Lack of association between the angiotensin-converting enzyme gene (I/D) polymorphism and diabetic nephropathy in Tunisian type 2 diabetic patients

Arfa, Imen; Abid, A.; Nouira, Saïd; Elloumi-Zghal, Houda; Malouche, Dhafer; Mannai, Imen; Zorgati, Mohamed Majdi; Alaya, Nissaf Ben; Rebai, Ahmed; Zouari, B.; Ammar, Slim Ben; Rayana, Mohamed Chiheb Ben; Hmida, Slama; Blousa-Chabchoub, S.; Abdelhak, Sonia

doi:10.3317/jraas.2008.002

Cited by 50 publications

(56 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, among Caucasians French, Turkish and Tunisian populations the ACE I/D polymorphism was not a marker for DN and renal prognosis of patients with T2DM (6,16,17,28). Also, among Iranians with Kurdish ethnic background ACE I/D polymorphism was not associated with the risk of microalbuminuria (10).…”

Section: Ace I/d Polymorphism: Onset and Progression Of Diabetic Nephmentioning

confidence: 75%

“…The frequency of ACE alleles varies in different ethnic groups and might contribute to the conflicting results related to the role of ACE (I/D) polymorphism in diabetic nephropathy (5,6).…”

Section: Angiotensin Converting Enzyme (Ace) Gene Polymorphismmentioning

confidence: 99%

“…The role of ACE I/D polymorphism in the pathogenesis of DN has been investigated in various ethnic groups with inconsistent results (6,11,17,18). Ethnicity is one of the most important factors, which determines the role of ACE gene polymorphism in the susceptibility to DN.…”

Section: Ace I/d Polymorphism: Onset and Progression Of Diabetic Nephmentioning

confidence: 99%

“…DN is manifested with microalbuminuria that subsequently can progress to macroalbuminuria (13,14). The ACE is a key component of renin angiotensin system (RAS) that plays an important role in blood pressure homeostasis by generating the vasoconstrictor peptide angiotensin II and by inactivating the vasodilator peptides bradykinin and angiotensin (1)(2)(3)(4)(5)(6)(7)15). ACE regulates microcirculation within the kidney through generating angiotensin II and in the presence of ACE D allele, the GFR increases in correlation with ACE plasma levels (1,16).…”

Section: Ace I/d Polymorphism: Onset and Progression Of Diabetic Nephmentioning

confidence: 99%

See 3 more Smart Citations

ACE insertion/deletion (I/D) polymorphism and diabetic nephropathy

Rahimi¹

2012

J Nephropathol

View full text Add to dashboard Cite

Implication for health policy/practice/research/medical education:The presence of angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism affects the plasma level of ACE. ACE DD genotype is associated with highest systemic and renal ACE levels, compared with the lowest ACE activity in carriers of II genotype. Most studies confirmed that ACE I/D polymorphism is involved in the susceptibility to overt nephropathy with protective role of ACE II genotype against the disease in both type 1 and 2 diabetes mellitus. In this review focus has been performed on the study of ACE I/D polymorphism in various populations and its influence on the risk of onset and progression of diabetic nephropathy. Results:The presence of ACE insertion/deletion (I/D) polymorphism affects the plasma level of ACE. ACE DD genotype is associated with the highest systemic and renal ACE levels compared with the lowest ACE activity in carriers of II genotype. Conclusions: In this review focus has been performed on the study of ACE I/D polymorphism in various populations and its influence on the risk of onset and progression of diabetic nephropathy. Also, association between ACE I/D polymorphism and response to ACE inhibitor and angiotensin II receptor antagonists will be reviewed. Further, synergistic effect of this polymorphism and variants of some genes on the risk of development of diabetic nephropathy will be discussed.Review Article

show abstract

Section: Ace I/d Polymorphism: Onset and Progression Of Diabetic Nephmentioning

confidence: 75%

“…The frequency of ACE alleles varies in different ethnic groups and might contribute to the conflicting results related to the role of ACE (I/D) polymorphism in diabetic nephropathy (5,6).…”

Section: Angiotensin Converting Enzyme (Ace) Gene Polymorphismmentioning

confidence: 99%

Section: Ace I/d Polymorphism: Onset and Progression Of Diabetic Nephmentioning

confidence: 99%

Section: Ace I/d Polymorphism: Onset and Progression Of Diabetic Nephmentioning

confidence: 99%

See 2 more Smart Citations

ACE insertion/deletion (I/D) polymorphism and diabetic nephropathy

Rahimi¹

2012

J Nephropathol

View full text Add to dashboard Cite

show abstract

“…In the same line, several studies in different population have reported that a strong relationship between the ACE DD genotype and the risk for diabetic nephropathy was reported in Malaysian [18], British Caucasian [19], Bahraini [20], Japanese [21], Korean [22], and Americans [14] populations. However, information from other studies in Chinese [23], German [24], Danish [25], Turkish [26], and Tunisian [27] populations were unsuccessful to prove this association. There were conflicting results in Iranian population regarding the association of ACE polymorphism; Nikzamir [28] demonstrated strong relation between the homozygous DD and nephropathy while Rahimi [29] showed no significant association.…”

Section: Discussionmentioning

confidence: 99%

The Combined Effect of ACE, TCF7L2, and PPARGC1A Gene Polymorphisms in Diabetic Nephropathy

et al. 2017

View full text Add to dashboard Cite

Keywords: Diabetic nephropathy (DN), Type 2 diabetes mellitus (T2DM), Angiotensinconverting enzyme (ACE), Transcription factor 7-like 2 (TCF7L2), Peroxisome proliferator activated receptor gamma coactivator-1 alpha (PPARGC1A). 62T HIS study was performed for investigation the relationship between variants of ACE, TCF7L2 and PPARGC1A gene polymorphisms individually or in combination with the development of nephropathy in T2DM.T he study was included 85 T2DM patients (45 with nephropathy and 40 without nephropathy), and 45 healthy control subjects. The I/D polymorphism of ACE gene was evaluated by PCR method. The polymorphisms rs7903146 (C/T) of TCF7L2 gene and Gly482Ser (G/A) and Thr394Thr (G/A) of PPARGC1A gene were evaluated by PCR-RFLP analysis.The frequency of ACE DD genotype and D allele was significantly higher in DN patients when compared to diabetic without nephropathy. The frequency of TCF7L2 rs7903146 TT genotype and T allele were significantly associated with DN patients compared to T2DM. Moreover, a significant association in A allelic frequencies was observed in DN cases compared to T2DM patients without nephropathy. No differences in the genotypic and allelic frequencies between T2DM patients with and without nephropathy were found for the Thr394Thr polymorphism.Our study suggested that candidate gene polymorphisms I/D of ACE, rs7903146 of TCF7L2 and Gly482Ser of PPARGC1A individually or in combination may act as susceptibility biomarkers for nephropathy in T2DM. IntroductionThe pathogenesis of diabetic nephropathy (DN) has many genetic and environmental factors contributing to its developing and progression. The ACE gene polymorphism is insertion/deletion (I/D) of a 287-bp sequence of DNA in the intron 16 that could be relating to circulating ACE level which involved in the etiology of DN [1,2].The transcription factor 7-like 2 (TCF7L2) is located on chromosome 10q25.3 which considered the main susceptibility gene for T2DM [3]. Wu [4] was reported that the TCF7L2 gene may be contributed to the etiology of DN in combination with other genes. However, Hussain [5] showed an association between TCF7L2 gene and DN, but this association is not independent of T2DM.Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) gene is located on chromosome 4p15.1 that is a biological and positional candidate for T2DM progression [6]. Furthermore, PPARGC1A Gly482Ser polymorphism is associated with diabetic nephropathy [7].There was no enough research available for the genetic combination of ACE, TCF7L2 and PPARGC1A gene polymorphisms in DN. Therefore the aim of this study was to assess the genetic interaction between ACE, TCF7L2 and PPARGC1A polymorphisms in DN development. Subjects and Methods Study subjectsThis study recruited 85 T2DM patients diagnosed at least 5 years before, the patients consecutively attended the diabetes clinic of Internal Medicine Department; Kasr El-Aini Hospital affiliated to Cairo University. Forty five of them (12 males and 33 females) with nephropathy, while ...

show abstract