Lack of Association Between the CYP1A1 Ile462Val Polymorphism and Endometrial Cancer Risk: a Meta-analysis

Wang, Xiwen; Zhong, Tianyu; Xiong, Yun-Hui; Lin, Haibo; Liu, Qing-Yi

doi:10.7314/apjcp.2012.13.8.3717

Cited by 11 publications

(6 citation statements)

References 29 publications

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“…Catalytic activity of JMJD2A was required for its ability to stimulate maximally estrogen-dependent gene transcription. It is well known that endometrial carcinoma is frequent estrogen-sensitive malignancy (Wang et al, 2011). ERα plays a pivotal role in the genesis of the majority of endometrial carcinomas (Arafa et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Expression and Effects of JMJD2A Histone Demethylase in Endometrial Carcinoma

Wang¹,

Liu²,

Ma³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Previous studies have demonstrated that JMJD2A is a potential oncogene and is overexpressed in human tumors. However, its role in the endometrial carcinoma remains largely unknown. In this study, we discovered that JMJD2A was overexpressed in endometrial carcinoma, using immunohistochemistry, quantitative realtime polymerase chain reaction, and western blotting. Downregulation of JMJD2A led to reduced endometrial carcinoma RL95-2 and ISK cell proliferation, invasion and metastasis as asessed with cell counting kit-8, cell migration and invasive assays. Collectively, our results support that JMJD2A is a promoter of endometrial carcinoma cell proliferation and survival, and is a potential novel drug target.

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Section: Discussionmentioning

confidence: 99%

Expression and Effects of JMJD2A Histone Demethylase in Endometrial Carcinoma

Wang¹,

Liu²,

Ma³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…We excluded studies where endometrial cancer incidence and mortality were not the primary outcomes, studies with benign endometrial pathologies as the primary outcomes of interest (such as fibroids or endometrial polyps), studies exploring the impact of genetic factors as well as studies assessing prognostic risk factors among women diagnosed with endometrial cancer (Supporting Information Figure 1). We further excluded narrative reviews and meta‐analyses that had only one study, did not report the necessary study‐specific data including the relative risk (RR) and 95% confidence intervals (CI) or the number of endometrial cancer cases and controls or total population . Where two or more meta‐analyses examined the exact same association, we chose the largest meta‐analysis to avoid duplicate assessment of the same primary studies; the concordance between included and duplicate meta‐analyses was explored in a sensitivity analysis (Supporting Information).…”

Section: Methodsmentioning

confidence: 99%

Risk factors for endometrial cancer: An umbrella review of the literature

Raglan

Kalliala

Markozannes

et al. 2019

Intl Journal of Cancer

392

289

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Although many risk factors could have causal association with endometrial cancer, they are also prone to residual confounding or other biases which could lead to over‐ or underestimation. This umbrella review evaluates the strength and validity of evidence pertaining risk factors for endometrial cancer. Systematic reviews or meta‐analyses of observational studies evaluating the association between non‐genetic risk factors and risk of developing or dying from endometrial cancer were identified from inception to April 2018 using PubMed, the Cochrane database and manual reference screening. Evidence was graded strong, highly suggestive, suggestive or weak based on statistical significance of random‐effects summary estimate, largest study included, number of cases, between‐study heterogeneity, 95% prediction intervals, small study effects, excess significance bias and sensitivity analysis with credibility ceilings. We identified 171 meta‐analyses investigating associations between 53 risk factors and endometrial cancer incidence and mortality. Risk factors were categorised: anthropometric indices, dietary intake, physical activity, medical conditions, hormonal therapy use, biochemical markers, gynaecological history and smoking. Of 127 meta‐analyses including cohort studies, three associations were graded with strong evidence. Body mass index and waist‐to‐hip ratio were associated with increased cancer risk in premenopausal women (RR per 5 kg/m2 1.49; CI 1.39–1.61) and for total endometrial cancer (RR per 0.1unit 1.21; CI 1.13–1.29), respectively. Parity reduced risk of disease (RR 0.66, CI 0.60–0.74). Of many proposed risk factors, only three had strong association without hints of bias. Identification of genuine risk factors associated with endometrial cancer may assist in developing targeted prevention strategies for women at high risk.

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“…Moreover, a meta-analysis suggests that -48G/C, -119G/T and -453A/G polymorphisms have no influence on the risk of breast cancer [66]. -432G/C polymorphism has also been reported without association of endometrial cancer risk [67] and postmenopausal breast cancer risk [68].…”

Section: Association Of Cyp1b1 Polymorphisms and Risk Of Cancermentioning

confidence: 99%

Role of Metabolic Enzymes P450 (CYP) on Activating Procarcinogen and their Polymorphisms on the Risk of Cancers

He¹,

Feng²

2015

CDM

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Cytochrome P450 (CYP450) enzymes are the most important metabolizing enzyme family exists among all organs. Apart from their role in the deactivation of most endogenous compounds and xenobiotics, they also mediate most procarcinogens oxidation to ultimate carcinogens. There are several modes of CYP450s activation of procarcinogens. 1) Formation of epoxide and diol-epoxides intermediates, such as CYP1A1 and CYP1B1 mediates PAHs oxidation to epoxide intermediates; 2) Formation of diazonium ions, such as CYP2A6, CYP2A13 and CYP2E1 mediates activation of most nitrosamines to unstable metabolites, which can rearrange to give diazonium ions. 3) Formation of reactive semiquinones and quinines, such as CYP1A1 and CYP1B1 transformation of estradiol to catechol estrogens, subsequently formation semiquinones; 4) Formation of toxic O-esterification, such as CYP1A1 and CYP1A2 metabolizes PhIP to N(2)-acetoxy-PhIP and N(2)-sulfonyloxy-PhIP, which are carcinogenic metabolites. 5) Formation of free radical, such as CYP2E1 is involved in activation tetrachloromethane to free radicals. While for CYP2B6 and CYP2D6, only a minor role has been found in procarcinogens activation. In addition, as the gene polymorphisms reflected, the polymorphisms of CYP1A1 (-3801T/C and -4889A/G), CYP1A2 (- 163C/A and -2467T/delT), CYP1B1 (-48G/C, -119G/T and -432G/C), CYP2E1 (-1293G/C and -1053 C/T) have been associated with an increased risk of lung cancer. The polymorphisms CYP1A1 (-3801T/C and -4889A/G), and CYP2E1 (PstI/Rsa and 9-bp insertion) have an association with higher risk colon cancers, whereas CYP1A2 (-163C/A and -3860G/A) polymorphism is found to be among the protective factors. The polymorphisms CYP1A1 (-3801T/C and -4889A/G), CYP1B1 -432G/C, CYP2B6 (-516G/T and -785A/G) may increase the risk of breast cancer. In conclusion, CYP1A1, CYP1A2, CYP1B1, CYP2A6, and CYP2E1 are responsible for most of the procarcinogens activation, and their gene polymorphisms are associated with the risk of cancers.

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Lack of Association Between the CYP1A1 Ile462Val Polymorphism and Endometrial Cancer Risk: a Meta-analysis

Cited by 11 publications

References 29 publications

Expression and Effects of JMJD2A Histone Demethylase in Endometrial Carcinoma

Expression and Effects of JMJD2A Histone Demethylase in Endometrial Carcinoma

Risk factors for endometrial cancer: An umbrella review of the literature

Role of Metabolic Enzymes P450 (CYP) on Activating Procarcinogen and their Polymorphisms on the Risk of Cancers

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