Lacidipine attenuates reserpine-induced depression-like behavior and oxido-nitrosative stress in mice

Khurana, Kunal; Bansal, Nitin

doi:10.1007/s00210-019-01667-6

Cited by 22 publications

(16 citation statements)

References 35 publications

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“…Therefore, one of the significant side effects of reserpine treatment is the development of depressive behavior which has been used in preclinical studies-reserpine serves as an agent that induces depression-like behavior in laboratory animals [94,95]. Though previously reserpine was mainly applied in rodent models, lately it has also been used in Danio rerio.…”

Section: Different Methods To Induce Depression-like Behavior In Zebrafishmentioning

confidence: 99%

“…Its mechanism of action involves an irreversible blockage of the vesicular monoamine transporter which in consequence results in reduced levels of monoamines in the brain. Therefore, one of the significant side effects of reserpine treatment is the development of depressive behavior which has been used in preclinical studies—reserpine serves as an agent that induces depression-like behavior in laboratory animals [ 94 , 95 ]. Though previously reserpine was mainly applied in rodent models, lately it has also been used in Danio rerio .…”

Section: Zebrafish In Neurological Studiesmentioning

confidence: 99%

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Zebrafish as an Animal Model for Testing Agents with Antidepressant Potential

Lachowicz

Niedziałek

Rostkowska³

et al. 2021

Life

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Depression is a serious mental disease that, according to statistics, affects 320 million people worldwide. Additionally, a current situation related to the COVID-19 pandemic has led to a significant deterioration of mental health in people around the world. So far, rodents have been treated as basic animal models used in studies on this disease, but in recent years, Danio rerio has emerged as a new organism that might serve well in preclinical experiments. Zebrafish have a lot of advantages, such as a quick reproductive cycle, transparent body during the early developmental stages, high genetic and physiological homology to humans, and low costs of maintenance. Here, we discuss the potential of the zebrafish model to be used in behavioral studies focused on testing agents with antidepressant potential.

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Section: Different Methods To Induce Depression-like Behavior In Zebrafishmentioning

confidence: 99%

Section: Zebrafish In Neurological Studiesmentioning

confidence: 99%

Zebrafish as an Animal Model for Testing Agents with Antidepressant Potential

Lachowicz

Niedziałek

Rostkowska³

et al. 2021

Life

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“…The depletion of catecholamines (norepinephrine, epinephrine, and dopamine) and serotonin (5-HT) leads to morphological changes in the brain of tested animals and has good face validity due to the appearance of the depression-like phenotype [145][146][147][148]157]. This model is widely used in preclinical studies to evaluate the antidepressant effect of new developing drugs and plant compounds [149][150][151][152][153][154] due to the short-term time and good predictive validity [147,155]. However, reserpine treatment produces motor impairments mimicking Parkinson disease dyskinesia, increased nociceptive sensitization and hypothermia and has high mortality rate [148,[155][156][157].…”

Section: Pharmacological Models 431 Reserpine Induced Depression Modelmentioning

confidence: 99%

Animal Models of Depression: What Can They Teach Us about the Human Disease?

2021

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Depression is apparently the most common psychiatric disease among the mood disorders affecting about 10% of the adult population. The etiology and pathogenesis of depression are still poorly understood. Hence, as for most human diseases, animal models can help us understand the pathogenesis of depression and, more importantly, may facilitate the search for therapy. In this review we first describe the more common tests used for the evaluation of depressive-like symptoms in rodents. Then we describe different models of depression and discuss their strengths and weaknesses. These models can be divided into several categories: genetic models, models induced by mental acute and chronic stressful situations caused by environmental manipulations (i.e., learned helplessness in rats/mice), models induced by changes in brain neuro-transmitters or by specific brain injuries and models induced by pharmacological tools. In spite of the fact that none of the models completely resembles human depression, most animal models are relevant since they mimic many of the features observed in the human situation and may serve as a powerful tool for the study of the etiology, pathogenesis and treatment of depression, especially since only few patients respond to acute treatment. Relevance increases by the fact that human depression also has different facets and many possible etiologies and therapies.

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“…Lacidipine (TCI Chemicals, Chennai, India) at doses 0.3, 1, and 3 mg/kg (i.p.) was injected at a dose-volume of 3 ml/kg once daily for 14 consecutive days initiating from day 1 (Khurana and Bansal 2019a;Bellosta et al 2001). Sertraline (Zee Laboratories, Ponta Sahib, India), a selective serotonin reuptake inhibitor (SSRI), was taken as a standard drug in the current protocol and was administered (40 mg/kg, i.p.)…”

Section: Experimental Animalsmentioning

confidence: 99%

“…In our previous studies, lacidipine (1 and 3 mg/kg, i.p.) was able to reduce the symptoms of depression and anxiety in different animal models (Khurana and Bansal 2019a;Khurana and Bansal 2019b). The existing literature indicates that treatment with Ca 2+ antagonists may alleviate the nicotine dependence and withdrawal symptoms (Biala et al 2014;Katsura et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Lacidipine Attenuates Symptoms of Nicotine Withdrawal in Mice

Khurana

Kumar

Bansal³

2021

Neurotox Res

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Nicotine-withdrawal after daily exposure manifests somatic and affective symptom including a range of cognitive de cits. Earlier studies suggested participation of L-type calcium channels (LTCCs) in development of nicotine dependence and expression of withdrawal signs. An upsurge in Ca 2+ -induced oxidative stress in brain underlies the biochemical events and behavioral signs of nicotine-withdrawal.The present study is aimed to explore the effects of lacidipine (LTCC antagonist) against nicotinewithdrawal. Swiss albino mice were administered (−)-nicotine hydrogen tartrate (3.35 mg/kg, t.i.d.) from day 1 to 7 and alongside lacidipine (0.3, 1 and 3 mg/kg, i.p.) given from day 1 to 14. Somatic withdrawal signs were noted 48 h after last dose of nicotine. Bay-K8644 (LTCC agonist) was administered in mice subjected to nicotine-withdrawal and lacidipine (3 mg/kg) treatments. Behavioral tests of memory, anxiety, and depression were conducted on day 13 and 14 to assess the effects of lacidipine on affective symptoms of nicotine-withdrawal. Biomarkers of oxido-nitrosative were quanti ed in the whole brain.Nicotine-withdrawal signi cantly enhanced somatic signs and symptoms of anxiety, depression, and memory impairment in mice. Lacidipine (1 and 3 mg/kg) attenuated nicotine-withdrawal induced somatic symptoms and also ameliorated behavioral abnormalities. Nicotine-withdrawal triggered an upsurge in brain lipid peroxidation, total nitrite content, and decline in antioxidants and these effects were attenuated by lacidipine. Bay-K8644 signi cantly abolished improvement in somatic and affective symptoms, and antioxidant effects by lacidipine in mice subjected to nicotine-withdrawal. Lacidipine mitigated nicotinewithdrawal triggered somatic and affective symptoms owing to decrease in brain oxido-nitrosative stress.

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Lacidipine attenuates reserpine-induced depression-like behavior and oxido-nitrosative stress in mice

Cited by 22 publications

References 35 publications

Zebrafish as an Animal Model for Testing Agents with Antidepressant Potential

Zebrafish as an Animal Model for Testing Agents with Antidepressant Potential

Animal Models of Depression: What Can They Teach Us about the Human Disease?

Lacidipine Attenuates Symptoms of Nicotine Withdrawal in Mice

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