Lack of Association of Intron 3 16 bp Polymorphism of TP53 with Breast Cancer among Iranian-Azeri Patients

Pouladi, Nasser; Kouhsari, Shideh Montasser; Feizi, Mohammad Ali Hosseinpour; Dehghan, Roghayeh; Azarfam, Parvin; Farajzadeh, Davoud

doi:10.7314/apjcp.2014.15.6.2631

Cited by 11 publications

(5 citation statements)

References 27 publications

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“…In the present study PIN3 Ins16bp polymorphism was not found to be associated with the risk of developing breast cancer. Similar to our results, no association of PIN3 Ins16bp polymorphism Sarika Sharma et al with risk of breast cancer was observed in Turkish (Akkiprik et al, 2009), Arabian (Alawadi et al, 2011) and Iranian (Pouladi et al, 2014) patients. In the present study higher frequency of A2A2 genotype was observed in the patients (7%) as compared to the controls (4%) but the results were not statistically significant.…”

Section: Discussionsupporting

confidence: 90%

TP53 Polymorphisms in Sporadic North Indian Breast Cancer Patients

Sharma¹,

Sambyal²,

Guleria³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 90%

TP53 Polymorphisms in Sporadic North Indian Breast Cancer Patients

Sharma¹,

Sambyal²,

Guleria³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…In this study, an increased frequency of the A2 allele (21.7%) was observed in Malian population, suggesting that PIN3 16-bp polymorphism duplication of the TP53 gene is an important genetic marker for cancer in Malian population. This frequency was close to those observed in Morocco (19.3%) [20], Tunisia (22%) [36], Turkey (23%) [19] but different from those obtained in Germany (16%) [17], Portugal (16%) [18], India (19%) [23], the United States (14%) [23], Iran (55.2%) [41] and among an Arabic population (30.8%) [28]. This disparity in the distribution of allelic frequency in the general population may also be due to the sample size, ethnic origin and geographic location.…”

Section: Discussionsupporting

confidence: 89%

Association of PIN3 16-bp Duplication Polymorphism of TP53 gene with Breast Cancer Risk in Mali and A Meta-analysis.

Diakité

Kassogue

Dolo

et al. 2020

Preprint

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Abstract Background. Breast cancer, the most common tumor in women in Mali and worldwide has been linked to several risk factors, including genetic factors, such as the PIN3 16-bp duplication polymorphism of TP53 gene. The aim of our study was to evaluate the role of the PIN3 16-bp duplication polymorphism in the susceptibility to breast cancer in the Malian population and to perform a meta-analysis to better understand the correlation with data from other populations.Methods. We analyzed the PIN3 16-bp duplication polymorphism in blood samples of 60 Malian women with breast cancer and 60 healthy appearing Malian women using PCR. In addition, we performed a meta-analysis of data from case-control studies published in articles retrieved from international databases (Pubmed, Harvard University Library, Genetics Medical Literature Database, Genesis Library and Web of Science). Overall, odds ratio (OR) with 95% CI from fixed and random effects models were determined. Inconsistency was used to assess heterogeneity between studies and publication bias was estimated using the funnel plot.Results. In the studied Malian patients, a significant association of PIN3 16-bp duplication polymorphism with breast cancer risk was observed in dominant (A1A2+A2A2 vs. A1A1: OR = 2.26, CI 95% = 1.08-4.73; P = 0.02) and additive (A2 vs. A1: OR =1.87, CI 95% = 1.05-3.33; P = 0.03) models, but not the recessive model (P = 0.38). In the meta-analysis, nineteen (19) articles were included with a total of 6,018 disease cases and 4,456 controls. Except for the dominant model (P = 0.15), an increased risk of breast cancer was detected with the recessive (OR=1.46, 95% CI = 1.15-1.85; P = 0.002) and additive (OR = 1.11, 95% CI = 1.02-1.19; P = 0.01) models.Conclusion. The Malian case-control study suggests that PIN3 16-bp polymorphism duplication of TP53 gene is an important risk factor for breast cancer in Malian women. These findings are supported by the meta-analysis of studies from different ethnicities.

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“…During past decades, numbers of genetic polymorphism in p53 locus have been widely investigated fo their effect in different cancer risks (Liu et al, 2014;Rao et al, 2014;Pouladi et al, 2014), among them the most common polymorphism is at codon 72 (Arg72Pro) (G>C) (rs1042522) This codon which is found at exon 4 of the p53 gene and is frequently studied worldwide (Vijayaraman et al, 2012;Xiang et al, 2012;Kafshdooz et al, 2014). At codon 72, arginine to proline substitution altered the p53 gene translation product, resulted in a reduced capacity of DNA repair, cell cycle regulation, apoptosis and thereby increased the susceptibility of cancer risk (Grochola et al, 2010).…”

Section: No Evidence Of Association Of the Arg72pro P53 Genementioning

confidence: 99%

No Evidence of Association of the Arg72Pro p53 Gene Polymorphism with Cancer Risk in the Saudi Population: a Meta-Analysis

Irshad

Mandal²,

AlDrees³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Earlier studies on the association between p53 codon 72 Arg>Pro polymorphism and cancer risk were inconclusive and conflicting for the Saudi population. Therefore, we performed a meta-analysis to investigate the relationship between the codon 72 Arg>Pro polymorphism and overall cancer risk in Saudi Arabia. Materials and Methods: We searched all eligible published studies and data were pooled together to perform the meta-analysis. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for homozygous, heterozygous, dominant and recessive genetic models. Results: A total of five eligible published studies covering 502 cancer cases and 784 healthy controls were included in the meta-analysis. No publication bias was detected in this study. The results suggested that the variant (Pro vs Arg: p=0.960; OR=1.004, 95% CI=0.852-1.183), homozygous (Pro.

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Lack of Association of Intron 3 16 bp Polymorphism of TP53 with Breast Cancer among Iranian-Azeri Patients

Cited by 11 publications

References 27 publications

TP53 Polymorphisms in Sporadic North Indian Breast Cancer Patients

TP53 Polymorphisms in Sporadic North Indian Breast Cancer Patients

Association of PIN3 16-bp Duplication Polymorphism of TP53 gene with Breast Cancer Risk in Mali and A Meta-analysis.

No Evidence of Association of the Arg72Pro p53 Gene Polymorphism with Cancer Risk in the Saudi Population: a Meta-Analysis

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