Lack of Association between PTPN22 Gene +1858 C>T Polymorphism and Susceptibility to Generalized Vitiligo in a Turkish Population

Abstract

BackgroundVitiligo is an autoimmune polygenic disorder characterized by loss of pigmentation due to melanocyte destruction. The PTPN22 gene +1858 C>T single nucleotide polymorphism (rs2476601) has been shown to be associated with various autoimmune disorders.ObjectiveThe aim of this study was to investigate whether the PTPN22 gene +1858 C>T single nucleotide polymorphism is associated with susceptibility to generalized vitiligo in a Turkish population.MethodsOne hundred and seven patients with generalized vitiligo, and one hundred and twelve gender-, age-, and ethnic-matched controls were enrolled in the study. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism.ResultsThe PTPN22 +1858 C>T genotype and allele frequencies of the generalized vitiligo patients did not differ significantly from those of healthy controls.ConclusionWe found no association between the PTPN22 +1858 C>T gene polymorphism and vitiligo susceptibility in Turkish generalized-vitiligo patients.

Catalase but not vitamin D receptor gene polymorphisms are associated with nonsegmental vitiligo in Northwestern Mexicans

“…Our results show that CAT ‐89 TT genotype and T allele are associated with an increased risk of developing vitiligo ( P = 0.015, OR = 2.265 and P = 0.008, OR = 1.618), corroborating the findings in Chinese, Indian, and Italian populations and the suggestion that CAT ‐89 T allele contributes to the risk of developing vitiligo because of its position in the promoter of CAT gene relating to a decrease in its transcription rate . However, this SNP was not found associated with vitiligo in Turkish and Korean populations, which might be attributed to ethnicity considering the interpopulation variation in ‐89 A/T polymorphism …”

Association of the 389 C/T polymorphism of the catalase gene with susceptibility to vitiligo: a meta-analysis

“…However, Bulut et al . and Akbas et al . could not find this association in Turkish patients with vitiligo.…”

“…Seven relevant studies were finally identified, relating CAT gene 389 C/T polymorphisms to risk of vitiligo. They comprised 1531 patients with vitiligo and 1608 controls . Four studies originated from North America and Europe, including two from Turkey .…”

“…They comprised 1531 patients with vitiligo and 1608 controls . Four studies originated from North America and Europe, including two from Turkey . The other three studies were from Asia .…”

“…It has been reported some single‐nucleotide polymorphisms and mutations of CAT may increase the risk for developing vitiligo . Several primary studies have evaluated the association between CAT gene polymorphisms in codon 389 of exon 9 (rs769217) and susceptibility to vitiligo, but the results are still conflicting.…”