Lack of Association Between TGF-β1 and MDR1 Genetic Polymorphisms and Cyclosporine-Induced Gingival Overgrowth in Kidney Transplant Recipients: A Meta-analysis

Wang, K.; Wang, Zu-Heng; Si, Shuhui; Liu, X.; Han, Ze‐Guang; Tao, Jun; Chen, H.; Suo, Chuanjian; Wei, Jing; Tan, Ruoyun; Gu, Min

doi:10.1016/j.transproceed.2017.01.080

Cited by 2 publications

(2 citation statements)

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“…The meta-analysis by Wang et al [35] analyzed the association between transforming growth factor beta-1 (TGF-ß1) gene polymorphism and CsA induced gingival overgrowth; the authors suggested that the codon 10 polymorphism in TGF-ß1 is not associated with susceptibility to CsA-induced gingival enlargement. However, while it has been established that TGF-ß1 plays a crucial role in the pathogenesis of CsA-induced gingival enlargement, the data reported in the literature regarding this point are controversial.…”

Section: Discussionmentioning

confidence: 99%

Drug-Induced Gingival Overgrowth: A Pilot Study on the Effect of Diphenylhydantoin and Gabapentin on Human Gingival Fibroblasts

Lauritano

Moreo

Limongelli

et al. 2020

IJERPH

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Introduction. The administration of several classes of drugs can lead to the onset of gingival overgrowth: anticonvulsants, immunosuppressants, and calcium channel blockers. Among the anticonvulsants, the main drug associated with gingival overgrowth is diphenylhydantoin. Materials and Methods. In this study, we compared the effects of diphenylhydantoin and gabapentin on 57 genes belonging to the “Extracellular Matrix and Adhesion Molecule” pathway, present in human fibroblasts of healthy volunteers. Results. Both molecules induce the same gene expression profile in fibroblasts as well as a significant upregulation of genes involved in extracellular matrix deposition like COL4A1, ITGA7, and LAMB3. The two treatments also induced a significant downregulation of genes involved in the expression of extracellular matrix metalloproteases like MMP11, MMP15, MMP16, MMP24, and transmembrane receptor ITGB4. Conclusions. Data recorded in our study confirmed the hypothesis of a direct action of these drugs at the periodontium level, inducing an increase in matrix production, a reduction in its degradation, and consequently resulting in gingival hyperplasia.

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Section: Discussionmentioning

confidence: 99%

Drug-Induced Gingival Overgrowth: A Pilot Study on the Effect of Diphenylhydantoin and Gabapentin on Human Gingival Fibroblasts

Lauritano

Moreo

Limongelli

et al. 2020

IJERPH

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“…Результаты и выводы различных исследований генетического полиморфизма TGFB1 у реципиентов солидных органов не всегда однозначны, что может быть связано с недостаточным количеством изучаемых случаев, этнической неоднородностью выборки, а также с различиями в определении исследуемых фенотипов и применением различных методов анализа. Для обобщения разнородных исследований часто используют метаанализ и систематические обзоры, которые проводятся в соответствии с определенными стандартами и позволяют, как полагают, привести к общему знаменателю разобщенные данные [18,28,43].…”

Section: Abstract: Single-nucleotide Polymorphism Graft Rejection Graft Fibrosis Graft Dysfunctionunclassified

The role of TGF-β1 gene polymorphisms in the development of post-transplant complications

Курабекова

Гичкун

Мещеряков

et al. 2021

RJTAO

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Transforming growth factor beta 1 (TGF-β1) is an immunosuppressive and profibrogenic cytokine capable of influencing the development of graft rejection and graft fibrosis in solid organ recipients. The TGF-β gene has a significant polymorphism that may cause individual protein expression levels and be associated with post-organ transplant complications. It is believed that three TGFB1 polymorphic variants (rs1800469, rs1800470 and rs1800471) may be associated with the development of graft rejection, graft fibrosis and chronic dysfunction of a heart, liver or kidney transplant. A review of current literature presents the results of studies on the relationship between TGF-β1 gene polymorphisms and post-transplant complications in solid organ recipients. The findings of various studies of TGF-β1 gene polymorphism in solid organ recipients are not always unambiguous, and their results are often difficult to generalize even with the help of meta-analysis. Samples included in studies vary in terms of ethnicity, gender, age, and underlying medical conditions, while results are highly dependent on sample structure or latent relatedness. Currently available data suggest that TGFB1 polymorphism may determine a predisposition to the development of graft rejection, graft fibrosis and graft dysfunction in solid organ recipients, but this is not conclusive and requires further, larger studies.

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Lack of Association Between TGF-β1 and MDR1 Genetic Polymorphisms and Cyclosporine-Induced Gingival Overgrowth in Kidney Transplant Recipients: A Meta-analysis

Cited by 2 publications

References 43 publications

Drug-Induced Gingival Overgrowth: A Pilot Study on the Effect of Diphenylhydantoin and Gabapentin on Human Gingival Fibroblasts

Drug-Induced Gingival Overgrowth: A Pilot Study on the Effect of Diphenylhydantoin and Gabapentin on Human Gingival Fibroblasts

The role of TGF-β1 gene polymorphisms in the development of post-transplant complications

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