Lack of association between transporter associated with antigen processing (TAP) and HLA‐DM gene polymorphisms and antibody levels following measles vaccination

Dhiman, Neelam; Ovsyannikova, Inna G.; Pinsky, Norman A.; Vierkant, Robert A.; Jacobsen, Steven J.; Jacobson, Robert M.

doi:10.1046/j.1365-2370.2003.00382.x

Cited by 6 publications

(3 citation statements)

References 47 publications

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“…In the present study, we found that the frequency of DMB*01:07 was lower in the seropositive group than that in the seronegative group; however, the difference was not significant after FDR correction. Dhiman et al 37 studied the antibody response to the measles vaccine and did not identify an association between DMA and DMB alleles. Immunopeptidome analysis indicates that HLA‐DM allotypes may affect antigen presentation and CD4+ T cell activation 2 .…”

Section: Discussionmentioning

confidence: 99%

Association of HLA‐DM and HLA class II genes with antibody response induced by inactivated Japanese encephalitis vaccine

Chen

Han

et al. 2022

HLA

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HLA class II molecules, HLA‐DR, DP and DQ, together with HLA II‐like protein DM, play a dominant role in the processing and presentation of antigens, which may influence vaccine effectiveness. We previously demonstrated that variations in the HLA‐DRB1, DPB1 and DQB1 genes may affect the neutralising antibody (NAb) response induced by the inactivated Japanese encephalitis vaccine (IJEV). In the present study, we genotyped HLA‐DPA1, DQA1, DMA and DMB genes and used previous HLA‐DRB1, DPB1 and DQB1 data to evaluate the association of these genes with IJEV‐induced NAbs, at both the seroconversion and geometric mean titres (GMTs). We confirmed the seropositive association of DQB1*02:01 and NAbs (0.156 vs. 0.075, p_adj = 0.018; OR = 2.270; 95% CI = 1.285–3.999) and seronegative association of DQB1*02:02 (0.014 vs. 0.09, p_adj = 0.0002; OR = 0.130; 95% CI = 0.047–0.400). Furthermore, the DMB*01:03–DMA*01:01–DPA1*01:03–DPB1*04:01 haplotype was associated with a negative response (0.020 vs. 0.074; p_adj = 0.03; OR = 0.250; 95% CI = 0.097–0.649), whereas DRB1*15:02–DMB*01:01–DMA*01:01 was associated with a positive response (0.034 vs. 0; p_adj = 0.044). In addition, DRB1*12:02, DRB1*13:02, DPB1*04:01, DPB1*05:01, DPB1*09:01, DQA1*06:01 and DQA1*01:02 were associated with a higher GMT of NAbs, whereas DRB1*11:01, DPB1*13:01 and DQA1*05:05 were associated with a lower GMT of NAbs. In conclusion, the present study suggests that variations in the HLA‐DM and HLA class II genes, as well as their combined allotypes, may influence the IJEV NAbs at seroconversion and GMT levels.

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Section: Discussionmentioning

confidence: 99%

Association of HLA‐DM and HLA class II genes with antibody response induced by inactivated Japanese encephalitis vaccine

Chen

Han

et al. 2022

HLA

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“…Several DM polymorphisms have been associated with predisposition to diseases such as Rheumatoid Arthritis (RA), Juvenile RA, medicamentosa-like Dermatitis, Primary Antiphospholipid Syndrome, Psoriasis and atopic Dermatitis (Toussirot et al, 2000;West and Reed, 1999;Yue et al, 2007;Sanchez et al, 2004;Pyo et al, 2003;Kuwata et al, 1996). Additionally, DM polymorphisms may influence vaccine responses (Dhiman et al, 2003;Ovsyannikova et al, 2004). However, no molecular mechanism behind these effects has been established yet and it is not known whether these polymorphisms alter the editing properties of DM.…”

Section: Naturally Occurring Polymorphisms In Immunopeptidome Editorsmentioning

confidence: 99%

Cellular Mechanisms that Edit the Immunopeptidome

Georgiadou¹,

Stratikos

2009

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The adaptive immune response relies on the ability of T-lymphocytes to recognize small antigenic peptides presented on the cell surface by specialized receptors of the Major Histocompatibility Complex (MHC). These peptides are either generated by the degradation of intracellular proteins (MHC class I pathway) or by the degradation of internalized extracellular proteins (MHC class II pathway and cross-presentation pathway). The number of proteins that can be degraded by these pathways runs to the thousands leading to a staggering number of possible peptide fragments. A small subset of these peptides is selected by the cell's processing and presentation mechanisms to be presented on the cell surface by MHC molecules and has been defined as the immunopeptidome. The peptide sequences that comprise the immunopeptidome control the immune response and variations of this peptide repertoire are key to understanding the host's ability to fight pathogens, immune response to cancer as well as predisposition to autoimmunity and allergies. In the last few years it has been established that the composition of the immunopeptidome is regulated by specific cellular mechanisms that influence qualitative and quantitative aspects of the cellular immune response in a process that has been described as antigenic peptide editing. This review explores the current knowledge on these cellular mechanisms and discusses the parallels between editing the MHC class I and class II immunopeptidomes.

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“…immune disorders [33][34][35][36] or not at all [37][38][39][40]. Assigning a role for TAP polymorphism in disease susceptibility will require carefully powered studies with stratification of the data to control for linkage disequilibrium with other genes in the MHC class II region.…”

Section: Human Tap Polymorphism and Diseasementioning

confidence: 99%