Lack of Association Between Tumor Hypoxia, Glut-1 Expression and Glucose Uptake in Experimental Sarcomas

Thews, Oliver; Kelleher, Debra K.; Esser, N.; Kraus, Stephan; Vaupel, Peter

doi:10.1007/978-1-4615-0205-0_10

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Cited by 6 publications

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“…0.1% O 2 is about the oxygen concentration where aerobic glucolysis yields to ATP production by anaerobic glucolysis (2, 10). The low-energy output by anaerobic glucolysis is in normal tissue and during short periods of severe hypoxia partly countered by increased glucose uptake by the cells, but not necessarily so in tumour tissue (17).…”

mentioning

confidence: 99%

Linking measured intercellular oxygen concentration to human cell functions

Ebbesen¹,

Eckardt²,

Cĭampor³

et al. 2004

Acta Oncologica

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mentioning

confidence: 99%

Linking measured intercellular oxygen concentration to human cell functions

Ebbesen¹,

Eckardt²,

Cĭampor³

et al. 2004

Acta Oncologica

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Microenvironmental Effects on Tumour Progression and Metastasis

Måseide

Kalliomäki

Hill

Cancer Growth and Progression

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Abstract:The microenvironment of a tumour differs significantly from that of a normal tissue due to abnormal vasculature and altered cellular metabolism in tumours. Microenvironmental conditions in tumours, which include hypoxia, acidity, nutrient deprivation and high interstitial fluid pressure, have been associated with metastatic tumour progression both experimentally and clinically. The mechanisms by which this occurs are believed to include genomic instability, changes in gene expression levels and microenvironment-mediated selective pressure. These genomic changes modify cell survival and growth during the angiogenic, migratory and invasive stages of tumour progression and metastasis. This chapter summarises the data examining links between tumour microenvironment and metastasis and discusses the possibility of using microenvironmentally regulated genes as intrinsic prognostic markers.

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