Lack of association between aortic sclerosis and left ventricular hypertrophy in elderly subjects

Nightingale, Angus K; Sverdlov, Aaron L.; Rajendran, S; Mishra, Kumaril; Heresztyn, Tamila; Ngo, Doan T; Horowitz, John D.

doi:10.1016/j.ijcard.2010.02.024

Cited by 8 publications

(4 citation statements)

References 29 publications

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“…Reactive oxygen species (ROS) are free radicals found in all vascular cells which can inactivate NO and decrease NO bioavailability in blood vessels and lead to the injury of endothelial functions. It has also been reported that the reduced formation of NO or impairment of nitric oxide effect may be associated with aortic sclerosis [45]. Studies also suggest that the imbalance between ROS and NO levels, rather than the individual levels, can be a major cause of endothelial dysfunction in numerous cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of Astragalus polysaccharides against endothelial dysfunction in hypertrophic rats induced by isoproterenol

Han

Tang

Lü

et al. 2016

International Immunopharmacology

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Section: Discussionmentioning

confidence: 99%

Protective effects of Astragalus polysaccharides against endothelial dysfunction in hypertrophic rats induced by isoproterenol

Han

Tang

Lü

et al. 2016

International Immunopharmacology

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“…Endothelial NO produced by eNOS may inhibit apoptosis, and is regarded as a survival factor for endothelial cells (35). It has been reported that the reduced formation of NO or impairment of NO effects may be associated with aortic sclerosis (36). Additional studies have indicated that reduced NO bioavailability enhances atherogenesis in animal models (8), and contributes to endothelial dysfunction (37).…”

Section: Discussionmentioning

confidence: 99%

Astragalus polysaccharide ameliorates H2O2-induced human umbilical vein endothelial cell injury

Han

Tang

Lü

et al. 2017

Molecular Medicine Reports

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Endothelial dysfunction caused by reactive oxygen species (ROS) has been implicated in numerous cardiovascular diseases. Astragalus polysaccharide (APS), an important bioactive component extracted from the Chinese herb Astragalus membranaceus, has been widely used for the treatment of cardiovascular disease. The present study aimed to investigate the effects of APS on hydrogen peroxide (H2O2)-induced human umbilical vein endothelial cell (HUVEC) injury. Following treatment with 400 µM H2O2 for 24 h, cell viability was decreased and apoptosis was increased. However, pretreatment with APS for 1 h significantly attenuated H2O2-induced injury in HUVECs. In addition, APS decreased intracellular ROS levels, increased the protein expression of endothelial nitric oxide synthase and copper-zinc superoxide dismutase, elevated intracellular cyclic guanosine monophosphate (an activity marker for nitric oxide) levels and restored the mitochondrial membrane potential, compared with cells treated with H2O2 only. In conclusion, the results of the present study suggested that APS may protect HUVECs from injury induced by H2O2 via increasing the cell antioxidant capacity and nitric oxide (NO) bioavailability, which may contribute to the improvement of the imbalance between ROS and NO levels.

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“…Others have used IB for the quantitative detection of aortic valve calcifications in vitamin D treated rabbits, which could be delayed with ramipril [24,25]. Preliminary clinical studies have demonstrated that higher backscatter scores are seen in sclerotic compared to non-sclerotic aortic valves, with a further increase in stenotic valves [26,27]. Backscatter scores of the aortic valve directly correlated with subjective scoring and with transvalvular pressure gradients in patients [13].…”

Section: Discussionmentioning

confidence: 99%

Echocardiographic integrated backscatter for detecting progression and regression of aortic valve calcifications in rats

Roosens

Bala

Gillis

et al. 2013

Cardiovasc Ultrasound

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BackgroundCalcification is an independent predictor of mortality in calcific aortic valve disease (CAVD). The aim of this study was to evaluate the use of non-invasive, non-ionizing echocardiographic calibrated integrated backscatter (cIB) for monitoring progression and subsequent regression of aortic valvular calcifications in a rat model of reversible renal failure with CAVD, compared to histology.Methods28 male Wistar rats were prospectively followed during 21 weeks. Group 1 (N=14) was fed with a 0.5% adenine diet for 9 weeks to induce renal failure and CAVD. Group 2 (N=14) received a standard diet. At week 9, six animals of each group were killed. The remaining animals of group 1 (N=8) and group 2 (N=8) were kept on a standard diet for an additional 12 weeks. cIB of the aortic valve was calculated at baseline, 9 and 21 weeks, followed by measurement of the calcified area (Ca Area) on histology.ResultsAt week 9, cIB values and Ca Area of the aortic valve were significantly increased in the adenine-fed rats compared to baseline and controls. After 12 weeks of adenine diet cessation, cIB values and Ca Area of group 1 decreased compared to week 9, while there was no longer a significant difference compared to age-matched controls of group 2.ConclusionscIB is a non-invasive tool allowing quantitative monitoring of CAVD progression and regression in a rat model of reversible renal failure, as validated by comparison with histology. This technique might become useful for assessing CAVD during targeted therapy.

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Lack of association between aortic sclerosis and left ventricular hypertrophy in elderly subjects

Cited by 8 publications

References 29 publications

Protective effects of Astragalus polysaccharides against endothelial dysfunction in hypertrophic rats induced by isoproterenol

Protective effects of Astragalus polysaccharides against endothelial dysfunction in hypertrophic rats induced by isoproterenol

Astragalus polysaccharide ameliorates H2O2-induced human umbilical vein endothelial cell injury

Echocardiographic integrated backscatter for detecting progression and regression of aortic valve calcifications in rats

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