Lack of Association Between Proliferative Verrucous Leukoplakia and Human Papillomavirus Infection

Bagán, José; Jiménez, Yolanda; Murillo, Judith; Gavaldá, Carmen; Poveda, Rafael; Scully, Crispian; Alberola, Trinidad M.; Torres-Puente, Manuela; Pérez-Alonso, Manuel

doi:10.1016/j.joms.2005.12.066

Cited by 87 publications

(85 citation statements)

References 16 publications

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“…Cancer Epidemiol Biomarkers Prev 2008;17 (11). November 2008 software as described previously with the modification that P53-positive staining in the range of 10% to 24.9%, 25% to 39.9%, and z40% were designated +, ++, and +++, respectively.…”

Section: Cancer Epidemiology Biomarkers and Preventionmentioning

confidence: 99%

“…Silverman et al reported 68% of PVL patients to be positive for Candida albicans but did not find the fungal infection to be linked PVL occurrence or progression to carcinoma (2). To date, several studies in relatively small cohorts have investigated the role of HPV in verrucous lesions reporting between 0% and 89% of PVL lesions to be HPV positive (3,(5)(6)(7)(8)(9)(10)(11). Conflicting results with respect to HPV have also been reported for SCCs and verrucous carcinomas (12,13); however, one of the largest studies evaluating HPV in verrucous and conventional leukoplakias reported HPV DNA rates of 24.1% and 25.5%, respectively (3).…”

Section: Introductionmentioning

confidence: 99%

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Frequent Alterations of p16INK4a and p14ARF in Oral Proliferative Verrucous Leukoplakia

Kresty

Mallery²,

Knobloch

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Proliferative verrucous leukoplakia (PVL) represents a rare but highly aggressive form of oral leukoplakia with >70% progressing to malignancy. Yet, PVL remains biologically and genetically poorly understood. This study evaluated the cell cycle regulatory genes, p16 INK4aand p14 ARF , for homozygous deletion, loss of heterozygosity, and mutation events in 20 PVL cases. Deletion of exon 1B, 1A, or 2 was detected in 40%, 35%, and 0% of patients, respectively. Deletions of exons 1A and 1B markedly exceed levels reported in non-PVL dysplasias and approximate or exceed levels reported in oral squamous cell carcinomas. Allelic imbalance was assessed for markers reported to be highly polymorphic in squamous cell carcinomas and in oral dysplasias. Loss of heterozygosity was detected in 35.3%, 26.3%, and 45.5% of PVLs for the markers IFNa, D9S1748, and D9S171, respectively. INK4a and ARF sequence alterations were detected in 20% and 10% of PVL lesions, accordingly. These data show, for the first time, that both p16INK4a and p14 ARF aberrations are common in oral verrucous leukoplakia; however, the mode and incidence of inactivation events differ considerably from those reported in non-PVL oral premalignancy. Specifically, concomitant loss of p16INK4a and p14 ARF occurred in 45% of PVL patients greatly exceeding loss reported in non-PVL dysplastic oral epithelium (15%). In addition, p14 ARF exon 1B deletions were highly elevated in PVLs compared with non-PVL dysplasias. These data illustrate that molecular alterations, even within a specific genetic region, are associated with distinct histologic types of oral premalignancy, which may affect disease progression, treatment strategies, and ultimately patient prognosis. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3179 -87)

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Section: Cancer Epidemiology Biomarkers and Preventionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Frequent Alterations of p16INK4a and p14ARF in Oral Proliferative Verrucous Leukoplakia

Kresty

Mallery²,

Knobloch

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Some authors suggested PVL might have an infectious etiologypossibly a viral infection like HPV or EBV. Although several authors have suggested that HPV might have a role in the pathogenesis of PVL, 4 Bagan et al failed to find HPV in their group of patients and suggested that there is no association of PVL with HPV, 6 rather in their studies they have detected the presence of EBV in a large percent of patients. 5 A number of the reported cases of PVL have initially presented as a solitary flat homogenous leukoplakia, while others present with multiple involved sites at time of diagnosis.…”

Section: Discussionmentioning

confidence: 92%

Rapidly progressive proliferativeverrucous leukoplakia - Case report & Diagnostic difficulties

Kumar‐M¹,

P²,

T³

et al. 2011

IJDA

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“…An interesting data reported by Kim et al (28), found the HPV DNA integrated into 94.1% of the examined SCCs, and the significant correlation between HPV-DNA integration and cell cycle alteration is well known. The most alarming data is that, according to the latest epidemiological studies, due to the success of alcoholism and tobacco awareness campaigns, confirmed by the reduction of new cases of SCC oral and alcoholrelated, the annual incidence of HPV verrucous carcinoma of oropharynx has increased exponentially over the last twenty years, so that it is estimated that by 2020 their frequency will be higher than SCCs in the uterine cervix and in the anogenital tract (29). From a prognostic point of view, it has been observed that subjects with positive HPV-SCC of oropharynx have a more favourable prognosis than negative HPV.…”

Section: Malignant Lesionsmentioning

confidence: 99%

HPV Infection in the Oral Cavity: Epidemiology, Clinical Manifestations and Relationship With Oral Cancer

Candotto

Lauritano

Nardone

et al. 2017

ORL

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209nomas (OPSCCs) (3, 4). The etiologic role of human papillomavirus infection in the development of Squamous Cell Carcinomas (SCC) of the uterine cervix has been widely demonstrated, so that this tumour is caused, in almost of the cases, by the persistent infectious status by high-risk atypical genotypes. There is also strong evidence to support a causal role of these viruses in the etiopathogenesis of SCC, both in the anogenital area and in the head area (for example, pharynx, larynx and oral cavity) (5). Genital HPV infection is one of SUMMARY Purpose. The aim of this paper is to describe epidemiology and clinical manifestations of oral infection by Human papillomavirus (HPV), with particular attention to potential malignant lesions. Materials and methods. A systematic review of the literature was conducted to describe the state of the art about HPV infection in oropharyngeal mucosa and its modalities of transmission, with particular attention to possible simultaneous infection in multiple anatomic sites. The aspects of prevention and control of infection by administering vaccines and the diffusion of sexual education campaigns are discussed also. Therapeutic protocols are also described where necessary. Results. In recent years there has been a growing interest in HPV oral medicine, suggesting a role of such a family of viruses in the development of neoplasms of the oropharyngeal district as well as of the uterine cervix. Even if the mass media have increasingly faced the problem, causing frequent alarming among patients, the dentist therefore needs a complete and up-to-date knowledge of this infectious condition that is one of the most common causes of sexually transmitted mucous membrane infections (e.g. genital, anal and oral). Conclusions. Recent studies about HPV infection are a basic requirement in order to promote the health of patients and provide them with the most exhaustive indications from dentists.

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Lack of Association Between Proliferative Verrucous Leukoplakia and Human Papillomavirus Infection

Cited by 87 publications

References 16 publications

Frequent Alterations of p16INK4a and p14ARF in Oral Proliferative Verrucous Leukoplakia

Frequent Alterations of p16INK4a and p14ARF in Oral Proliferative Verrucous Leukoplakia

Rapidly progressive proliferativeverrucous leukoplakia - Case report & Diagnostic difficulties

HPV Infection in the Oral Cavity: Epidemiology, Clinical Manifestations and Relationship With Oral Cancer

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