Lack of association between I/D ACE and -675 ID 4G / 5G PAI-1 polymorphisms and predicting risk of pregnancy loss (PROPALO) in Bosnian women

Mahmutbegović, Emir; Skonieczna-Żydecka, Karolina; Valjevac, Amina; Mahmutbegović, Nevena; Pawińska-Matecka, Anna; Czerska, Ewa; Marjanović, Damir; Adler, Grażyna

doi:10.1007/978-981-10-4166-2_68

Cited by 2 publications

(9 citation statements)

References 26 publications

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“…Of the 71 included studies, 15 were rated good, 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 39 were rated fair, 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 and 17 were rated poor. 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-one studies investigated cases with preeclampsia, 22 24 34 35 36 45 47 49 54 61 67 69 70 71 72 73 74 75 86 87 92 45 studies investigated cases with pregnancy loss described as pregnancy loss, 27 29 31 39 50 51 52 59 60 64 66 68 81 90 91 miscarriage, 23 28 30 38 40 41 42 44 53 55 56 57 58 62 65 76 78 79 88 abortion, 37 43 48 63 77 83 89 fetal loss, 46 80 82 or intrauterine fetal death. 84 One study investigated cases delivering still birth, 33 one study investigated cases delivering newborns meeting the criteria for intrauterine growth restrictions, 26 and three studies investigated cases with various adverse pregnancy outcomes.…”

Section: Resultsmentioning

confidence: 99%

“…84 One study investigated cases delivering still birth, 33 one study investigated cases delivering newborns meeting the criteria for intrauterine growth restrictions, 26 and three studies investigated cases with various adverse pregnancy outcomes. 25 32 85 Sixty-eight (96%) studies were case–control studies, 22 23 24 25 26 27 28 29 30 31 33 34 35 36 37 38 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 87 88 89 90 91 92 while three were cohort studies. …”

Section: Resultsmentioning

confidence: 99%

“…The association between PAI-1 genotype and pregnancy loss was investigated in 45 studies. 23 27 28 29 30 31 37 38 39 40 41 42 43 44 46 48 50 51 52 53 55 56 57 58 59 60 62 63 64 65 66 68 76 77 78 79 80 81 82 83 84 88 89 90 91 Pregnancy loss was described as miscarriage, abortion, fetal loss, or intrauterine fetal death. The definition differed across studies according to gestational week and number of pregnancy losses.…”

Section: Resultsmentioning

confidence: 99%

“…In 44 out of 45 studies the -675 4G/5G polymorphism was examined. Among these, 23 studies (52%) found no significant associations between 4G/5G polymorphism and pregnancy loss reported as either no difference in the genotype distribution comparing cases and controls 23 31 38 40 42 43 44 46 52 56 57 58 65 77 81 83 84 88 and/or no significantly increased odds of pregnancy loss comparing either 4G/4G genotype to 4G/5G + 5G/5G (the recessive model), 28 30 52 57 80 4G/4G + 4G/5G to 5G/5G genotype (the dominant model) 42 51 53 58 88 or 4G/4G to 5G/5G. 23…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

The Role of Plasminogen Activator Inhibitor Type 1 (PAI-1) in Placenta-Mediated Pregnancy Complications: A Systematic Review

Agersnap

Nissen

Hvas

2022

Semin Thromb Hemost

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Plasminogen activator inhibitor type 1 (PAI-1) is a main inhibitor of fibrinolysis. The PAI-1 gene (SERPINE1) harbors genetic variants with the potential of modifying plasma levels of PAI-1. A delicate balance exists between the coagulation and fibrinolytic system, and changes in PAI-1 have been suggested to compromise establishment of a successful pregnancy. Therefore, this systematic review investigated the association between genetic variants and/or plasma levels of PAI-1 and placenta-mediated pregnancy complications. An extensive literature search was conducted in PubMed, Embase, and Web of Science on the 29th of April 2021. All studies underwent quality rating according to The Study Quality Assessment Tools checklist provided by National Heart, Lung and Blood Institute. A total of 71 studies were included, among which 60 studies investigated PAI-1 genotypes and 11 studies measured PAI-1 plasma levels. In 32 out of 59 studies, no association was found between the PAI-1 4G/5G polymorphism (rs1799768) and placenta-mediated pregnancy complications, which was stated as no significant difference in the genotype distribution comparing women with and without placenta-mediated pregnancy complications or no significantly increased odds of placenta-mediated pregnancy complications carrying the 4G/4G or 4G/5G genotype. Eight out of 11 studies reported significantly higher PAI-1 plasma levels in preeclamptic women than in women without preeclampsia. In conclusion, no clear evidence indicates that PAI-1 polymorphisms are associated with placenta-mediated pregnancy complications, and the possible association between high PAI-1 plasma levels and preeclampsia needs further investigations. Thus, investigation of PAI-1 genotypes and PAI-1 plasma levels does not currently seem to have a place in daily clinical practice managing placenta-mediated pregnancy complications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

The Role of Plasminogen Activator Inhibitor Type 1 (PAI-1) in Placenta-Mediated Pregnancy Complications: A Systematic Review

Agersnap

Nissen

Hvas

2022

Semin Thromb Hemost

View full text Add to dashboard Cite

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Genetic Architecture of Pregnancy Loss: Co-inheritance of Risk Factors in Bosnian Women

Adler,

Mahmutbegović

2023

Fol. Biol.

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Pregnancy-related complications (PRC) represent a serious public health and healthcare challenge. In European countries, infertility among couples varies from 5 to 24 %. The cause of PRC may include autoimmune and metabolic factors, correctness of the karyotype and variants of selected genes. The impact magnitude of genetic variants in one of PRC, pregnancy loss (PL), is still unexplored. Therefore, in this study, raw data on 12 single-nucleotide polymorphisms (SNPs) that were published separately in 2017–2019 were re-examined. We analysed the co-inheritance of 12 SNPs: rs6025 FV, rs429358 and rs7412 ApoE, rs1799752 ACE, rs1799889 PAI–1, rs1799963 PT, rs1801133 MTHFR, rs9468 and rs1800547 INV 17q21.31, rs731236 and rs1544410 VDR, and rs10421768 HAMP. Each time, the same study group of 154 women with PL, mean age 33 (± 5.4) years, and 154 mothers without PL, mean age 31.4 (± 6.7) years, with at least one live-born child, a control group, was investigated. In Bosnian women, no relationship of the co-inheritance pattern of any of the studied variants with PL was confirmed: P was in the range 0.248–1.0. In conclusion, the role of co-inheritance of heterozygotes and homozygotes or homozygotes of selected genes in PL has not been fully confirmed.

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Lack of association between I/D ACE and -675 ID 4G / 5G PAI-1 polymorphisms and predicting risk of pregnancy loss (PROPALO) in Bosnian women

Cited by 2 publications

References 26 publications

The Role of Plasminogen Activator Inhibitor Type 1 (PAI-1) in Placenta-Mediated Pregnancy Complications: A Systematic Review

The Role of Plasminogen Activator Inhibitor Type 1 (PAI-1) in Placenta-Mediated Pregnancy Complications: A Systematic Review

Genetic Architecture of Pregnancy Loss: Co-inheritance of Risk Factors in Bosnian Women

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