Lack of association between atopy and RsaI polymorphism within intron 2 of the PcεRI‐β gene in a Spanish population sample

Castro, Jesús; Orriols, Juan José Tellería; Blanco‐Quirós, Alfredo; Linares, Pablo M.; Andión, R

doi:10.1111/j.1398-9995.1998.tb03819.x

Cited by 9 publications

(6 citation statements)

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“…Earlier studies carried out in various populations have shown association of intron 2, 3′‐UTR and (CA) n repeat polymorphisms with atopic childhood asthma, adulthood asthma, and physician‐diagnosed asthma (12, 15, 16). However, studies conducted in similar or different ethnic populations obtained different results (22–24). On the other hand, a study carried out in Chinese population supports our results on the intron 2 polymorphism (32).…”

Section: Discussionmentioning

confidence: 99%

“…Using four of the SNPs within the gene, haplotypes were constructed which were found to be associated with skin prick test index (SPTI)/RASTI (5). However, the results obtained from various genetic and functional studies for this and other loci have been found to be inconsistent in various populations (3,(22)(23)(24). Thus, the genetic association studies carried out in ethnically diverse populations would therefore, be crucial for understanding the role of FceRIb in asthma pathogenesis.…”

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confidence: 99%

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A_16_C haplotype in the FcεRIβ gene confers a higher risk for atopic asthma in the Indian population

et al. 2004

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We conducted a case-control study aimed at identifying polymorphisms and haplotypes in the FcepsilonRIbeta gene associated with asthma and its associated phenotypes such as serum IgE levels. A G/A polymorphism in intron 2, a (CA)n repeat polymorphism in intron 5, and a C/T polymorphism in 3'-UTR, encompassing a length of 8.74 Kb, were genotyped, and haplotypes were generated for unrelated patients and healthy volunteers in two independent cohorts. A significant association was observed at the level of alleles and genotypes studied with asthma independently in the two cohorts (p < 0.05). A change in CC_AA genotype combination to a non-CC_AA genotype was associated with reduced risk for asthma. Interestingly, a three-locus haplotype, A_16_C, was found to be significantly associated with asthma (p = 10(-5) in cohort A and p = 0.004 in cohort B). On the other hand, the haplotype G_18_T was found to be negatively associated with asthma (p = 0.007 in cohort A and p = 0.0004 in cohort B). This is the first study identifying a haplotype A_16_C that predisposes individuals to asthma in the Indian population.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

A_16_C haplotype in the FcεRIβ gene confers a higher risk for atopic asthma in the Indian population

et al. 2004

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“…However, recently, Castro et al. (48) described a lack of association between atopy and RsaI polymorphism within intron 2 of the FcɛRI‐β gene in a Spanish population. Like our results they found no differences in the genotypic frequency distribution of atopic and nonatopic populations, however, in contrast with our work no other allergic traits were studied to determine possible associations (total IgE, RAST, specific IgE).…”

Section: Genetic Restriction Of Olive Pollen Responsementioning

confidence: 99%

Update in the understanding of genetic predisposition to olive pollen sensitization

Cárdaba

Cortegano

Florido

et al. 2002

Allergy

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“…It is possible that mutations in genes that code for the IgE receptor may be responsible for the development of early hypersensitivity reactions in atopic persons by increasing the production of IL4 and activating inflammatory cells (Rabe et al, 2011). The β-chain of FcεRI stabilizes the receptor's surface expression and acts as an amplifying element (A allele is represented by the letter B and C allele by the letter A in the manuscript, as defined in the literature) (Castro et al, 1998).…”

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confidence: 99%

Association of High-Affinity FcεRI-β intron 2 for IgE Gene Polymorphism and Atopic Diseases in an Algerian Population

Dahmani¹,

Salem²,

Chakir³

et al. 2017

OnLine Journal of Biological Sciences

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Atopy is characterized by the production of a high level of IgE in response to common allergens. We examined the RsaI-in2 polymorphism of the FcεRI-β gene and its association with atopic asthma and comorbidity. The study population included 77 atopic asthmatics and 77 non-atopic, nonallergic and non-asthmatic controls. Atopic asthma was confirmed by the skin prick test and by IgE and interleukin IL-4 levels. RsaI-in2 polymorphism was determined by RFLP-PCR using the RsaI enzyme. A significant correlation was found between genotype BB and sensitization to house dust mites in the asthmatic subjects (p = 0.000). Results also reveal significant allele sharing in the subjects affected by eczema (p = 0.000) and allergic rhinitis (p = 0.01) during childhood. Furthermore, the subjects with heterozygous AB and homozygous BB genotypes displayed significant IgE levels > 1000 UI mL −1 . IL-4 levels were also > 1000 pmol/ml for RsaI-in2 polymorphism genotype BB. Our findings show a strong association between genotype BB and the incidence of eczema and allergic rhinitis in childhood as well as increased IgE and IL-4 levels.

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Lack of association between atopy and RsaI polymorphism within intron 2 of the PcεRI‐β gene in a Spanish population sample

Abstract: We did not find RasI polymorphisms associated with atopic disease. The genetic findings in atopy and asthma may be very different according to ethnic and local characteristics, and they must be carefully verified in different population samples.

Cited by 9 publications

References 9 publications

A_16_C haplotype in the FcεRIβ gene confers a higher risk for atopic asthma in the Indian population

A_16_C haplotype in the FcεRIβ gene confers a higher risk for atopic asthma in the Indian population

Update in the understanding of genetic predisposition to olive pollen sensitization

Association of High-Affinity FcεRI-β intron 2 for IgE Gene Polymorphism and Atopic Diseases in an Algerian Population

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