2007
DOI: 10.1093/jnci/djm233
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Lack of Association of Alcohol and Tobacco with HPV16-Associated Head and Neck Cancer

Abstract: Alcohol or tobacco use does not further increase risk of HPV16-associated pharyngeal cancer. HNSCC risk associated with smoking, alcohol, and HPV16 differs by tumor site.

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Cited by 231 publications
(265 citation statements)
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“…This result is consistent with other studies (Applebaum et al, 2007). For alcohol drinking, as in many previous studies (Chung et al, 2005;Corrao et al, 2004) we found alcohol drinking was significantly associated with oral cancer.…”
Section: Discussionsupporting
confidence: 94%
“…This result is consistent with other studies (Applebaum et al, 2007). For alcohol drinking, as in many previous studies (Chung et al, 2005;Corrao et al, 2004) we found alcohol drinking was significantly associated with oral cancer.…”
Section: Discussionsupporting
confidence: 94%
“…It has been shown that smoking increases the risk of OPC, irrespective of HPV16 status,55 but evidence of an effect of joint exposure on survival after diagnosis is conflicting. Some studies report reduced survival in HPV‐positive smokers compared to their non‐smoking counterparts,18 whilst others report no difference in prognosis between HPV‐positive smokers and HPV‐positive non‐smokers 56. To the best of our knowledge, no studies have compared the prognostic value of alcohol use in people with HPV‐positive versus HPV‐negative OPCs.…”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, many studies have suggested that tobacco use and alcohol consumption increase the risk of head and neck cancer (Coelho, 2012;Zhou et al, 2012). Whether HPV is an independent risk factor of tobacco and alcohol, the other two major causes of tumors at these sites, has not been well clarified (Herrero, et al, 2003;Applebaum et al, 2007;Gillison et al, 2008;Smith et al, 2010a). It is known that those who are infected with HPV have significantly better survival (Klussmann et al, 2003;Smith et al, 2010b), thus it would be important to clarify the role of these risk factors.…”
Section: Discussionmentioning
confidence: 99%