Lack of an Effect of Saline Loading on Glycerol-Induced Acute Renal Failure

Abstract

To determine whether saline loading actually protects against acute renal failure, both Gn and BUN were measured in rats drinking either tap water or 1% saline for 1–3 months. At 24 and 48 h after an injection of 10 ml/kg i.m. of 50% glycerol in water, Gn was equally reduced in saline-drinking and water-drinking rats as compared to uninjected rats. The daily intraperitoneal injection of saline for 1–3 months also was not protective. At 48 hours after glycerol injection, the BUN concentration in saline-drinking rats was significantly lower than in water-drinking rats. This was probably due to the greater renal urea clearance in these animals. We conclude from these findings that saline loading does not protect against glycerol-induced acute renal failure in the rat although it affects the C_urea and BUN concentration.

Hydrogen peroxide-induced renal injury. A protective role for pyruvate in vitro and in vivo.

“…0 animals pretreated with equimolar saline. We performed an additional control with hypertonic saline since some but not all studies have suggested that hypertonic saline may be beneficial in this model of acute renal injury (31,32). Basal GFR in the three groups was not different.…”

Protection Against Acute Renal Failure by Prior Acute Renal Failure: Differences between Myohemoglobinuric and Ischemic Models

“…In the case of acute renal failure, or acute tubular necrosis, two maneuvers have been espe cially effective in reducing the frequency and severity of the acute azotemia: the first is the protection conferred by the ingestion of sodium chloride [1][2][3][4], the second is protection conferred by prior acute renal failure [5][6][7][8][9], Recent studies indicate that the administration of sodium chloride protects against many forms of renal insult in cluding injury induced by nephrotoxins and myohemoglobinuria [10]. Cross-protection also exists between my ohemoglobinuric (induced by glycerol injection) and nephrotoxic acute renal failure, independently of which agent is administered first or second [8], Although is chemia-induced renal injury is a well-described model of acute renal failure [11,12], protection conferred by a prior, unrelated type of renal injury against a subsequent, is chemia-induced acute renal failure has not been studied.…”