Lack of association between ADRA2B -4825 gene insertion/deletion polymorphism and migraine in Chinese Han population

Ni, Jielei; Jia, Shasha; Liu, Min; Chen, Shougong; Jiang, Yuting; Dong, Wanli; Gao, Yuzhen

doi:10.1007/s12264-010-0301-0

Cited by 4 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From analysing the KEGG pathway, we found that Lc–Pl couplet medicines mainly treat migraines via the neural activity ligand–receptor interaction pathway, the calcium signalling pathway, the cGMP-PKG signalling pathway, pathways in cancer and the cAMP signalling pathway. Approximately one-third of the identified targets are involved in the neural activity ligand–receptor interaction pathway, including adrenergic receptors [ADRA2B ( Ni et al, 2010 ) and ADRB2 ( Bayerer et al, 2010 )], dopamine receptors [DRD1 ( Shepherd et al, 2010 )], 5-HT receptors [HTR2A ( Nyholt et al, 1996 ; Yücel et al, 2016 )], opioid receptors [OPRM1 (Wu)], GABA receptors [GABRA1 ( Milena et al, 2020 ) and GABRA3 ( Plummer et al, 2011 )], glutamate receptors [GRIA2 ( Gasparini et al, 2014 )] and capsaicin receptors [TRPV1 ( Meents et al, 2010 )]. These receptors play an important role in the processes involved in migraine attacks.…”

Section: Discussionmentioning

confidence: 99%

Exploring the pharmacological action mechanism of Ligusticum Chuanxiong-Piper Longum couplet medicines on the treatment of migraine based on network pharmacology

Li¹,

Guo²,

Lu³

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Objective: To study the mechanisms of the Ligusticum chuanxiong Hort.–Piper longum L. herbal pair (LPHP) in the treatment of migraine using network pharmacology.Methods: The active constituents of LPHP and their targets were searched for and screened using the Chinese Medicine System Pharmacology Database. Genes related to migraine were searched on GeneCards, Online Mendelian Inheritance in Man and other databases. Cytoscape was used to construct and combine active component–target and disease–target networks. The core target was screened by network topology analysis, and the Metascape database was used for gene ontology analysis of key targets and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis to explore the molecular mechanisms in the treatment of migraine.Results: A total of 28 active constituents of LPHP were obtained through database screening and literature review, and 60 cross-linking targets were obtained. The target sites were analysed using a protein–protein interaction network to obtain six target proteins with a greater degree of relevance. These were identified as the main targets for the treatment of hypertension, and these key targets were found to be associated with 20 signalling pathways, including neuroactive ligand–receptor interaction, the calcium signalling pathway, the cGMP–PKG signalling pathway, pathways in cancer and the cyclic adenosine 3′,5′-cyclic monophosphate (cAMP) signalling pathway.Conclusion: This study reveals the molecular mechanism of LPHP in the treatment of migraine from the perspective of network pharmacology and provides a basis for further research and molecular mechanism research.

show abstract

Section: Discussionmentioning

confidence: 99%

Exploring the pharmacological action mechanism of Ligusticum Chuanxiong-Piper Longum couplet medicines on the treatment of migraine based on network pharmacology

Li¹,

Guo²,

Lu³

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…The 12Glu9 or I/D polymorphism is linked to the autonomic dysfunction and increased sympathetic nervous system activity (Papanas et al, 2007). These characteristics have been associated with adverse metabolic and vascular effects, including reduced basal metabolic rate (Heinonen et al, 1999), obesity (Siitonen et al, 2004), and earlier onset of diabetes (Papazoglou et al, 2006), acute coronary ischemia (Snapir et al, 2001), T2DM with neuropathy (Papanas et al, 2007), sudden cardiac death (Laukkanen et al, 2009), spontaneous abortions (Galazios et al, 2011), migraine (Ni et al, 2010), glucose 6 phosphate dehydrogenase (Alharbi et al, 2013), suicide (Fukutake et al, 2008), and hypertension with and without T2DM (Vasudevan et al, 2008). Several studies of subjects from different ethnic backgrounds have reported a positive or negative association between the ADRA2B gene variants in different diseases.…”

Section: Discussionmentioning

confidence: 99%

Insertion and deletion polymorphism in the alpha-2B adrenoceptor gene in pregnant women ripens gestational diabetes mellitus

Al-Hakeem

Abotalib

Alharbi

et al. 2016

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

There are no earlier studies that reported the association of the 12Glu9 polymorphism in the alpha-2B adrenoceptor (ADRA2B) gene with gestational diabetes mellitus (GDM). We examined the potential association between the ADRA2B gene insertion/deletion (I/D) polymorphism in the Saudi population with GDM. Pregnant women with GDM have been reported to exhibit the same susceptibility as that observed in type 2 diabetes mellitus (T2DM). We have selected I/D polymorphism of the ADRA2B gene located in chromosome 2q11.1 that has been extensively related to T2DM and cardiovascular diseases. This case-control study was conducted with 200 GDM and 300 non-GDM pregnant women. Genotyping of I/D polymorphism was performed by conventional PCR method. Biochemical analyses were found to be significantly different between GDM and non-GDM subjects (p < 0.05). Genotype (ID + DD vs II, p = 0.0002) and allele (D vs I, p = 0.0002) frequencies of the 12Glu9 polymorphism were found to be statistically significant. However, a significant difference was found between allele and genotypes of I/D polymorphism of the ADRA2B gene or the clinical characteristics of the subjects. Our results obtained in this study indicate the ADRA2B gene in the Saudi women was associated with the development of GDM.

show abstract

“…Several genetic studies exploring polymorphisms at 3 genetic loci have been performed in the First Affiliated Hospital of Soochow University. The loci are: the tumor necrosis factor receptor superfamily member 1b gene (the TNFRSF1B gene), the inducible NO synthase gene (the NOS2 gene), and the promoter region of the α 2B ‐adrenergic receptor gene (the ADRA2B gene) . Polymorphisms in the promoter regions of TNFRSF1B and NOS2 were associated with migraine in the Chinese population, but no association was found between an ADRA2B‐4825 gene insertion/deletion polymorphism and migraine at either the allelic or genotypic level.…”

Section: Developments In Headache Research In Chinamentioning

confidence: 99%

Headache Care in China

Zhang

Zhou

et al. 2014

Headache

View full text Add to dashboard Cite

Headache disorders are problematic worldwide. China is no different. A population-based door-to-door survey revealed that the 1-year prevalence of primary headache disorders in China was 23.8%, constituting a major societal burden. Many headache centers and clinics have been established in China, and headache disorders (and associated stress) are receiving an increased level of expert attention. This review summarizes the outcomes of the epidemiological survey and the progress of clinical and basic research in China, describes the present situation in terms of headache diagnosis and treatment, and discusses the future of headache care in China.

show abstract

Lack of association between ADRA2B -4825 gene insertion/deletion polymorphism and migraine in Chinese Han population

Abstract: These findings do not support a functional significance of ADRA2B indel polymorphism at position -4825 relative to the start codon in the far upstream region of the promoter in the present migraine subjects.

Cited by 4 publications

References 17 publications

Exploring the pharmacological action mechanism of Ligusticum Chuanxiong-Piper Longum couplet medicines on the treatment of migraine based on network pharmacology

Exploring the pharmacological action mechanism of Ligusticum Chuanxiong-Piper Longum couplet medicines on the treatment of migraine based on network pharmacology

Insertion and deletion polymorphism in the alpha-2B adrenoceptor gene in pregnant women ripens gestational diabetes mellitus

Headache Care in China

Contact Info

Product

Resources

About