Lack of Association of Common Polymorphisms in MUC1 Gene with H. pylori Infection and Non-cardia Gastric Cancer Risk in a Chinese Population

Zhang, Bin; Hao, Guangyu; Gao, Fang; Zhang, Jian-zu; Zhou, Chengjiang; Zhou, Li-She; Wang, Ying; Jia, Yongsheng

doi:10.7314/apjcp.2013.14.12.7355

Cited by 15 publications

(15 citation statements)

References 17 publications

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“…Studies conducted in Bhutan (Dorji et al, 20013) and China (Zhang et al, 2013) documented identical prevalence with no statistically significance different among age groupd. However, Alizadeh et al (2009) found out that the prevalence of H. pylori increased with age.…”

Section: Discussionmentioning

confidence: 87%

Prevalence and Risk Factors of H. pylori from Dyspeptic Patients in Northwest Ethiopia: A Hospital Based Cross-sectional Study

Abebaw¹,

Kibret²,

Abera³

2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 87%

Prevalence and Risk Factors of H. pylori from Dyspeptic Patients in Northwest Ethiopia: A Hospital Based Cross-sectional Study

Abebaw¹,

Kibret²,

Abera³

2014

Asian Pacific Journal of Cancer Prevention

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“…Age and gender distributions were comparable between the two groups. The demographic of subjects are shown in Table 1 (Zhang et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

“…Details of the study subjects have been described elsewhere (Zhang et al, 2013). Briefly, all patients with histopathologically confirmed incident non-cardia gastric cancer were consecutively recruited between June 2008 and December 2010 at the cancer hospital of Baotou.…”

Section: Subjectsmentioning

confidence: 99%

Association Analysis of Common Genetic Variations in MUC5AC Gene with the Risk of Non-cardia Gastric Cancer in a Chinese Population

Zhou¹,

Zhang²,

Gao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Several lines of evidence suggest that genetic variation in MUC5AC gene might contribute to the risk of gastric cancer. We conducted a case-control study to evaluate the relationship between common genetic variations in MUC5AC gene and non-cardia gastric cancer using an LD-based tagSNP approach in Baotou, north-western China. We genotyped 12 tagSNPs by TaqMan method among 288 cases with non-cardia gastric cancer and 281 normal controls. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for non-cardia gastric cancer risk in association with alleles, genotypes and haplotypes. We observed that the frequencies of rs3793964 C allele and rs11040869 A allele were significantly lower in cases than in controls. Meanwhile, minor allele homozygotes of rs3793964 and rs11040869 were significantly associated with a decreased risk of non-cardia gastric cancer when compared with their major allele homozygotes. Furthermore, a statistically significantly protective effect of rs885454 genotypes on non-cardia gastric cancer was also observed (for CT vs. CC: OR=0.581, 95%CI=0.408-0.829; for CT/TT vs. CC: OR=0.623, 95%CI=0.451-0.884). Our results indicated that some common genetic variations in the MUC5AC gene might have effects on the risk of non-cardia gastric cancer in our studied population.

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“…Again this study recorded higher prevalence of H.pylori in black compared to the white patient. There are conflicting reports on the relationship between age of patients and prevalence of H. pylori, Studies conducted in Bhutan [26] and China [27], documented similar prevalence rate but with no statistically significant difference between H.pylori infection and age group. However, [28] found out that the prevalence of H. pylori increased with age.…”

Section: Discussionmentioning

confidence: 98%

The Prevalence of Helicobacter Pylori Infection among Outpatients Attending Hospitals in Johannesburg South Africa

Chinaka¹

2018

Microbiol Infect Dis

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Background: H. pylori is commonly incriminated in most cases of epigastric discomfort and stomach cancer. Aim: The study determined the prevalence of H. pylori infection among patients visiting out patient's clinic. Methodology: Two hundred patients with age range 10-50 years attending clinics were recruited for the study and screened for H. Pylori infection. Ethical approval was obtained from the Ethics Committee of 4 different hospitals in Johannesburg as well as informed consent of the participants. Blood and Stool samples and breath from the Nostril were used for the investigation. Serological, Cultural and Urea Breath Test were methods used for assessment of the Blood, Stool and Expels respectively. Values obtained were statistically analyzed. Results: Seventy four (37%) patients tested positive to H. Pylori. Males had 47% positive cases while female were 53%. 66% of the black race tested positive while the white were 34%. Alcohol and Cigarette Consumers who tested positive were 29 (39%) and 26(35%) respectively. Hand washing after visiting toilet is 10(14%) and hand washing before meal is 9 (12%). Conclusion: The findings of this study showed that age, sex, race and some food substances consuming may predispose to H. prlori infection.

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Lack of Association of Common Polymorphisms in MUC1 Gene with H. pylori Infection and Non-cardia Gastric Cancer Risk in a Chinese Population

Cited by 15 publications

References 17 publications

Prevalence and Risk Factors of H. pylori from Dyspeptic Patients in Northwest Ethiopia: A Hospital Based Cross-sectional Study

Prevalence and Risk Factors of H. pylori from Dyspeptic Patients in Northwest Ethiopia: A Hospital Based Cross-sectional Study

Association Analysis of Common Genetic Variations in MUC5AC Gene with the Risk of Non-cardia Gastric Cancer in a Chinese Population

The Prevalence of Helicobacter Pylori Infection among Outpatients Attending Hospitals in Johannesburg South Africa

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