Lack of association between TNF-α gene promoter polymorphisms and pancreatitis: A meta-analysis

Yang, Zhiping; Qi, Xingshun; Wu, Qiong; Li, Aijun; Xu, Ping; Fan, Daiming

doi:10.1016/j.gene.2012.04.057

Cited by 11 publications

(5 citation statements)

References 27 publications

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“…(13–15) Studies on the TNF-alpha promoter polymorphisms have been variable, with meta-analysis of −308G>A and −238G>A showing no association. (16–21) This is consistent with our own studies, however we also evaluated the −1031C and −863A alleles and found them to be associated with progression to multi-organ failure. (22)…”

Section: Initial Evaluation and Management Of Apsupporting

confidence: 91%

Genetics of acute and chronic pancreatitis

Mounzer

Whitcomb²

2013

Current Opinion in Gastroenterology

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Purpose of review Acute pancreatitis (AP), recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are interrelated and progressive inflammatory disorders of the pancreas with highly variable and complex susceptibility, severity and outcomes. The role of genetics in AP, RAP and progression to CP within a new framework is needed. Recent findings The first genome-wide association study in pancreas has been published with genome-wide significance linked with non-coding variants at the PRSS1-PRSS2 locus on chromosome 7 and the CLDN2 locus on the X chromosome. A new personalized medicine paradigm is considered to facilitate organization of genetic and other susceptibility risk compared to risk of disease progression or resolution and risk of complications. Summary A new framework for organizing multiple, complex data sets is emerging. The role of genetics in the context of other variables, is important in understanding susceptibility to RAP and in the modification of disease severity and progression to CP. Questions of when to order testing, what to order and how to use the data in real time remains an area for future research and development.

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Section: Initial Evaluation and Management Of Apsupporting

confidence: 91%

Genetics of acute and chronic pancreatitis

Mounzer

Whitcomb²

2013

Current Opinion in Gastroenterology

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“…TNF-α gene polymorphism was associated with severity but this finding has not been validated in other studies. [26][27][28] MCP-1 gene polymorphism was associated with increased risk of severe AP with the G allele acting as the risk factor but the data were inconsistent. 29,30 One study has shown genetic polymorphisms of IL-6 gene to alter the level of IL-6 but did not find any association with the severity of AP.…”

Section: How Common Is Of In Ap?mentioning

confidence: 99%

Organ Failure Due to Systemic Injury in Acute Pancreatitis

2019

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Acute pancreatitis may be associated with both local and systemic complications. Systemic injury manifests in the form of organ failure which is seen in approximately 20% of all cases of acute pancreatitis and defines 'severe acute pancreatitis'. Organ failure typically develops early in the course of acute pancreatitis, but may also develop later due to infected pancreatic necrosis induced sepsis. Organ failure is the most important determinant of outcome in acute pancreatitis. We review here the current understanding of the risk factors, pathophysiology, timing, impact on outcome and therapy of organ failure in acute pancreatitis. As we discuss the pathophysiology of severe systemic injury, the distinctions between markers and mediators of severity are highlighted based on evidence supporting their causality in organ failure. Emphasis is placed on clinically relevant end points of organ failure and the mechanisms underlying the pathophysiological perturbations, which offer insight into potential therapeutic targets to treat.

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“…The G-to-A transition at position -308 in the promoter region is associated with an elevated expression of TNF-a. Yet, previous meta-analyses did not find a significant association between the -308A/G polymorphism and acute pancreatitis risk (Yang et al, 2012;Yin et al, 2012). However, there is still controversy and uncertainty about the association between the TNF-a -308A/G polymorphism and the risk of CP.…”

Section: Introductionmentioning

confidence: 97%

The Association Between the Tumor Necrosis Factor-Alpha Gene −308A/G Polymorphism and Chronic Pancreatitis: A Meta-Analysis

Zhang

Pan

et al. 2020

Genetic Testing and Molecular Biomarkers

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Background: Tumor necrosis factor-alpha (TNF-a) is a major proinflammatory cytokine that has been posited to be involved in the development of chronic pancreatitis (CP). Several studies have been carried out that explored the association between the TNF-a-308A/G polymorphism and CP; however, conflicting results have emerged. The aim of this study was to perform a meta-analysis to provide a more precise assessment of the relationship between the TNF-a-308A/G polymorphism and CP risk. Methods: Case-control studies were identified using PubMed, Embase, Web of Science, Cochrane Library, and Chinese National Knowledge Infrastructure through January 2019 from which seven were identified that met all inclusion criteria. Results: This meta-analysis included 695 CP cases and 742 controls. A positive association was found between the A allele and the risk of CP using the additive model (OR [odds ratio] = 1.83, 95% CI [confidence interval] = 1.08-3.10). We also found, after excluding the Hardy-Weinberg equilibrium-violating studies, that the AA genotype was significantly associated with CP in both the additive and recessive models (OR = 2.28, 95% CI = 1.27-4.07; OR = 2.19, 95% CI = 1.26-3.81). Conclusion: This meta-analysis indicates that the A allele of the TNF-a-308A/G polymorphism increases the risk of CP.

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Lack of association between TNF-α gene promoter polymorphisms and pancreatitis: A meta-analysis

Cited by 11 publications

References 27 publications

Genetics of acute and chronic pancreatitis

Genetics of acute and chronic pancreatitis

Organ Failure Due to Systemic Injury in Acute Pancreatitis

The Association Between the Tumor Necrosis Factor-Alpha Gene −308A/G Polymorphism and Chronic Pancreatitis: A Meta-Analysis

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