Lack of association between macrocytosis and multiple sclerosis.

Grasso, Maria Grazia; Colleluori, A.; Millefiorini, Enrico; Pozzilli, Carlo

doi:10.1136/jnnp.55.11.1096

Cited by 6 publications

(6 citation statements)

References 6 publications

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“…3 Reynolds did not find any correlation between MCV and duration of disease or age, in agreement with our results. In our study we did not find macrocytosis, instead a tendency towards the lower reference limit was found, also described by Grasso et al 28 The albumin ratio reflects the blood ¡/brain barrier and an increased ratio is indicative of damage. We found no significant correlation between the albumin ratio and CSF tHcy or CSF MMA in our MS patients.…”

Section: Discussionsupporting

confidence: 83%

Increased plasma homocysteine levels without signs of vitamin B12 deficiency in patients with multiple sclerosis assessed by blood and cerebrospinal fluid homocysteine and methylmalonic acid

Vrethem¹,

Mattsson

Hebelka

et al. 2003

Mult Scler

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The relevance of the increased mean value of plasma tHcy thus seems uncertain and does not indicate functional vitamin B12 deficiency. We can not, however, exclude the possibility of a genetically induced dysfunction of the homocysteine metabolism relevant for the development of neuroinflammation/degeneration. Our findings indicate that, regardless of a significant increase in plasma tHcy in MS patients, the MS disease is not generally associated with vitamin B12 deficiency since we did not find any other factors indicating vitamin B12 deficiency. Analysis of CSF MMA and CSF tHcy, which probably reflects the brain vitamin B12 status better than serum, are not warranted in MS. We conclude that B12 deficiency, in general, is not associated with MS.

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Section: Discussionsupporting

confidence: 83%

Increased plasma homocysteine levels without signs of vitamin B12 deficiency in patients with multiple sclerosis assessed by blood and cerebrospinal fluid homocysteine and methylmalonic acid

Vrethem¹,

Mattsson

Hebelka

et al. 2003

Mult Scler

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“…31 Goodkin et al identified macrocytosis in patients who had MS with normal vitamin B12 and folate levels, 29 although the results contradicted those of a similar study. 32 Goodkin et al, reported that low vitamin B12 levels do not lead to visible hematological defects. In our study, no statistically significant difference in MCV was observed between the control group and patients with MS.…”

Section: Discussionmentioning

confidence: 98%

Serum vitamin B12, folate, and homocysteine levels and their association with clinical and electrophysiological parameters in multiple sclerosis

Koçer¹,

Engür²,

Ak³

et al. 2009

Journal of Clinical Neuroscience

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“…While the conducted analysis showed no statistically significant changes in MCH after the use of WBC and in the baseline levels, a statistically significant minimal increase in MCHC was observed in healthy women after the use of WBC. Grasso et al (1992) found no pathological HGB values or deviation from the RBC norms in MS patients. They performed blood tests of MS patients and found no difference in MCV compared to the control group.…”

Section: Discussionmentioning

confidence: 64%

Effect of Whole-Body Cryotherapy on Morphological, Rheological and Biochemical Indices of Blood in People with Multiple Sclerosis

Ptaszek

Teległów

Adamiak

et al. 2021

JCM

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The aim of this study was to examine and assess the impact of a series of 20 whole-body cryotherapy (WBC) treatments on the biochemical and rheological indices of blood in people with multiple sclerosis. In this prospective controlled study, the experimental group consisted of 15 women aged 34–55 (mean age, 41.53 ± 6.98 years) with diagnosed multiple sclerosis who underwent a series of whole-body cryotherapy treatments. The first control group consisted of 20 women with diagnosed multiple sclerosis. This group had no intervention in the form of whole-body cryotherapy. The second control group consisted of 15 women aged 30–49 years (mean age, 38.47 ± 6.0 years) without neurological diseases and other chronic diseases who also underwent the whole-body cryotherapy treatment. For the analysis of the blood indices, venous blood was taken twice (first, on the day of initiation of whole-body cryotherapy treatments and, second, after a series of 20 cryotherapy treatments). The blood counts were determined using an ABX MICROS 60 hematological analyzer (USA). The LORCA analyzer (Laser–Optical Rotational Cell Analyzer, RR Mechatronics, the Netherlands) was used to study the aggregation and deformability of erythrocytes. The total protein serum measurement was performed using a Cobas 6000 analyzer, Roche and a Proteinogram-Minicap Sebia analyzer. Fibrinogen determinations were made using a Bio-Ksel, Chrom-7 camera. Statistically significant differences and changes after WBC in the levels of red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), elongation index, total extend of aggregation (AMP), and proteins (including fibrinogen) were observed. However, there was no significant effect of a series of 20 WBC treatments on changes in blood counts, rheology, and biochemistry in women with multiple sclerosis. Our results show that the use of WBC has a positive effect on the rheological properties of the blood of healthy women.

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Lack of association between macrocytosis and multiple sclerosis.

Cited by 6 publications

References 6 publications

Increased plasma homocysteine levels without signs of vitamin B12 deficiency in patients with multiple sclerosis assessed by blood and cerebrospinal fluid homocysteine and methylmalonic acid

Increased plasma homocysteine levels without signs of vitamin B12 deficiency in patients with multiple sclerosis assessed by blood and cerebrospinal fluid homocysteine and methylmalonic acid

Serum vitamin B12, folate, and homocysteine levels and their association with clinical and electrophysiological parameters in multiple sclerosis

Effect of Whole-Body Cryotherapy on Morphological, Rheological and Biochemical Indices of Blood in People with Multiple Sclerosis

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