Lack of association of angiotensin I‐converting enzyme gene polymorphism and premature myocardial infarction in Mauritian Indians

Ramasawmy, Rajendranath; Manraj, Meera; Kotea, Navaratnam; Shun, Nathalie Kok; Génin, Emmanuelle; Feingold, Josué; Krishnamoorthy, Rajagopal; Baligadoo, Sooriahnarain

doi:10.1111/j.1399-0004.1996.tb02737.x

Clinical Genetics

1996

DOI: 10.1111/j.1399-0004.1996.tb02737.x

|View full text |Cite

Lack of association of angiotensin I‐converting enzyme gene polymorphism and premature myocardial infarction in Mauritian Indians

Rajendranath Ramasawmy

Meera Manraj²,

Navaratnam Kotea³

et al.

Abstract: Eighty‐five young Mauritian Indians, male survivors of premature myocardial infarction (MI) and thus belonging to a high risk group, were compared with 108 stringently selected controls for a possible association between premature MI and an insertion/deletion (I/D) polymorphism in the gene encoding angiotensin I‐converting enzyme (ACE). The frequency of the D allele was 0.42 in the MI group and 0.43 in the control group, and thus no association between I/D polymorphism of ACE with susceptibility to early‐onset… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1998

2017

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 8 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17,52,54,[57][58][59][60][62][63][64]68,73,74,76,77,79,80,82,84,86,88,[90][91][92][93]96,97,99,100,104,106,107,110,[112][113][114]116,119,124,125,128,132,134,135,139,144,147,148,150,156,158,160, 162 CAD documented by angiography 49 56-59, 64, 67, 73, 75, 77-80, 82-84, 87-89, 90-94, 98, 100, 101, ...…”

mentioning

confidence: 99%

Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphic Variant as a Marker of Coronary Artery Disease<subtitle>A Meta-analysis</subtitle>

Ζιντζαράς¹

2008

Arch Intern Med

114

View full text Add to dashboard Cite

Background: Many studies have investigated the association between the angiotensin-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphic variant and coronary artery disease (CAD). However, the evidence is inadequate to draw robust conclusions because most studies were generally small and conducted in heterogeneous samples. To shed light on these inconclusive findings, we conducted a meta-analysis of studies relating the ACE I/D polymorphic variant to the risk of CAD.Methods: We searched the PubMed database for Englishlanguage articles on CAD in humans. We estimated summary odds ratios and explored potential sources of heterogeneity and bias. Results:The 118 studies chosen for the analysis involved 43 733 cases with CAD and 82 606 controls. The heterogeneity between studies was significant. When we compared homozygotes with the D and I alterations, the ACE I/D polymorphic variant was associated with a 25% increased risk of CAD (odds ratio, 1.25; 95% confidence interval, 1.16-1.35). Subgroup analyses for myocardial infarction, diabetes mellitus, male sex, white race, East Asian subjects, and Turkish subjects showed significant associations. No association was found in other racial/ethnic groups, in women, in premature cases, or in cases with low levels of risk factors. The major sources of heterogeneity were due to racial/ethnic diversity, genotyping procedure, and age matching. Cumulative meta-analysis for the allelic contrast showed a trend of association as information accumulated. There was a differential magnitude of effect in large vs small studies. Conclusions:The meta-analysis demonstrated evidence of a modest positive association between ACE I/D polymorphic variant and CAD. The meta-analysis also highlights the heterogeneity of reported results, considerable gaps in research, and the need for future studies focused on certain high-risk patient populations.

show abstract

mentioning

confidence: 99%

Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphic Variant as a Marker of Coronary Artery Disease<subtitle>A Meta-analysis</subtitle>

Ζιντζαράς¹

2008

Arch Intern Med

114

View full text Add to dashboard Cite

show abstract

Gene–Gene Interaction in the RAS System in the Predisposition to Myocardial Infarction in Elder Population of St. Petersburg (Russia)

Fomicheva

Gukova

Larionova-Vasina

et al. 2000

Molecular Genetics and Metabolism

View full text Add to dashboard Cite

Vascular injury in systemic sclerosis: Angiotensin-converting enzyme insertion/deletion polymorphism

et al. 2004

View full text Add to dashboard Cite

The microvascular involvement in systemic sclerosis (SSc) is characterized by endothelial damage and smooth muscle cell migration in the intima. The vascular pathologic modifications in SSc are strikingly similar to those of atherosclerosis. SSc also is characterized by an accelerated macrovascular disease. The gene encoding for angiotensin-converting enzyme (ACE) is a 21-kb, 26-exon gene, localized on chromosome 17 (17q23). Polymorphic sites are an insertion/deletion (I/D) that consists of three genotypes: DD and II homozygotes, and ID heterozygote. ACE gene polymorphisms have been linked to vascular disorders (coronary artery disease, hypertension, cerebrovascular disease, hypertrophic cardiomyopathy, and diabetic or nondiabetic nephropathy). In particular, the possession of ACE D allele was associated with an increased risk of developing malignant vascular injury. ACE D allele frequency of the I/D polymorphism was associated with an increased risk of SSc, suggesting a genetic contribution to the disease. The discrepancy between the high prevalence of D allele and reduced ACE plasma levels in SSc demonstrate the lack of knowledge on the regulation and function of renin-angiotensin system in SSc.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Lack of association of angiotensin I‐converting enzyme gene polymorphism and premature myocardial infarction in Mauritian Indians

Cited by 8 publications

References 22 publications

Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphic Variant as a Marker of Coronary Artery Disease<subtitle>A Meta-analysis</subtitle>

Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphic Variant as a Marker of Coronary Artery Disease<subtitle>A Meta-analysis</subtitle>

Gene–Gene Interaction in the RAS System in the Predisposition to Myocardial Infarction in Elder Population of St. Petersburg (Russia)

Vascular injury in systemic sclerosis: Angiotensin-converting enzyme insertion/deletion polymorphism

Contact Info

Product

Resources

About