Lack of Association Between <i>PDCD-1</i> Polymorphisms and Colorectal Cancer Risk: A Case-Control Study

Lin, Jing; Chen, Hanshen; Huang, Yu-Fang; Tang, Weifeng; Zhang, Sheng; Chen, Yu

doi:10.1080/08820139.2022.2069504

Cited by 3 publications

(3 citation statements)

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“…However, in a recent study reported by Fathi, et al [ 54 ], no association between PD-1.6 and basal cell carcinoma (BCC) was found. Similarly, in two other separate case-control studies, no associations were detected between PD-1.6 polymorphism and the risk of developing CRC in subjects from Heilongjiang Province in Northeast China [ 2 ] and Eastern China [ 36 ]. However, associations between PD-1.6 polymorphisms and several infectious and autoimmune diseases have been reported in many studies [ 20 , 27 , 29 , 30 , 32 , 55 , 56 ].…”

Section: Discussionmentioning

confidence: 93%

“…For PD-1.5 and PD-1.9 , controversial results have been reported for their association with cancer diseases. Two separate studies reported no association between PD-1.9 and CRC in two populations in China, conducted by Ge et al [ 2 ] and Lin et al [ 36 ]. However, an association between PD-1.5 and an increased susceptibility to colon cancer and rectal cancer was reported earlier by Mojtahedi et al [ 37 ] in an Iranian population.…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have investigated the role and correlation between SNPs in the PD-1 gene and CRC pathogenesis, and the results have been controversial [ 2 , 36 , 37 ]. To the best of our knowledge, no studies have reported on the association between PD-1 gene polymorphism and immune or cancerous diseases across the countries of the Arabian Peninsula.…”

Section: Introductionmentioning

confidence: 99%

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Rs10204525 Polymorphism of the Programmed Death (PD-1) Gene Is Associated with Increased Risk in a Saudi Arabian Population with Colorectal Cancer

Alharbi

Vaali-Mohammed²,

Alomar³

et al. 2022

Medicina

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Checkpoint programmed death-1 (PD-1) has been identified as an immunosuppressive molecule implicated in the immune evasion of transformed cells. It is highly expressed in tumor cells in order to evade host immunosurveillance. In this study, we aimed to assess the association between single nucleotide polymorphisms (SNP) of PD-1 and the risk of colorectal cancer (CRC) in the Saudi population. For this case-control study, the TaqMan assay method was used for genotyping three SNPs in the PD-1 gene in 100 CRC patients and 100 healthy controls. Associations were estimated using odds ratios (ORs) and 95% confidence intervals (95% CIs) for multiple inheritance models (codominant, dominant, recessive, over-dominant, and log-additive). Moreover, PD-1 gene expression levels were evaluated using quantitative real-time PCR in colon cancer tissue and adjacent colon tissues. We found that the PD-1 rs10204525 A allele was associated with an increased risk of developing CRC (OR = 2.35; p = 0.00657). In addition, the PD-1 rs10204525 AA homozygote genotype was associated with a high risk of developing CRC in the codominant (OR = 21.65; p = 0.0014), recessive (OR = 10.97; p = 0.0015), and additive (OR = 1.98; p = 0.012) models. A weak protective effect was found for the rs2227981 GG genotype (OR = 2.52; p = 0.034), and no significant association was found between the rs2227982 and CRC. Haplotype analysis showed that the rs10204525, rs2227981, rs2227982 A-A-G haplotype was associated with a significantly increased risk of CRC (OR = 6.79; p =0.031).

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