Lack of Association between Polymorphisms of the Dopamine Receptor D4 and Dopamine Transporter Genes and Personality Traits in a Korean Population

Kim, Se Joo; Kim, Young S.; Kim, Chan-Hyung; Lee, Hong Shick

doi:10.3349/ymj.2006.47.6.787

Cited by 26 publications

(14 citation statements)

References 33 publications

(52 reference statements)

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“…However, our present study of total, male or female subjects identified no significant association between any of the 3 tested SNPs in the NTR1 gene, which is closely connected to the dopamine system, and NS scores, suggesting that NTR1 is not a defining factor in the NS temperament dimension, at least in the Chinese Han genetic background. In fact, the current results are consistent with those of many previous studies that found no associations between DRD2 [44], DRD4 [44,45,46,47,48], and dopamine transporter 1 [47] gene variants and NS in different healthy populations, and that did not replicate the results that variants in the genes encoding proteins in the dopamine system were related to NS trait scores.…”

Section: Discussionsupporting

confidence: 81%

Neurotensin Receptor 1 Gene Polymorphisms Are Associated with Personality Traits in Healthy Chinese Individuals

Huang

Zhang

et al. 2013

Neuropsychobiology

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Aims: Neurotensin receptor 1 (NTR1) is a neurotensin (NT) receptor subtype with a high affinity for NT. NT and NTR1 signaling are involved in modulating the dopamine system. Individual variations in the dopamine system have been demonstrated to determine certain dimensions of personality, but no studies have thus far investigated the involvement of the NTR1 in the biological determination of personality. We therefore examined this link in a Chinese Han population. Methods: We genotyped 3 single nucleotide polymorphisms (SNPs) (rs6090453C/G, rs6011914C/G, and rs2427422A/G) of the NTR1 gene and collected the data about the personality traits of novelty seeking (NS), harm avoidance (HA), and reward dependence (RD), as well as their subscales (measured by the Tridimensional Personality Questionnaire), in 575 healthy Chinese Han subjects. Then we examined the association between the 3 NTR1 gene polymorphisms and each personality trait. Results: There were significant differences in the HA2, HA3 and RD1 scores between rs6090453C/G genotypes (F = 3.425, 5.651, 4.054, p = 0.033, 0.004, 0.018, respectively), in the HA2 and total RD scores between rs6011914C/G genotypes (F = 4.080, 3.712, p = 0.017, 0.025, respectively), and in the total RD (χ² = 7.301, p = 0.026) and RD3 (F = 4.119, p = 0.017) scores between the rs2427422A/G genotypes. There were significant male-specific differences in the RD1 scores between the rs6090453C/G genotypes (F = 3.334, p = 0.037), in the total HA (F = 3.043, p = 0.049), HA2 (F = 4.472, p = 0.012) and RD3 (χ² = 6.997, p = 0.030) scores between the rs6011914C/G genotypes, and in the HA2 (F = 3.177, p = 0.043), total RD (χ² = 7.032, p = 0.030), and RD3 (F = 4.563, p = 0.011) scores between the rs2427422A/G genotypes. We also demonstrated a significant female-specific difference in the total RD scores between the rs6011914C/G genotypes (F = 3.677, p = 0.026). There was no significant difference in the total NS and subscale scores between the genotypes of all 3 SNPs (all p > 0.05). Conclusions: The variations in the NTR1 gene were involved in the biological mechanisms of HA and RD personality traits; however, the effect is influenced by gender.

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Section: Discussionsupporting

confidence: 81%

Neurotensin Receptor 1 Gene Polymorphisms Are Associated with Personality Traits in Healthy Chinese Individuals

Huang

Zhang

et al. 2013

Neuropsychobiology

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“…However, one study implies that an A/G SNP in the 10 allele may be associated with vulnerability to alcoholism [136]. To a lesser extent other associations with this VNTR have been examined but most find no correlation, these include; body weight, body mass index or obesity [137], Tourette's [138], personality traits (novelty seeking, harm avoidance, reward dependence and persistence [139]), cocaine dependence [140]; and schizophrenia [141].…”

Section: -Htt Variants and Anti-depressant Efficacymentioning

confidence: 98%

Molecular Genetics of Monoamine Transporters: Relevance to Brain Disorders

et al. 2007

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We have demonstrated in both the human serotonin transporter gene (5HTT) and the dopamine transporter gene (DAT1) that specific polymorphic variants termed Variable Number Tandem Repeats (VNTRs), which correlate with predisposition to a number of neurological and psychiatric disorders, act as transcriptional regulatory domains. We have demonstrated that these domains can act as both tissue-specific and stimulus-inducible regulators of gene expression. As such they can act to be mechanistically associated with the progression or initiation of a behavioural disorder by altering the level of transporter mRNA, which in turn regulates the concentration of transporter in specific cells or in response to a challenge; chemical, environmental or physiological. The synergistic actions of such transcriptional domains will modulate gene expression. Our hypothesis is that these VNTR variants are one mechanism by which nurture can modify concentrations of neurotransmitters in a differential manner.

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“…For mer stu di es re ve a led conf lic ting results on DRD4 or 5-HT2A poly morp hisms and novelty se e king. In so me stu di es, no velty se e king was shown to be re la ted with DRD4 poly morpTurkiye Klinikleri J Med Sci 2010;30 (5) [19][20][21] Se veral stu di es ob ser ved as so ci a ti ons bet we en 5-HT2A and no velty se e king. 22 In con trast, some stu di es reve a led that 5-HT2A was ne ga ti vely re la ted with cons ci en ti o us ness 23 and po si ti vely cor re la ted with ne u ro ti cism (emo ti o nal sta bi lity).…”

Section: Discussionmentioning

confidence: 99%

Personality Traits and DRD4, DAT1, 5-HT2A Gene Polymorphisms in Risky and Non Risky Sports Participation

Çam¹,

Çolakoğlu²,

Tok³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Re la ti ons hips amongst Big Fi ve per so na lity tra its and DRD4, DAT1 and 5-HT2A ge ne poly morp hisms we re in ves ti ga ted in 193 col le ge stu dents par ti ci pa ting in risky and non-risky sports. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : Per so na lity tra its we re as ses sed by Fi ve Fac tor Per so na lity In ven tory (FFPI) and ge ne poly morp hisms we re analy zed by poly me ra se cha in reac ti on. R Re e s su ul lt ts s: : In or der to exa mi ne whet her sig ni fant Big Fi ve per so na lity tra it dif fe ren ces exis ted bet we en DAT1 ge ne po li morp hisms, in de pen dent samp le t-test was used. Re sults sho wed that only Ag re e ab le ness di men si on re ve a led sig ni fi cant dif fe ren ce in di ca ting that in di vi du als with non-10/10 ge noty pe had hig her ag re e ab le ness sco res when com pa red to in di vi du als with 10/10 ge noty pe. ANO VA re sults sho wed that Big Fi ve per so na lity di men si ons sco res dif fe red sig ni fi cantly amongst 5-HT2A ge noty pes. In di vi du als with CC ge noty pe had lo wer emo ti o nal sta bi lity sco res when com pa red to in di vi du als with TC ge noty pe, and CC ge noty pe in di vi du als had gre a ter open ness to ex pe ri en ce sco res when com pa red to TT ge noty pe in di vi du als. Openness to ex pe ri en ce sco res we re al so sig ni fi cantly dif fe rent among DRD4 ge noty pes. In di vi du als with ll ge noty pe had gre a ter open ness to ex pe ri en ce sco res when com pa red to in di vi du als with ss ge noty pe. No 5-HT2A and risky sport par ti ci pa ti on (RSP) in te rac ti on ef fect was fo und on emo ti o nal chan ge sco re. C Co on nc c l lu u s si i o on n: : DAT1 was not as so ci a ted with RSP. It was conc lu ded that DRD4 and 5-HT2A we re not di rectly as so ci a ted with RSP but may be used as in di rect pre dictors of it.K Ke ey y W Wo or rd ds s: : Poly morp hism, ge ne tic; per so na lity Ö ÖZ ZE ET T A Am ma aç ç: : Bu araş tır ma da risk li ve risk siz spor la ra ka tı lım da ki şi lik özel lik le ri ile DRD4, DAT1, 5HT2A gen po li mor fizm le ri ara sın da ki iliş ki, risk li ve risk siz spor la ra ka tı lan 193 üni ver si te öğ renci sin de araş tı rıl mış tır. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Ki şi lik özel lik le ri Beş Fak tör lü Ki şi lik En van te ri ile öl -çül müş, gen po li mor fizm le ri po li me raz zin cir rek si yo nu ile tes pit edil miş tir. B Bu ul l g gu u l la ar r: : Beş ana ki şi lik özel li ği nin DAT1 gen po li mor fizm le ri ara sın da fark lı lık gös te rip gös ter me di ği ni in ce le mek için bağım sız iki ör nek t tes ti kul la nıl mış ve non-10/10 ge no ti pe sa hip bi rey le rin da ha yük sek "yu mu şak -baş lı lık" sko ru el de et tik le ri bu lun muş tur. 5-HT2A gen po li mor fizm le ri ara sın da ki şi lik fark lı lık la rı nı in ce le mek için ya pı lan var yans ana li zi so nu cun da ise CC ge no ti pi ne sa hip bi rey le rin, TC ge no ti pi ne sa hip bi rey ler den da ha dü şü...

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Lack of Association between Polymorphisms of the Dopamine Receptor D4 and Dopamine Transporter Genes and Personality Traits in a Korean Population

Cited by 26 publications

References 33 publications

Neurotensin Receptor 1 Gene Polymorphisms Are Associated with Personality Traits in Healthy Chinese Individuals

Neurotensin Receptor 1 Gene Polymorphisms Are Associated with Personality Traits in Healthy Chinese Individuals

Molecular Genetics of Monoamine Transporters: Relevance to Brain Disorders

Personality Traits and DRD4, DAT1, 5-HT2A Gene Polymorphisms in Risky and Non Risky Sports Participation

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