Lacidipine attenuates caffeine-induced anxiety-like symptoms in mice: Role of calcium-induced oxido-nitrosative stress

Khurana, Kunal; Bansal, Nitin

doi:10.1016/j.pharep.2019.07.008

Cited by 15 publications

(6 citation statements)

References 33 publications

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“…In addition to its established regulatory role in vascular biology, lacidipine has demonstrated therapeutic e cacy across diverse animal models of conditions such as anxiety, depression, antibacterial effects, and ovarian cancer [12][13][14][15] . In these models, the therapeutic dosage of lacidipine typically ranged from 2 to 10 mg/kg administered orally on a daily basis.…”

Section: Discussionmentioning

confidence: 99%

Lacidipine inhibits NF-κB and Notch pathways and mitigates DSS-induced colitis

Yu,

Li,

Tao

et al. 2024

Preprint

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Ulcerative colitis (UC) is a chronic inflammatory condition affecting the colon, with its global incidence on the rise, yet effective treatments remain limited. Through screening using an NF-kB promoter dual fluorescence reporter system, we identified the anti-hypertension drug lacidipine as capable of effectively inhibiting p65 and IκBα phosphorylation. In a murine model of dextran sulfate sodium (DSS)-induced colitis, lacidipine demonstrated the ability to mitigate colon lesions and reduce inflammation markers. Target analysis revealed a notable enrichment of the Notch signal. Furthermore, lacidipine treatment inhibited both NF-kB and Notch activation in the colon stimulated by DSS. In summary, our study highlights lacidipine's potential in alleviating UC, presenting it as a promising candidate drug for UC treatment.

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Section: Discussionmentioning

confidence: 99%

Lacidipine inhibits NF-κB and Notch pathways and mitigates DSS-induced colitis

Yu,

Li,

Tao

et al. 2024

Preprint

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“…Studies have demonstrated that caffeine intake activates calcium channels and increases anxiety‐like behaviors. Therefore, this model can apply to the screening of antianxiety novel agents for the L‐type Ca channel 27 . The LPS‐induced model simulates anxiety induced by dysbiosis of the gut microbiome.…”

Section: Current Animal Models Of Anxietymentioning

confidence: 99%

Recent advances in anxiety disorders: Focus on animal models and pathological mechanisms

Zhao,

Zhou,

Liu

et al. 2023

Anim Models and Exp Med

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Anxiety disorders have become one of the most severe psychiatric disorders, and the incidence is increasing every year. They impose an extraordinary personal and socioeconomic burden. Anxiety disorders are influenced by multiple complex and interacting genetic, psychological, social, and environmental factors, which contribute to disruption or imbalance in homeostasis and eventually cause pathologic anxiety. The selection of a suitable animal model is important for the exploration of disease etiology and pathophysiology, and the development of new drugs. Therefore, a more comprehensive understanding of the advantages and limitations of existing animal models of anxiety disorders is helpful to further study the underlying pathological mechanisms of the disease. This review summarizes animal models and the pathogenesis of anxiety disorders, and discusses the current research status to provide insights for further study of anxiety disorders.

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“…These last data are important because a reduction in anxiety-like behaviors in the elevated plus maze (EPM) test was related to high levels of BDNF, which was accompanied by greater expression of TrkB and BDNF m RNA in brain structures such as the HP, PFC, and amygdala [ 56 ]. Interestingly, the anxiolytic-like activity produced by diazepam has been associated with the restoration of normal levels of antioxidant enzymes, such as SOD and CAT, as well as a reduction in nitrite concentration in the mouse brain [ 57 ]. Therefore, alterations in peripheral and central enzymatic antioxidant systems can generate oxidative stress and contribute to anxiety- and depression-like behaviors.…”

Section: Biochemical and Pharmacological Activity Of Flavonoid Chrysinmentioning

confidence: 99%

Pharmacological, Neurochemical, and Behavioral Mechanisms Underlying the Anxiolytic- and Antidepressant-like Effects of Flavonoid Chrysin

et al. 2022

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Chrysin (5,7-dihydroxyflavone) is a flavonoid isolated from plants, such as Passiflora coerulea, Passiflora incarnata, and Matricaria chamomilla. This natural molecule exerts diverse pharmacological effects, which includes antioxidant, anti-inflammatory, anti-cancer, neuroprotective, and anti-apoptotic effects. Additionally, in brain structures, such as the hippocampus, prefrontal cortex, raphe nucleus, and striatum, involved in the physiopathology of anxiety and depression disorders, several neuropharmacological activities, including the activation of neurotransmitter systems (GABAergic, serotonergic, dopaminergic, and noradrenergic), neurotrophic factors, such as brain-derived neurotrophic factor and the nerve growth factor, and some signaling pathways are affected. The results showed that the anxiolytic and antidepressant-like effects of chrysin occurs through its interaction with specific neurotransmitter systems, principally the GABAergic and the serotonergic, and activation of other neurotrophic factors. However, it is not possible to discard the antioxidant and anti-inflammatory activities of chrysin while producing its anxiolytic- and antidepressant-like effects. Although these results have been obtained principally from pre-clinical research, they consistently demonstrate the potential therapeutic use of flavonoid chrysin as an anxiolytic and antidepressant agent. Therefore, this flavonoid could be considered as a promising novel therapy for anxiety and depression disorders.

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Lacidipine attenuates caffeine-induced anxiety-like symptoms in mice: Role of calcium-induced oxido-nitrosative stress

Cited by 15 publications

References 33 publications

Lacidipine inhibits NF-κB and Notch pathways and mitigates DSS-induced colitis

Lacidipine inhibits NF-κB and Notch pathways and mitigates DSS-induced colitis

Recent advances in anxiety disorders: Focus on animal models and pathological mechanisms

Pharmacological, Neurochemical, and Behavioral Mechanisms Underlying the Anxiolytic- and Antidepressant-like Effects of Flavonoid Chrysin

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