Lack of association of common variants on chromosome 2p with primary open-angle glaucoma in the Japanese population

The relationship of TP53 and GRIN2B gene polymorphisms with risk of occurrence and progression of primary open-angle glaucoma in a Polish population

“…This result is confirmed by studies conducted in Indian, Turkish and Japanese populations [27,28,45], but some studies indicate a relationship of this polymorphism with the development of POAG [25,26]. Lin et al [26] demonstrated that the proline form of TP53 gene codon 72 appears to be a significant risk factor in the development of POAG (OR = 2.39 [95% CI: 1.14-5.01, p = 0.008]).…”

“…Previous studies have reported that the TP53 codon 72 polymorphism is associated with POAG [24][25][26], but other research has not confirmed these results [27,28]. These inconsistent data necessitate more studies with a larger number of cases and different ethnic populations to fully elucidate the relationship between TP53 and POAG.…”

Involvement of Genetic Variants Associated With Primary Open-Angle Glaucoma in Pathogenic Mechanisms and Family History of Glaucoma

“…However, no significant associations between these genetic variants and POAG (NTG and HTG) have been observed in the Japanese population. 35 Furthermore, the IOP-related genetic variants near the TMCO1 gene identified in the white population 18,23 are not polymorphic in the Japanese population. However, the size of our cohorts was almost 200 for the case and control subjects, and the delineation of the NTG or HTG was only based on a Goldmann applanation tonometer reading below or above 21 mm Hg.…”

Association of TP53 Polymorphisms with Primary Open-Angle Glaucoma: A Meta-Analysis

“…[37][38][39][40][41][42][43][44][45] The flow chart of literature search is shown in Figure 1. Nine studies [37][38][39][40][41][42][43][44][45] were included in the meta-analysis of p53 codon 72 genotype (1930 cases, 1463 controls), of which, in two studies, 43,44 the distribution of the genotypes in the control group were not in HWE (Fisher's exact test, P < 0.05). Four case-control studies [38][39][40]42 were included in the meta-analysis of intron 3 16-bp insertion genotype (858 cases, 683 controls).…”

“…However, the association between such polymorphisms in p53 and POAG remains controversial according to previous reports. [38][39][40][41][42][43][44] To date, no meta-analysis has been conducted to elevate the association of the polymorphisms of TP53 with POAG. Thus, it stimulated us to conduct a meta-analysis based on a total of nine independent studies, which may provide the evidence for the association of p53 polymorphisms with POAG susceptibility.…”