Lack of association between vitamin D receptor gene FokI and BsmI polymorphisms and prostate cancer risk: an updated meta-analysis involving 21,756 subjects

Guo, Zhan; Wen, Jianguo; Kan, Quancheng; Huang, Shuman; Li, Xianghua; Sun, Ning; Li, Zhenzhen

doi:10.1007/s13277-013-0889-6

Cited by 22 publications

(23 citation statements)

References 37 publications

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“…A recent meta-analysis, including thirty-four studies for a total of 10,267 cases and 11,489 controls, focused on the association between vitamin D receptor (VDR) polymorphisms, which mediate the cellular effects of vitamin D and risk of prostate cancer. No evidence to support an association between any of the VDR polymorphisms and risk of prostate cancer was found [83]. Further studies have found there to be no convincing association and random control trials are lacking.…”

Section: Resultsmentioning

confidence: 99%

Prostate cancer and the influence of dietary factors and supplements: a systematic review

et al. 2014

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BackgroundProstate cancer is the second most common cause of cancer worldwide after lung cancer. There is increasing evidence that diet and lifestyle plays a crucial role in prostate cancer biology and tumourigenesis. Prostate cancer itself represents a good model of cancer in which to look for chemopreventive agents due to the high disease prevalence, slowly progressive nature, and long latency period. Dietary agents have gained considerable attention, often receiving much publicity in the media.AimTo review the key evidence available for potential chemopreventive nutrients.MethodsThe methodology for this review involved a PubMed search from 1990 to 2013 using the key-words “diet and prostate cancer”, “nutrition and prostate cancer”, “dietary factors and prostate cancer”, “prostate cancer epidemiology”, “prostate cancer prevention”, “prostate cancer progression”.ResultsRed meat, dietary fat and milk intake should be minimised as they appear to increase the risk of prostate cancer. Fruit and vegetables and polyphenols may be preventive in prostate cancer, but further studies are needed to draw more solid conclusions and to clarify their role in patients with an established diagnosis of prostate cancer. Selenium and vitamin supplements cannot be advocated for the prevention of prostate cancer and indeed higher doses may be associated with a worse prognosis. There is no specific evidence regarding benefits of probiotics or prebiotics in prostate cancer.ConclusionsFrom the wealth of evidence available, many recommendations can be made although more randomised control trials are required. These need to be carefully designed due to the many confounding factors and heterogeneity of the population.

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Section: Resultsmentioning

confidence: 99%

Prostate cancer and the influence of dietary factors and supplements: a systematic review

et al. 2014

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“…) and cancer risk with inconclusive results (179,238,270,516) (227). Recently, Narvaez et al (323) reported that in The Cancer Genome Atlas datasets Ͻ2% of breast cancers exhibit genomic alterations (including amplifications, deletions, mutations, and changes in mRNA) (323).…”

Section: Vdr Expression and Vitamin D Metabolism In Cancer Cellsmentioning

confidence: 99%

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects

Christakos

Dhawan

Verstuyf

et al. 2016

Physiological Reviews

1,473

1,234

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, [1,25(OH) 2 D 3 ] is the hormonally active form of vitamin D. The genomic mechanism of 1,25(OH) 2 D 3 action involves the direct binding of the 1,25(OH) 2 D 3 activated vitamin D receptor/retinoic X receptor (VDR/RXR) heterodimeric complex to specific DNA sequences. Numerous VDR co-regulatory proteins have been identified, and genome-wide studies have shown that the actions of 1,25(OH) 2 D 3 involve regulation of gene activity at a range of locations many kilobases from the transcription start site. The structure of the liganded VDR/RXR complex was recently characterized using cryoelectron microscopy, X-ray scattering, and hydrogen deuterium exchange. These recent technological advances will result in a more complete understanding of VDR coactivator interactions, thus facilitating cell and gene specific clinical applications. Although the identification of mechanisms mediating VDR-regulated transcription has been one focus of recent research in the field, other topics of fundamental importance include the identification and functional significance of proteins involved in the metabolism of vitamin D. CYP2R1 has been identified as the most important 25-hydroxylase, and a critical role for CYP24A1 in humans was noted in studies showing that inactivating mutations in CYP24A1 are a probable cause of idiopathic infantile hypercalcemia. In addition, studies using knockout and transgenic mice have provided new insight on the physiological role of vitamin D in classical target tissues as well as evidence of extraskeletal effects of 1,25(OH) 2 D 3 including inhibition of cancer progression, effects on the cardiovascular system, and immunomodulatory effects in certain autoimmune diseases. Some of the mechanistic findings in mouse models have also been observed in humans. The identification of similar pathways in humans could lead to the development of new therapies to prevent and treat disease.

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“…However, the results across studies have been equivocal [34, 35, 36]. Previous meta-analyses were performed by Xu et al in 2014, Guo et al in 2013 and Yin et al in 2009 [34, 37, 44]. Xu et al and Yin et al reported the relationship of cancer risk with several VDR SNPs including Fok I .…”

Section: Discussionmentioning

confidence: 99%

Association of vitamin D receptorFok Ipolymorphism with the risk of prostate cancer: a meta-analysis

et al. 2016

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Several previous studies have been reported to examine the association between Vitamin D receptor (VDR) gene Fok I polymorphism and susceptibility to prostate cancer (PCa), however the results remain inconclusive. To provide a relatively comprehensive account of the association, we searched PubMed, Embase, CNKI, and Wanfang for eligible studies and carry out this meta-analysis. A total of 27 case-control studies with 10,486 cases and 10,400 controls were included. In the overall analysis, Fok I polymorphism was not significantly associated with the susceptibility to PCa. Subgroup analyses showed that significantly association was existed in Caucasian population, the subgroup of population-based controls and the stratified group with advanced tumor.These results indicate that the VDR Fok I polymorphism might be capable of causing PCa susceptibility and could be a promising target to forecast the PCa risk for clinical practice. However further well-designed epidemiologic studies are needed to confirm this conclusion.

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Lack of association between vitamin D receptor gene FokI and BsmI polymorphisms and prostate cancer risk: an updated meta-analysis involving 21,756 subjects

Cited by 22 publications

References 37 publications

Prostate cancer and the influence of dietary factors and supplements: a systematic review

Prostate cancer and the influence of dietary factors and supplements: a systematic review

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects

Association of vitamin D receptorFok Ipolymorphism with the risk of prostate cancer: a meta-analysis

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