Lack of Association Between Helicobacter Pylori's Virulence and Increased Serum C-Reactive Protein Levels in Functional Dyspeptic Patients

Abstract

-Background -Recently, a great variety of studies aimed to investigate and even suggest Helicobacter pylori as an important key factor in gastrointestinal and non-gastrointestinal events development. The well-established relationship between bacterial virulence and increased risk for peptic ulcer or gastric carcinoma is not so clear when comparing inflammation markers alterations, such C-reactive protein, with the pathogen. Objective -The objective of this study was to evaluate the presence of H. pylori, bacterial virulence and C-reactive protein serum levels in individuals diagnosed with functional dyspepsia. Methods -Were prospectively included in this study 489 dyspeptic individuals. They fulfill Rome III clinical criteria for the diagnosis of functional dyspepsia with no organic disease at endoscopy. The bacterial infection was established by histology and urease rapid test. The levels of serum C-reactive protein were obtained by immunonefelometry and CagA status of H. pylori positive individuals was determined through an imunoenzimatic assay. Results -Prevalence rate of H. pylori was 66.3% and virulence factor CagA was detected in nearly 43% of positive samples. In addition, it has been noticed an association between Ilex paraguariensis (yerba maté) consumption and pathogen's prevalence. An important effect of bacterial infection on inflammation was only observed in gastric epithelium. Conclusion -No systemic response to the pathogen, measured through C-reactive protein levels, was observed, regardless of CagA status. Otherwise, the intake of yerba maté should be considered as a cultural factor possibly related to H. pylori's transmission. According to the recent reports, CagA positive strains can cause severe damage to the gastric epithelium, being related specially with increased levels of interleukin-8 (IL-8), gastroduodenal ulcers and gastric neoplasia occurrence (26,29,41) . In addition, this virulence factor has been associated with systemic inflammation, resulting in high serum C-reactive protein (CRP) levels and the bacteria presence being related to higher cardiovascular risks (21,37) . Some behaviors have been associated to the transmission of H. pylori. Studies have reported that several aspects can be related to incidence and prevalence rates like socioeconomic status, years of study, institutionalization practice or social habits (8,20) . In 2010, a Brazilian study has demonstrated an anti-H. pylori activity of plant extracts, like yerba maté tea (Ilex paraguariensis), but no association between bacteria prevalence and tea consumption has been previously described (6) . Andreolla HF, Bona LR, Sander GB, Mazzoleni LE, Tavares RG, Prolla JC. Lack of association between Helicobacter pylori's virulence and increased serum C-reactive protein levels in functional dyspeptic patients HEADINGS - 50Arq Gastroenterol v. 53 no. 1 -jan./mar. 2016All H. pylori's infected people present histological gastritis. Moreover, the bacteria, classified as type I carcinogen (32) , has been associated with the...

The Relationship between CRP Levels and Gastritis in Children with or without Helicobacter pylori Infection

“…This indicates that H. pylori infection is closely related to CRP values. Several previous studies have shown that the CRP value will decrease significantly in patients who have received H.pylori eradication therapy (Andreola, et al, 2016). In this study, it was reported that the mean CRP value in the H.pylori positive group was 36.78, and the mean CRP value in the H.pylori group.…”

“…However, other studies have obtained different results. In a study conducted on 489 dyspeptic patients, it was found that the CRP value was higher in the positive H.pylori group than the negative H.pylori group, but there was no significant difference (p = 0.817) (Andreola, et al, 2016). The same thing was also reported in the study in 453 patients that CRP values were significantly higher in seropositive patients than in seronegative patients (Alimohammadin, et al, 2016).…”

Differences in C-Reactive Protein (CRP) Value Before and After Eradication Therapy of Helicobacter Pilory Gastritis in Children

“…In contrast to the Brazilian study, it was stated that there was no association between CRP levels and H. pylori infection in patients with functional dyspepsia, especially those who were Cag A positive (Andreolla et al, 2016). Research in Korea stated that H. pylori seropositivity was not associated with CRP levels.…”

The Clinical Presentation, Electrocardiogram and Echocardioscopy Features in Case of Acute Coronary Syndrome without ST Elevation Patients of Different Gender with Essential Arterial Hypertension and Helicobacter Pylori Infection

“…Нelicobacter pylori (HР) -одна з найпоширеніших інфекцій, що спостерігається у близько 60,0 % загальної популяції, і частота інфікування постійно зростає. Патолоґічний вплив НР не обмежується шлунком і дванадцятипалою кишкою, а характеризується також екстраабдомінальними порушеннями, зокрема системним запаленням, яке вважається критичним компонентом атеросклерозу і чинником ризику ГКС [2,5,8].…”

“…HP провокує запальні та імунні реакції як на локальному, так і на системному рівні. Можливий зв'язок НР і ГКС пояснюється, з одного боку, системним ефектом місцевого запалення слизової оболонки ґастродуоденальної зони, а з іншого -хронічною імунозапальною відповіддю із залученням у процес віддалених структур за рахунок прямих і непрямих механізмів [5]. Прямий вплив на судинну стінку включає безпосереднє ураження ендотелію циркулюючими ендотоксинами з виникненням дисфункції, спазму гладеньких м'язів і локального запалення, тоді як непрямий зумовлений збільшенням умісту медіаторів запалення, що виявляють прокоаґулянтний і атероґенний ефект, а також можуть бути причиною синтезу перехресних антитіл [9].…”