Lack of an Association of a Single Nucleotide Polymorphism in the Promoter of the Matrix Metalloproteinase-1 Gene in Czech Women with Pregnancy-Induced Hypertension

Jurajda, Michal; Kaňková, Kateřina; Mužı́k, Jan; Unzeitig, Vít; Drábková, Marie; IzakovičováHollá, Lydie; Vácha, Jiří

doi:10.1159/000052956

Cited by 13 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, simultaneous carriage of 1G/1G polymorphisms by mother and fetus appears to more than double the risk of occurrence of preeclampsia (OR = 2.39, 95% CI 1.01–5.65). Our findings do not confirm those of Jurajda et al [ 33 ], who did not find any significant association between 1G/2G MMP1 gene polymorphisms and pregnancy hypertension in a Caucasian population; however, the study of Jurajda et al included women with recognized preeclampsia, eclampsia, and chronic hypertension, while patients with chronic hypertension were excluded in the present study.…”

Section: Discussioncontrasting

confidence: 99%

Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia

et al. 2018

View full text Add to dashboard Cite

Background Metalloproteinases (MMPs) play a pivotal role during the process of trophoblast invasion and placentation. The appearance of five functional single-nucleotide polymorphisms (SNP) in the genes of the metalloproteinases most commonly implicated in the implantation process may influence the development of preeclampsia. Methods Blood samples were collected from 86 mothers and 86 children after preeclampsia and 85 mothers and 85 children with uncomplicated pregnancies. The distribution of genotypes for −1607 1G/2G MMP1, −735 C/T MMP2, −1306 C/T MMP2, −1171 5A/6A MMP3, and −1562C/T MMP9 polymorphisms was determined by RFLP-PCR. Results The occurrence of 1G/1G MMP1 or 5A/5A MMP3 genotype in the mother or 1G/1G MMP1 or 5A/6A MMP3 genotype in the child is associated with preeclampsia development. Moreover, simultaneous maternal and fetal 1G/1G homozygosity increases the risk of preeclampsia development 2.39-fold and the set of maternal 5A/5A and fetal 5A/6A MMP3 genotypes by over 4.5 times. No association between the carriage of studied MMP2 or MMP9 polymorphisms and the predisposition to preeclampsia was found. Conclusion The maternal 1G/1G MMP1 and 5A/5A MMP3 and fetal 1G/1G MMP1 and 5A/6A MMP3 gene polymorphisms may be strong genetic markers of preeclampsia, occurring either individually or together.

show abstract

Section: Discussioncontrasting

confidence: 99%

Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Therefore, the spiral arteries could not adapt to the physiological changes in pregnancy, which caused a reduction of the blood flow of the placenta, reduction of the oxygen content of the villi, villous ischemia and anoxia. The conclusion of the present study is consistent with the findings of Jurajda et al ( 16 ). All these factors may be associated with hypertension disorder in pregnancy.…”

Section: Discussionsupporting

confidence: 94%

Decreased expression of matrix metalloproteinase-1 in the maternal umbilical serum, trophoblasts and decidua leads to preeclampsia

Deng

Ling

Liu

et al. 2015

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

The aim of the present study was to explore the levels of matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the maternal umbilical serum, placenta and decidua of patients with preeclampsia compared with those in normotensive pregnant females. A total of 73 pregnant females were recruited as the test subjects, including 43 inpatients with hypertensive disorders in pregnancy and 30 normal pregnant females as the control. The 43 inpatients with hypertensive disorders in pregnancy included 18 patients with gestational hypertension, nine with mild preeclampsia and 16 with severe preeclampsia. MMP-1 and TIMP-1 ELISA kits were used to determine the MMP-1 and TIMP-1 levels in the umbilical serum of the parturient following delivery. MMP-1 and TIMP-1 expressed in the placenta and decidua of the parturient following delivery were evaluated using immunohistochemistry. MMP-1 and TIMP-1 were mainly located in cytotrophoblasts and syncytiotrophoblasts in the placenta and decidua. The levels of MMP-1 in the umbilical serum of the normal, gestational hypertension, mild preeclampsia and severe preeclampsia groups were 294.33±11.53, 247.78±20.32, 177.67±12.63 and 124.68±15.41 pg/ml, respectively, and there were significant differences between each two groups (P<0.05). The positive expression rate of MMP-1 in the placenta and decidua of patients with hypertensive disorders in pregnancy was lower than that of the controls (P<0.01 and P<0.01, respectively). However, no significant difference was identified between each two groups with regard to the levels of TIMP-1 in the umbilical cord and the positive rates in the placenta and decidua (P>0.05). Reduced MMP-1 levels in the umbilical serum, placenta and decidua were observed in women who developed preeclampsia.

show abstract

“…Although studies of over 50 candidate genes have been reported, eight genes account for 70 % of published research into candidate genes for pre-eclampsia. These have been suggested by the features of established disease: genes encoding elements of the renin-angiotensin system, which regulates blood pressure (angiotensinogen, [72] angiotensin-converting enzyme and angiotensin receptors); inherited thrombophilias (coagulation factor V Leiden variant, prothrombin and methylene tetrahydrofolate reductase); the NOS3 gene regulating the synthesis of the vasorelaxant eNOS (endothelial nitric oxide synthase); and the gene encoding the cytokine TNF (tumour necrosis factor) α.…”

Section: Candidate Gene Studiesmentioning

confidence: 99%

Searching for genetic clues to the causes of pre-eclampsia

2006

View full text Add to dashboard Cite

Pre-eclampsia and its related syndromes are significant causes of maternal and fetal death, but much remains unclear about the underlying disease mechanisms. Epidemiological research has consistently demonstrated a familial predisposition to pre-eclampsia, which has encouraged genetic research in this area. The goal is the discovery of susceptibility genes which will inform understanding of the pathophysiology of pre-eclampsia, and may prove to be targets for therapeutic or preventative strategies. This review examines the application of molecular technologies to the search for genetic clues in pre-eclampsia and emphasizes the importance of integrative approaches. The results of recent genome-wide linkage studies have been particularly encouraging, identifying a number of loci which merit closer examination. Candidate gene studies have proved less fruitful, generating conflicting and inconclusive results. Possible explanations and remedies for this deficiency are discussed with a view to stimulating closer collaboration between researchers in this field.

show abstract

Lack of an Association of a Single Nucleotide Polymorphism in the Promoter of the Matrix Metalloproteinase-1 Gene in Czech Women with Pregnancy-Induced Hypertension

Cited by 13 publications

References 18 publications

Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia

Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia

Decreased expression of matrix metalloproteinase-1 in the maternal umbilical serum, trophoblasts and decidua leads to preeclampsia

Searching for genetic clues to the causes of pre-eclampsia

Contact Info

Product

Resources

About