Lack of association between peripheral neuropathy and HTLV-I infection in West Africa

Vallat, Jean‐Michel; Dumas, Michel; Grunitzky, E. K.; Akani, F; Diop, G; Ramiandrisoa, H.; Denis, F.

doi:10.1016/0022-510x(93)90126-j

Cited by 8 publications

(5 citation statements)

References 12 publications

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“…With one exception (vide infra), electron microscopy has failed to demonstrate viral particles (Bhigjee et al 1993 ;Sugimura et al 1990 ). Focal paranodal myelin swellings were noted in two reports (Bhigjee et al 1993 ;Sugimura et al 1990 )) but were not found in a third study (Vallat et al 1993 ). Ultrastructural examination of the myelin swellings showed redundancy and excessive folding of the myelin, frequently with globular degeneration.…”

Section: Pathologymentioning

confidence: 90%

“…Neuropathy is present in 16-32 % of these patients (Bhigjee et al 1993 ), although other workers have failed to fi nd a signifi cant association between HTLV-I seropositivity and peripheral neuropathy (Vallat et al 1993 ). Worldwide, HTLV-I is a rare pathogen except in Japan, the Caribbean, and parts of Africa HLTV-I (Gessain and Gout 1992 ).…”

Section: Clinical Featuresmentioning

confidence: 97%

“…The distal symmetrical neuropathies seen in HTLV-I infection is similar to that of HIV infection, and a common, as yet undefi ned, mechanism may be at work. It is only fair to note that some authors have found no evidence to suggest that HTLV-I is causally associated with peripheral neuropathy (Vallat et al 1993 ).…”

Section: Pathologymentioning

confidence: 97%

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Bilbao

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2014

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Section: Pathologymentioning

confidence: 90%

Section: Clinical Featuresmentioning

confidence: 97%

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Infectious Diseases Causing Neuropathy

Bilbao

Schmidt

2014

Biopsy Diagnosis of Peripheral Neuropathy

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“…In most countries in Africa, clinical neuroscience research focused on understanding the rationale and improving treatment of neurological disorders, including epilepsy, infections (predominantly cerebral malaria, meningitis, encephalitis, poliomyelitis, leprosy, tetanus), nutritional neuropathies, stroke, tumors, motor disorders and the adverse effects of snake venom (Lambo, 1956 ; Osuntokun et al, 1968 ; Dada et al, 1969 ; Kramer et al, 1971 ; Wangai et al, 1978 ; Anderson et al, 1985 ; Tazir and Geronimi, 1990 ; Bhigjee et al, 1993 ; Vallat et al, 1993 ; Hentati et al, 1994 ; Ogunniyi, 2010 ). Significant advances were made.…”

Section: Progress In the Twentieth And Twenty-first Centurymentioning

confidence: 99%

Notes on the Recent History of Neuroscience in Africa

Russell

2017

Front. Neuroanat.

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Neuroscience began with neuroanatomy and neurosurgery in Egypt more than 5000 years ago. Knowledge grew over time and specialized neurosurgery centers were established in north Africa in the eleventh century. However, it was not until the twentieth century that neuroscience research became established in sub-Saharan Africa. In most African countries, clinical research focused on understanding the rationale and improving treatment of epilepsy, infections, nutritional neuropathies, stroke and tumors. Significant advances were made. In the twenty-first century, African knowledge expanded to include all branches of neuroscience, contributing to genetic, biochemical and inflammatory determinants of brain disorders. A major focus of basic neuroscience research has been, and is, investigation of plant extracts, drugs and stress in animal models, providing insight and identifying potential novel therapies. A significant event in the history of African neuroscience was the founding of the Society of Neuroscientists of Africa (SONA) in 1993. The International Brain Research Organization (IBRO) supported SONA conferences, as well as workshops and neuroscience training schools in Africa. Thanks to their investment, as well as that of funding agencies, such as the National Institutes of Health (NIH), International Society for Neurochemistry (ISN), World Federation of Neurosurgical Societies (WFNS), World Federation of Neurology (WFN) and the International League Against Epilepsy (ILAE), neuroscience research is well-established in Africa today. However, in order to continue to develop, African neuroscience needs continued international support and African neuroscientists need to engage in policy and decision-making to persuade governments to fund studies that address the unique regional needs in Africa.

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“…Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus implicated in a number of disorders, and they were one of the first groups to have conducted several surveys in West Africa to determine the seroprevalence and incidence of HTLV-1, and to have demonstrated a familial transmission and clustering of this viral disease in this subregion [6,7]. They had also demonstrated a correlation of HTLV-1 with spastic paraparesis, as well as with lifestyle, environmental and geographic factors, and with concomitant infections such as filariasis.…”

Section: Human T-lymphotropic Virus Typementioning

confidence: 99%

Michel Dumas and Pierre-Marie Preux: Promoting Tropical Neurology Silently - The Gist of Their Contributions

Bhalla¹

2014

Neuroepidemiology

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This article presents the contribution by two senior French Neurologists over the past three decades in building, developing and promoting ‘tropical neurology' in a number of neglected countries of Asia, Africa and Latin America. It talks about the ‘human, dedicational and contributive value' of these two experts who do not come from an English-speaking world. It highlights meaningful changes that have been achieved in different tropical countries as a result of their direct contribution. This overview may likely be a cause for learning and motivation to others to really work in and for tropical countries, where a large proportion of global health burden is to be found.

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Lack of association between peripheral neuropathy and HTLV-I infection in West Africa

Cited by 8 publications

References 12 publications

Infectious Diseases Causing Neuropathy

Infectious Diseases Causing Neuropathy

Notes on the Recent History of Neuroscience in Africa

Michel Dumas and Pierre-Marie Preux: Promoting Tropical Neurology Silently - The Gist of Their Contributions

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