Lack of an Association between Neutrophil-to-Lymphocyte Ratio and PSA Failure of Prostate Cancer Patients Who Underwent Radical Prostatectomy

Maeda, Yoko; Kawahara, Takashi; Koizumi, Mitsuyuki; Ito, Hiroki; Kumano, Yohei; Ohtaka, Mari; Kondo, Takuya; Mochizuki, Takashi; Hattori, Yusuke; Teranishi, Jun Ichi; Yumura, Yasushi; Miyoshi, Yasuhide; Yao, Masahiro; Miyamoto, Hiroshi; Uemura, Hiroji

doi:10.1155/2016/6197353

Cited by 21 publications

(22 citation statements)

References 28 publications

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“…When we analyzed PSA values and the histopathological features (perineural invasion, surgical margin positivity, extraprostatic spread, seminal vesicle invasion, and Gleason score) with high NLR, there was a relationship between high NLR and Gleason score. Contrary to our cohort; Maeda and colleagues found no association between NLR and Gleason score and other histopathological features in their study covering 73 patients (20). PLR independently predicts poor prognosis in patients with conditions including gastric cancer, pancreatic cancer, ovarian cancer, colorectal cancer, non-small cell lung cancer, hepatocellular carcinoma, renal cell cancer, and esophageal cancer (16).…”

Section: Discussioncontrasting

confidence: 72%

Can Neutrophil/Lymphocyte and Platelet/Lymphocyte Rates Predict Bone Metastasis in Prostate Cancer Patients?

Ceylan¹,

Tatlıdil²,

Şen³

et al. 2019

jus

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Bone metastasis is common in advanced prostate cancer (PCa). Recently, there has been a growing interest in the potential role of inflammatory markers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and neutrophil-to-monocyte ratio (NMR), in predicting advanced disease in patients with solid tumors. In the current study, we aimed to assess the relationship of bone metastasis detected on bone scintigraphy (BS) with NLR, PLR, and NMR in patients with Pca. Materials and Methods: The study group included 85 PCa patients. Patient characteristics, prostate-specific antigen (PSA) values, Gleason score, histopathological features, presence of metastatic focus on BS and complete blood count values were retrospectively evaluated. The relationship of the presence of bone metastasis on BS with clinicopathological features such as PSA, Gleason score, histopathological findings and NLR, PLR and NMR values were investigated. Results: Median NLR, PLR and NMR were 2.90, 125.69 and 8.38, respectively. Thirty-six patients had metastatic disease on BS. Our findings showed a statistically significant relationship between high NLR value and the presence of bone metastasis (p=0.018) and high Gleason score (p=0.034). However, no significant statistical relationship was found between clinicopathological features and PLR and NMR values (p>0.05). Conclusion: Despite the limited number of patients, a significant relationship between high NLR and metastatic bone disease was found. While high NLR has been generally considered an independent risk factor for poor PCa prognosis, we assume that larger scale studies are warranted to assess its value as a prognostic indicator in PCa patients.

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Section: Discussioncontrasting

confidence: 72%

Can Neutrophil/Lymphocyte and Platelet/Lymphocyte Rates Predict Bone Metastasis in Prostate Cancer Patients?

Ceylan¹,

Tatlıdil²,

Şen³

et al. 2019

jus

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“…It has been proposed that the NLR can be used to estimate the magnitude of systemic inflammation in cancer patients [ 13 – 16 ]. Several retrospective studies have evaluated the baseline NLR as a prognostic factor in prostate cancer [ 17 – 20 ]. The NLR can easily be calculated from the CBC data without much labor or cost.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio Predicts Prognosis in Castration-Resistant Prostate Cancer Patients Who Received Cabazitaxel Chemotherapy

Uemura

Kawahara

Yamashita

et al. 2017

BioMed Research International

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Introduction and Objectives An elevated neutrophil-to-lymphocyte ratio (NLR) has been suggested to be associated with a poor prognosis in several cancers. We evaluated the utility of an elevated NLR as a biomarker to predict the prognosis of metastatic castration-resistant prostate cancer (mCRPC) patients treated with cabazitaxel (CBZ). Methods We analyzed 47 patients who received CBZ chemotherapy for mCRPC in our institutions. The NLR was calculated using the neutrophil and lymphocyte counts before CBZ chemotherapy. We determined the NLR cut-off value based on the sensitivity and specificity levels derived from area under the receiver operator characteristic curves for death. A multivariate analysis was performed to investigate the association between the NLR and the prognosis. Results The median overall survival (OS) after CBZ was 10.0 months (range: 6.3–13.2). The median OS was shorter in patients with a high NLR (≥3.83) than in those with a low NLR (<3.83) (5.8 versus 13.2 months, p = 0.018). In the multivariate analysis, the NLR, patient age, and lymph node (LN) metastasis were independent predictors of the OS (hazard ratio 3.01, p = 0.030; hazard ratio 3.10, p = 0.029; hazard ratio 12.38, p = 0.001, resp.). Conclusions NLR might be a useful prognostic biomarker in mCRPC patients treated with CBZ.

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“…Notably, leukocytes were demonstrated to accumulate in the lung prior to infiltration of the tissue by cancer cells (in a pre-metastatic lung), and their numbers increased during metastatic progression (in a metastatic lung) ( 10 ). Increasingly, evidence has demonstrated that a systemic inflammatory response has a prognostic value in various cancers ( 11 – 14 ). Amongst the convenient and available markers, a high ratio of neutrophils to lymphocytes (NLR) and platelets to lymphocytes (PLR), which are calculated from the complete blood count with differential ( 15 ), also have been combined to form inflammation-based prognostic scores to predict cancer survival ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

The prognostic value of neutrophil to lymphocyte and platelet to lymphocyte ratios for patients with lung cancer

Wang

Liang

et al. 2017

Oncol Lett

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As the leading cause of cancer-associated mortality globally among males in 2012, lung cancer is a disease of particular concern. Previously, the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) were revealed to be prognostic factors for various types of cancer, including lung cancer. In the present study, a retrospective review was conducted with patients who were diagnosed with lung cancer between January 1, 2000 and December 31, 2005 in the Fourth Hospital of Hebei Medical University. A total of 695 patients were included, and the optimal cutoffs of the NLR and the PLR were 6.0 and 248.0, respectively. There were statistically significant associations between tumor-node-metastasis (TNM) stage, surgery, metastasis incidence and NLR (P<0.001). The associations between TNM stage, surgery incidence and PLR were also revealed to be statistically significant (P<0.001). Patients in the low NLR group demonstrated longer overall survival (OS) than patients in the high NLR group (819.57 days vs. 629.86 days, P=0.041). The NLR at diagnosis was demonstrated to be an independent prognostic factor for OS. Thus, the NLR may be a promising approach for predicting the prognosis of patients with lung cancer.

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Lack of an Association between Neutrophil-to-Lymphocyte Ratio and PSA Failure of Prostate Cancer Patients Who Underwent Radical Prostatectomy

Cited by 21 publications

References 28 publications

Can Neutrophil/Lymphocyte and Platelet/Lymphocyte Rates Predict Bone Metastasis in Prostate Cancer Patients?

Can Neutrophil/Lymphocyte and Platelet/Lymphocyte Rates Predict Bone Metastasis in Prostate Cancer Patients?

Neutrophil-to-Lymphocyte Ratio Predicts Prognosis in Castration-Resistant Prostate Cancer Patients Who Received Cabazitaxel Chemotherapy

The prognostic value of neutrophil to lymphocyte and platelet to lymphocyte ratios for patients with lung cancer

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