Labrenzbactin from a coral-associated bacterium Labrenzia sp.

Sharma, Amit Raj; Zhou, Tao; Harunari, Enjuro; Oku, Naohiko; Trianto, Agus; Igarashi, Yasuhiro

doi:10.1038/s41429-019-0192-x

Cited by 40 publications

(36 citation statements)

References 18 publications

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“…2019; Sharma et al . 2019). Antimicrobials produced by mutualistic bacteria located in the SML may also serve as the initial obstacle for corals against many potential pathogens (Fig.…”

Section: Secondary Metabolites From Cabmentioning

confidence: 99%

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Ecological and biotechnological importance of secondary metabolites produced by coral‐associated bacteria

et al. 2020

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Summary Symbiotic relationships between corals and their associated micro‐organisms are essential to maintain host homeostasis. Coral‐associated bacteria (CAB) can have different beneficial roles in the coral metaorganism, such as metabolizing essential nutrients for the coral host and protecting the coral from pathogens. Many CAB exert these functions via secondary metabolites, which include antibacterial, antifouling, antitumour, antiparasitic and antiviral compounds. This review describes how analysis of CAB has led to the discovery of secondary metabolites with potential biotechnological applications. The most commonly found types of secondary metabolites, antimicrobial and antibiofilm compounds, are emphasized and described. Recently developed methods that can be applied to enhance the culturing of CAB from shallow‐water reefs and the less‐studied deep‐sea coral reefs are also discussed. Last, we suggest how the combined use of meta‐omics and innovative growth‐diffusion techniques can vastly improve the discovery of novel compounds in coral environments.

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“…2019; Sharma et al . 2019). Antimicrobials produced by mutualistic bacteria located in the SML may also serve as the initial obstacle for corals against many potential pathogens (Fig.…”

Section: Secondary Metabolites From Cabmentioning

confidence: 99%

“…2013; Sharma et al . 2019). Other examples include CAB secondary metabolites with cytotoxic activity against tumour cell lines (Lombó et al .…”

Section: Introductionmentioning

confidence: 99%

Ecological and biotechnological importance of secondary metabolites produced by coral‐associated bacteria

et al. 2020

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“…The cytotoxicity assay was carried out in a similar manner as described in [17]. P388 murine leukemia cells were maintained in RPMI-1640 medium containing ʟ-glutamine (product no.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

“…As a part of our ongoing screening program to discover new natural products from coral-associated bacteria, we have recently reported a catecholate siderophore, labrenzbactin, from an alphaproteobacterium Labrenzia [17] and an unsaturated fatty acid with unique methylation pattern from a gammaproteobacterium Microbulbifer [18]. Herein, we report the fermentation, isolation, structure determination, and bioactivity of two new keto fatty acids, (6E,8Z)-5-oxo-6,8-tetradecadienoic acid (1) and its (6E,8E)-isomer 2, from a coral-associated actinomycete Micrococcus sp.…”

Section: Introductionmentioning

confidence: 99%

Two antibacterial and PPARα/γ-agonistic unsaturated keto fatty acids from a coral-associated actinomycete of the genus Micrococcus

Sharma¹,

Harunari²,

Oku³

et al. 2020

Beilstein J. Org. Chem.

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A pair of geometrically isomeric unsaturated keto fatty acids, (6E,8Z)- and (6E,8E)-5-oxo-6,8-tetradecadienoic acids (1 and 2), were isolated from the culture broth of an actinomycete of the genus Micrococcus, which was associated with a stony coral, Catalaphyllia sp. Their chemical structures were elucidated by spectroscopic analysis including NMR and MS, with special assistance of spin system simulation studies for the assignment of an E geometry at C8 in 2. As metabolites of microbes, compounds 1 and 2 are unprecedented in terms of bearing a 2,4-dienone system. Both 1 and 2 showed antibacterial activity against the plant pathogen Rhizobium radiobacter and the fish pathogen Tenacibaculum maritimum, with a contrasting preference that 1 is more effective to the former strain while 2 is so to the latter. In addition, compounds 1 and 2 displayed agonistic activity against peroxisome proliferator-activated receptors (PPARs) with an isoform specificity towards PPARα and PPARγ.

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“…Sea anemone Radianthus crispus was purchased from an aquarium vendor in Nagasaki, Japan. Strain SI9 was isolated from its outer tissue specimen according to the method described previously [19], and identified as a member of genus Vibrio on the basis of 98.6% similarity in the 16S rRNA gene sequence (1458 nucleotides;…”

Section: Biological Materialsmentioning

confidence: 99%

Three new O-isocrotonyl-3-hydroxybutyric acid congeners produced by a sea anemone-derived marine bacterium of the genus Vibrio

Li¹,

Harunari²,

Zhou³

et al. 2020

Preprint

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Liquid cultures of Vibrio sp. SI9, isolated from outer tissue of sea anemone Radianthus crispus, was found to produce three new O-isocrotonyl-3-hydroxybutyric acid derivatives, O-isocrotonyl-3-hydroxypentanoic acid (1), O-isocrotonyl-3-hydroxyhexanoic acid (2), and O-(Z)-2-hexenoyl-3-hydroxybutyric acid (3), together with known O-isocrotonyl-3-hydroxybutyric acid (4). The structures of 1-3 were established by spectroscopic analyses of NMR and mass spectrometry coupled with anisotropy-based chiral analysis, revealing the same (R)-configurations for all congeners 1-4. Compounds 1-4 were weakly growth-inhibitory against a marine fish ulcer pathogenic bacterium, Tenacibaculum maritimum NBRC16015.

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Labrenzbactin from a coral-associated bacterium Labrenzia sp.

Cited by 40 publications

References 18 publications

Ecological and biotechnological importance of secondary metabolites produced by coral‐associated bacteria

Ecological and biotechnological importance of secondary metabolites produced by coral‐associated bacteria

Two antibacterial and PPARα/γ-agonistic unsaturated keto fatty acids from a coral-associated actinomycete of the genus Micrococcus

Three new O-isocrotonyl-3-hydroxybutyric acid congeners produced by a sea anemone-derived marine bacterium of the genus Vibrio

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