed malignancies, as it contributes to survival of such cells. Based on the recent literature, this mechanism might also be activated upon the entry of engineered nanomaterials inside a cell, supposedly protecting the host from foreign materials. Accordingly, there is a good chance that therapeutic interventions for modulating autophagy in malignant cells using nanoparticles may sensitize cancerous cells to certain treatment modalities, e.g., radiotherapy. In this review, we will discuss the signaling pathways involved in autophagy, and the significance of the mechanism itself in apoptosis and tumorigenesis, while shedding light on possible alterations in autophagy through engineered nanomaterials, and the their potential therapeutic applications in cancer.

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Labour analgesia; Molecular pathway and the role of nanocarriers: a systematic review

Cited by 10 publications

References 69 publications

Preparation of pH-Responsive Vesicular Deferasirox: Evidence from In Silico, In Vitro, and In Vivo Evaluations

Preparation of pH-Responsive Vesicular Deferasirox: Evidence from In Silico, In Vitro, and In Vivo Evaluations

Smart syringe using actuator and force sensor for epidural anesthesia injection

An Updated Review on Implications of Autophagy and Apoptosis in Tumorigenesis: Possible Alterations in Autophagy through Engineered Nanomaterials and Their Importance in Cancer Therapy

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