Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and aggressive behavior in schizophrenia

Guan, Xuan; Dong, Zaiquan; Tian, Yuanyuan; Wu, Lina; Gu, Yan; Hu, Zeqing; Zhou, Xiao

doi:10.1016/j.psychres.2013.10.017

Cited by 9 publications

(4 citation statements)

References 14 publications

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“…Analysing the MOAS subscales authors found that overt physical aggression mainly contributed to this result. These findings are in contrast to studies conducted in Chinese and Korean patients where no association was found between Val66Met polymorphism and aggressive behaviour of patients with schizophrenia [50,51].…”

Section: Brain-derived Neurotrophic Factor (Bdnf)contrasting

confidence: 99%

Genetic Polymorphisms of the Dopamine and Serotonin Systems in Schizophrenia in Relation to Violence and Aggression

Peitl

Ravlić

Zatezalo

2020

Arch. Psychiatry Res.

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Schizophrenia is a chronic disorder that ultimately leads to a decline in cognitive, social and emotional functioning. Although the aetiology of the disorder is still unknown, it is most likely multifactorial, with equal importance of environmental and genetic factors. It has been hypothesized that those same factors influence aggressive symptomatology and possibly even violence in schizophrenia. The association between schizophrenia and aggressive behaviour is well documented; however, the impact of genetic alterations and gene polymorphisms on the incidence and type of violence in this group of patients has rarely been the focus of scientific research. Both violence and aggression are complex behavioural patterns that lead to difficulties in the comparability of genetic studies and limits their clinical applicability. In this review paper we systematically presented findings from studies examining the association between gene polymorphisms of the dopamine and serotonin systems and aggressive symptoms and violent behaviour in schizophrenia.

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Section: Brain-derived Neurotrophic Factor (Bdnf)contrasting

confidence: 99%

Genetic Polymorphisms of the Dopamine and Serotonin Systems in Schizophrenia in Relation to Violence and Aggression

Peitl

Ravlić

Zatezalo

2020

Arch. Psychiatry Res.

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“…При анализе структуры гена BDNF у человека был выявлен функциональный локус Val66Met (196G > A; rs6265), который приводит к снижению секреции белканейротрофина (Hong et al, 2011). В некоторых работах показано, что носители генотипа *Met/*Met характеризуются высоким уровнем агрессии (Kretschmer et al, 2014), в то время как другие исследователи такой взаимосвязи не выявили (Guan et al, 2014;Nagata et al, 2014). Кроме того, было отмечено, что модулирующий эффект генотипа *Met/*Met во многом определяется взаимодействием с такими средовыми факторами, как хронический стресс, негативный стиль родительского воспитания, жестокое обращение или сексуальное насилие в детстве, которые, в свою очередь, способствуют формированию агрессивного фенотипа (Wagner et al, 2010;Kretschmer et al, 2014;Avinun et al, 2018).…”

Section: гены системы нейротрофического фактораunclassified

Media violance and how it`s impact on audience

Nazarova¹

2021

age-info.com

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This article is devoted to the representation of violence in modern media, in particular — to the features that are inherent in such materials, and also examines the impact of violence in journalistic materials on the audience that consumes the content. The media, as an institution of mass communication, has several basic functions, which are both derived from the needs of society and based on the interests of a particular member of society. At the moment, the attention of many researchers is closely drawn to the influence of the content of various media on the audience, the formation of the perception of individual individuals. Scientists have proven that one of the things that attracts a person is violence, because the audience is interested in «bad» news, watches crime reports. But media violence is still one of the stumbling blocks in contemporary discourse. In the article, we will consider what features are inherent in materials covering cruelty in general and crimes in particular, identify the level of influence of consumed content on the formation of individual characteristics, and also analyze a number of aggressive behavior of the audience depending on the materials

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“…2019;4:e190004. https://doi.org/10.20900/jpbs.20190004 schizophrenia [143,144]. This lack of consistency is not surprising given the complexity of human aggression, reliance on peripheral BDNF measures that can be problematic [145] and focus on the Val66Met polymorphism as we are unaware of any reports of increased aggression in mutant mice engineered to mimic this polymorphism.…”

Section: Bdnf and Aggressionmentioning

confidence: 99%

Thermoregulatory Fear of Harm Mood Disorder: In Depth Exploration of a Unique Juvenile-Onset Phenotype That Provides a Parsimonious Clinical Description of Certain Youths with Highly Comorbid Treatment Refractory Psychiatric Disorders

Papolos¹,

Mattis²,

Lachman³

et al. 2019

J Psychiatry Brain Sci

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Among aggressive youths with severe mood lability who frequently fail to benefit from mood stabilizers and antipsychotics there is a discrete subtype called 'Thermoregulatory Fear of Harm Mood Disorder' (FOH). This disorder is characterized by an underlying thermoregulatory deficit, a specific prodromal sequence and a unique constellation of symptoms.The underlying problem appears to be a deficit in thermoregulation resulting in excessive heat that manifests as thermal discomfort in neutral ambient temperatures and moderate to extreme cold tolerance, and produces REM sleep-related problems and parasomnias, such as night-terrors and hypnogogic hallucinations. Clinically, FOH is associated with the advent in childhood of frequent, recurrent, vivid nightmares with themes of pursuit and abandonment. The apparent psychological sequelae of exposure to this frightening imagery is fear sensitization and auto-traumatization. A developmental sequence of fear based defensive behaviors arises and includes obsessive bedtime rituals, fear of the dark, separation anxiety, contamination fears, hypervigilance, perfectionism, misperception of neutral stimuli as threatening, as well as reactive aggression in response to limit setting and perceived threat or loss. Ketamine, chosen as a potential treatment because of its effectiveness in reducing fear sensitization and dose-dependent lowering of body temperature in preclinical studies, has been associated with sustained Journal of Psychiatry and Brain Science 2 of 43 J Psychiatry Brain Sci. 2019;4:e190004. https://doi.org/10.20900/jpbs.20190004 improvement in otherwise refractory youths. We present a detailed description of this heritable disorder, link its clinical features to a potential disturbance in brain derived neurotropic factor (BDNF) and orexin, and indicate how ketamine rapidly affects BDNF through multiple mechanisms, to produce a dramatic beneficial response in youths with this disorder.

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Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and aggressive behavior in schizophrenia

Cited by 9 publications

References 14 publications

Genetic Polymorphisms of the Dopamine and Serotonin Systems in Schizophrenia in Relation to Violence and Aggression

Genetic Polymorphisms of the Dopamine and Serotonin Systems in Schizophrenia in Relation to Violence and Aggression

Media violance and how it`s impact on audience

Thermoregulatory Fear of Harm Mood Disorder: In Depth Exploration of a Unique Juvenile-Onset Phenotype That Provides a Parsimonious Clinical Description of Certain Youths with Highly Comorbid Treatment Refractory Psychiatric Disorders

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