Lack of association of ACP1 gene with inflammatory bowel disease: a case–control study

Abstract

The red cell acid phosphatease (ACP1) gene, which encodes a low molecular weight phosphotyrosine phosphatase (LMW-PTP), has been suggested as a common genetic factor of autoimmunity. In the present study, we aimed to investigate the possible influence of ACP1 polymorphisms in the susceptibility of inflammatory bowel disease (IBD). A total of 1271 IBD Spanish patients [720 Crohn's disease (CD) and 551 ulcerative colitis (UC)] and 1877 healthy subjects were included. Four single-nucleotide polymorphisms (SNPs), rs10167992, rs11553742, rs7576247 and rs3828329, were genotyped using TaqMan SNP genotyping assays. Common ACP1 alleles (i.e. ACP1*A, ACP1*B and ACP1*C) were determined by two of these SNPs. After the analysis, no evidence of association of the ACP1 genetic variants was found with CD or UC. Therefore, our results suggest that the ACP1 gene may not play a relevant role in the development of IBD.

Quality of life in patients with ulcerative colitis with surgical intervention comparing tomedical treatment in King Abdulaziz University hospital in Saudi Arabia, Jeddah

“…Portugal and Galicia, in Portugal most UC patients were women (57%) which proves our result (Barreiro-de Acosta et al, 2010). In another study that supported our study; they stated that women are more prone to get affected by UC than men (Teruel et al, 2012).…”