Labyrinthin Expression Is Associated with Poor Prognosis in Patients with Non-Small-Cell Lung Cancer

Ma, Weijie; Zeng, Jie; Montoya, Dennis; Toomey, Kyra; Zhou, Carol L. Ecale; Chen, Shuai; Liu, Dingning; Babich, Michael; Radosevich, James A.; Li, Tianhong

doi:10.3390/cancers15030924

Cited by 2 publications

(3 citation statements)

References 26 publications

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“…In patients with metastatic NSCLC under PD-1 inhibitors treatment, serum lactate dehydrogenase and C-reactive protein concentrations were significantly associated with overall survival 32 . In a recent study, the expression of labyrinthin, a novel cancer neoantigen, was suggested to be associated with prognosis in NSCLC patients 33 . Moreover, the elevated transcription of CPEB4, or IRF4, in peripheral blood was associated with poor survival 34 .…”

Section: Discussionmentioning

confidence: 99%

mRNA markers associated with malignant pleural effusion

Hsu

Chang

Hwang

et al. 2023

Sci Rep

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Malignant pleural effusions (MPE) commonly result from malignant tumors and represent advanced-stage cancers. Thus, in clinical practice, early recognition of MPE is valuable. However, the current diagnosis of MPE is based on pleural fluid cytology or histologic analysis of pleural biopsies with a low diagnostic rate. This research aimed to assess the diagnostic ability of eight previously identified Non-Small Cell Lung Cancer (NSCLC)-associated genes for MPE. In the study, eighty-two individuals with pleural effusion were recruited. There were thirty-three patients with MPE and forty-nine patients with benign transudate. mRNA was isolated from the pleural effusion and amplified by Quantitative real-time PCR. The logistic models were further applied to evaluate the diagnostic performance of those genes. Four significant MPE-associated genes were discovered in our study, including Dual-specificity phosphatase 6 (DUSP6), MDM2 proto-oncogene (MDM2), Ring finger protein 4 (RNF4), and WEE1 G2 Checkpoint Kinase (WEE1). Pleural effusion with higher expression levels of MDM2 and WEE1 and lower expression levels of RNF4 and DUSP6 had a higher possibility of being MPE. The four-gene model had an excellent performance distinguishing MPE and benign pleural effusion, especially for pathologically negative effusions. Therefore, the gene combination is a suitable candidate for MPE screening in patients with pleural effusion. We also identified three survival-associated genes, WEE1, Neurofibromin 1 (NF1), and DNA polymerase delta interacting protein 2 (POLDIP2), which could predict the overall survival of patients with MPE.

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Section: Discussionmentioning

confidence: 99%

mRNA markers associated with malignant pleural effusion

Hsu

Chang

Hwang

et al. 2023

Sci Rep

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“…LAB expression is an independent poor prognostic factor for LUAD. 1 High prevalence of LAB expression was also found in breast cancer samples (95.8%, 93/97). There was no significant difference in the LAB expression among the ER, PR, and HER2 positive subgroups.…”

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confidence: 89%

“…IHC assay was used to detect LAB expression on 11 out of 12 (91.7%) patients screened for the phase I trial. Tumor origins included colon or rectum (8), ovarian (1), scalp (1), and prostate (1). LAB RNA was expressed in both oncogene-driven and nononcogene-driven adenocarcinomas.…”

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confidence: 99%