Lack of association between the vitamin D receptor polymorphism rs2228570 and chronic periodontitis in a Han Chinese population

Abstract

ABSTRACT. The vitamin D receptor (VDR) is involved in the immune response and bone metabolism, both of which are implicated in the pathogenesis of chronic periodontitis (CP). In this study, we investigated the association between the VDR single nucleotide polymorphism rs2228570 and CP susceptibility in a Han Chinese population consisting of 440 moderate or severe CP patients and 324 controls. Genomic DNA was extracted from buccal epithelial cells and genotyped using matrix-assisted laser desorption/ ionization time-of-flight-mass spectrometry. No significant difference in allelic or genotypic frequencies distributions for rs2228570 was found between CP patients and controls. In conclusion, we found no statistically significant association between rs2228570 and CP in our population.

Polymorphisms of the vitamin D receptor gene (FOKI,CDX2, and GATA) and susceptibility to chronic periodontitis in diabetic and non‐diabetic individuals: A case‐control study

“…Although previous studies have reported an association between the Fok I (rs2228570) variant and the risk of CP development in other populations, no significant differences were found among the groups in the population studied herein, which is in agreement with other findings in the literature . Moreover, the Cdx2 (rs11568820) variant was also not significantly associated with DM2 and CP in this population, which is in agreement with the findings in previous studies on periodontal disease …”

“…the FokI (rs2228570) variant and the risk of CP development in other populations, 25,26 no significant differences were found among the groups in the population studied herein, which is in agreement with other findings in the literature. 24,[40][41][42] Moreover, the Cdx2 (rs11568820) variant was also not significantly associated with DM2…”

Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents

“…On the contrary, Li et al (2008) reported that F allele increased the susceptibility of aggressive periodontitis in Chinese (Li et al, 2008) and Park, Nam, and Choi (2006) reported that CC genotype associated with increased risk for generalized aggressive periodontitis in Koreans (Park et al, 2006). However, several studies have also reported no association between rs2228570 and periodontis (Wang, Zhang, & Chen, 2015; Wang et al, 2009; El Jilani et al, 2015; Tachi et al, 2003). …”

Vitamin D receptor FokI and BglI genetic polymorphisms, dental caries, and gingivitis

“…11 Some of these genetic polymorphisms were previously studied in the dental caries aetiology context; [12][13][14][15][16][17] however, the results are contradictory. Following a similar pattern, studies evaluating periodontal disease [18][19][20][21][22][23][24][25] investigated the association between many genetic polymorphisms in VDR in the aetiology of periodontal diseases, including gingivitis. 15 Dental caries and gingivitis are common non-communicable diseases in children.…”