Labrador retrievers and SUDEP: A simple theory that may have important applications

Scorza, Carla A.; Cavalheiro, Ésper A.; Calderazzo, Lineu; Scorza, Fúlvio A.

doi:10.1016/j.yebeh.2013.12.024

Cited by 2 publications

(5 citation statements)

References 22 publications

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“…In contrast, we observed significantly more CS development in the StE group (55 %) compared with the IdE group (31 %). This is similar to a previous study (IdE, 45.2 % vs. StE, 65.6 % [34]). The IVETF recommends that MRI and CSF analysis are performed in dogs with CS at epileptic seizure onset [6].…”

Section: Discussionsupporting

confidence: 93%

“…Although there had only been very small numbers reported, the risk of SUDEP in dogs is proposed to be similar to humans. In addition, canine SUDEP was previously reported in an Akita-inu [33] and Labrador Retriever [34], while here it was a Boston Terrier and a mixed-breed dog. Indeed, it is likely that SUDEP may occur in various breeds.…”

Section: Discussionmentioning

confidence: 66%

“…A few studies have reported SUDEP in veterinary medicine [33, 34], but its mechanisms remain unknown. In humans, patients at highest risk for SUDEP show occurrence of generalized tonic-clonic seizures, poor seizure control, a young age, and multiple AED treatment [35].…”

Section: Discussionmentioning

confidence: 99%

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Retrospective epidemiological study of canine epilepsy in Japan using the International Veterinary Epilepsy Task Force classification 2015 (2003–2013): etiological distribution, risk factors, survival time, and lifespan

et al. 2016

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BackgroundEpilepsy is the most common neurological disease in veterinary practice. However, contrary to human medicine, epilepsy classification in veterinary medicine had not been clearly defined until recently. A number of reports on canine epilepsy have been published, reflecting in part updated proposals from the human epilepsy organization, the International League Against Epilepsy. In 2015, the International Veterinary Epilepsy Task Force (IVETF) published a consensus report on the classification and definition of canine epilepsy. The purpose of this retrospective study was to investigate the etiological distribution, survival time of dogs with idiopathic epilepsy (IdE) and structural epilepsy (StE), and risk factors for survival time, according to the recently published IVETF classification. We investigated canine cases with epilepsy that were referred to our teaching hospital in Japan during the past 10 years, and which encompassed a different breed population from Western countries.ResultsA total of 358 dogs with epilepsy satisfied our etiological study criteria. Of these, 172 dogs (48 %) were classified as IdE and 76 dogs (21 %) as StE. Of these dogs, 100 dogs (consisting of 65 with IdE and 35 with StE) were included in our survival study. Median survival time from the initial epileptic seizure in dogs with IdE and StE was 10.4 and 4.5 years, respectively. Median lifespan of dogs with IdE and StE was 13.5 and 10.9 years, respectively. Multivariable analysis demonstrated that risk factors for survival time in IdE were high seizure frequency (≥0.3 seizures/month) and focal epileptic seizures.ConclusionsFocal epileptic seizures were identified as a risk factor for survival time in IdE. Clinicians should carefully differentiate seizure type as it is difficult to identify focal epileptic seizures. With good seizure control, dogs with IdE can survive for nearly the same lifespan as the general dog population. Our results using the IVETF classification are similar to previous studies, although some features were noted in our Japanese canine population (which was composed of mainly small-breed dogs), including a longer lifespan in dogs with epilepsy and a larger percentage of meningoencephalomyelitis of unknown origin in dogs with StE.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 66%

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Retrospective epidemiological study of canine epilepsy in Japan using the International Veterinary Epilepsy Task Force classification 2015 (2003–2013): etiological distribution, risk factors, survival time, and lifespan

et al. 2016

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“…Independent of the administered DS, no adverse event occurred more than once during 1 dietary period or was predominantly found associated to the type of DS. Seizure occurrences and disease‐related death throughout the study were not classified as adverse events and considered as sudden unexpected death in epilepsy 6,35,46 …”

Section: Resultsmentioning

confidence: 99%

“…Seizure occurrences and disease-related death throughout the study were not classified as adverse events and considered as sudden unexpected death in epilepsy. 6,35,46…”

Section: Adverse Events and Disease-related Deathmentioning

confidence: 99%

A multicenter randomized controlled trial of medium‐chain triglyceride dietary supplementation on epilepsy in dogs

Berk

Law

Packer

et al. 2020

Veterinary Internal Medicne

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Background: Medium-chain triglyceride (MCT) enriched diet has a positive effect on seizure control and behavior in some dogs with idiopathic epilepsy (IE).Objective: To evaluate the short-term efficacy of MCTs administered as an add-on dietary supplement (DS) to a variable base diet to assess seizure control and antiseizure drug's (ASD) adverse effect profiles.Animals: Twenty-eight dogs with International Veterinary Epilepsy Task Force Tier II (IVETF) level diagnosis of treated IE with 3 or more seizures in the last 3 months were used.Methods: A 6-month multicenter, prospective, randomized, double-blinded, placebocontrolled crossover trial was completed, comparing an MCT-DS with a control-DS.A 9% metabolic energy-based amount of MCT or control oil was supplemented to the dogs' diet for 3 months, followed by a control oil or MCT for another 3 months, respectively. Dogs enrolled in this study satisfied most requirements of IE diagnosis stated by the IVETF II level. If they received an oil DS or drugs that could influence the metabolism of the investigated DS or chronic ASD, the chronic ASD medication was adjusted, or other causes of epilepsy were found, the dogs were excluded from the study.Abbreviations: ASD, antiseizure drug; BHB, beta hydroxybutyric acid; C10, decanoic acid = capric acid; C8, octanoic acid = caprylic acid; DS, dietary supplement; IE, idiopathic epilepsy; ITTA, intention to treat analysis; IVETF II, International Veterinary Epilepsy Task Force Tier II; KBr, potassium bromide; LEV, levetiracetam; MBW, metabolic body weight; MCT, medium-chain triacylglyceride; ME, metabolic energy; PB, phenobarbital; QoL, quality of life; RER, resting energy requirement; RVC, Royal Veterinary College; VAS, visual analog score.

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Labrador retrievers and SUDEP: A simple theory that may have important applications

Cited by 2 publications

References 22 publications

Retrospective epidemiological study of canine epilepsy in Japan using the International Veterinary Epilepsy Task Force classification 2015 (2003–2013): etiological distribution, risk factors, survival time, and lifespan

Retrospective epidemiological study of canine epilepsy in Japan using the International Veterinary Epilepsy Task Force classification 2015 (2003–2013): etiological distribution, risk factors, survival time, and lifespan

A multicenter randomized controlled trial of medium‐chain triglyceride dietary supplementation on epilepsy in dogs

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