Lack of association between mannose-binding lectin gene polymorphisms and primary Sjögren's syndrome

Mullighan, Charles G.; Heatley, Sue L.; Bardy, Peter; Lester, Sue; Rischmueller, Maureen; Gordon, Thomas P.

doi:10.1002/1529-0131(200012)43:12<2851::aid-anr28>3.0.co;2-w

Cited by 15 publications

(9 citation statements)

References 14 publications

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“…No difference in genotype or allele frequencies was detected between the pSS patients and controls. This ® nding is in concordance with that of Mullighan and associates (8), although they used the less strict European criteria for pSS. Wang and colleagues have, in turn, observed that 54 allele is more rare in Japanese pSS patients than in controls (10).…”

Section: Discussionsupporting

confidence: 90%

The significance of mannan-binding lectin gene alleles in patients with primary Sjo¨gren's syndrome

Aittoniemi

Pertovaara

Hulkkonen

et al. 2002

Scandinavian Journal of Rheumatology

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Section: Discussionsupporting

confidence: 90%

The significance of mannan-binding lectin gene alleles in patients with primary Sjo¨gren's syndrome

Aittoniemi

Pertovaara

Hulkkonen

et al. 2002

Scandinavian Journal of Rheumatology

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“…This association, however, is not observed in patients who did not produce anti-Ro52 autoantibodies [38]. Wang et al [40] 104 (143) Mullighan et al [42] 97 (106) Aittoniemi et al [43] 65 (138) Homozygous mutant allele Lupus and SS and rheumatoid factor…”

Section: Other Polymorphisms and Candidate Genes Ro52mentioning

confidence: 99%

“…Wang et al [40] 104 (143) Mullighan et al [42] 97 (106) Aittoniemi et al [43] 65 (138) Fas gene SS-Sjögren's syndrome; TAP-transporter associated with antigen processing; TNF␣-tumor necrosis factor-alpha.…”

Section: Mbl Promotermentioning

confidence: 99%

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The genetics of primary Sjögren’s syndrome

Sawalha¹,

Potts²,

Schmid³

et al. 2003

Curr Rheumatol Rep

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Primary Sjögren's syndrome is an autoimmune disease characterized clinically by dryness of the eyes and mouth. The use of different classification criteria for primary Sjögren's syndrome has led to dramatically different estimates of prevalence and incidence. Despite this, several genetic and environmental factors are thought to play a role in the susceptibility to primary Sjögren's syndrome, as is the current conceptual formulation of the pathogenesis of many other autoimmune maladies. Primary Sjögren's syndrome appears a complicated polygenic disorder with many genes interacting with environmental factors. Similar to many other polygenic autoimmune rheumatic diseases, human leukocyte antigen associations have been reported and confirmed. Additionally, other non-human leukocyte antigen candidate genes have been reported to reveal association with primary Sjögren's syndrome, but, in general, these effects are not confirmed. The authors review the human leukocyte antigen and non-human leukocyte antigen genetic associations herewith, knowing that new technologies are providing access to the entire genome for association studies. No doubt a much more comprehensive description of the genetics of this disorder will soon emerge.

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“…These include chemokine and cytokine polymorphisms for CCR5 [22] [26,27], perpetuating themes of relatively dysfunctional apoptotic genes being important autoimmunity risk factors.…”

Section: Genes Outside the Hla Regionmentioning

confidence: 99%

Horizons in Sjögren’s Syndrome Genetics

Williams

Cobb

Namjou

et al. 2007

Clinic Rev Allerg Immunol

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Sjögren's syndrome (SS) is a complex polygenic autoimmune disorder. A few major genetic effects have been identified. Historically, HLA and non-HLA genetic associations have been reported. Recently, the HLA region continued to reveal association findings. A new susceptibility region has been suggested by a study of a D6S349 microsatellite marker. Among non-HLA studies, recent association of immunoglobulin κ chain allotype KM1 with anti-La autoantibodies in primary Sjögren's syndrome confirms findings in a study from two decades ago. Meanwhile, mouse models have been employed to study the genetic contribution to salivary lymphadenitis or © Humana Press Inc. 2007 Correspondence to: John B. Harley, john-harley@omrf.ouhsc.edu. HHS Public Access Author Manuscript Author ManuscriptAuthor ManuscriptAuthor Manuscript dry eyes and mouth. Gene transfer exploration in mouse models shows promise. The authors review the HLA and non-HLA association studies and the mouse model work that has been reported. Newly developed genomic capacity will provide, in the future, a much closer approximation of the true picture of the genetic architecture of Sjögren's syndrome.

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Lack of association between mannose-binding lectin gene polymorphisms and primary Sjögren's syndrome

Cited by 15 publications

References 14 publications

The significance of mannan-binding lectin gene alleles in patients with primary Sjo¨gren's syndrome

The significance of mannan-binding lectin gene alleles in patients with primary Sjo¨gren's syndrome

The genetics of primary Sjögren’s syndrome

Horizons in Sjögren’s Syndrome Genetics

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